Neuromuscular blocking agents: alkyl and heterocyclic analogues of simple linear trisonium compounds

Abstract

A further series of linear hexamethylene‐NNN‐trisonium compounds has been synthesised and tested for neuromuscular blocking activity. In the alkyl‐substituted derivatives, at least one Et is required for significant potency in mammals. Apart from the Et2Bun and EtBu2n compounds, larger alkyl substituents lower potency. High potency in mammals requires at least two Et groups on the terminal nitrogens, if the third group is not Me. Only weak activity was shown by the morpholino‐deriatives but the fowl was highly sensitive towards the piperidino‐ and tetrahydro‐papaverino‐compounds. The results are discussed.