Neuromuscular Blocking Action of some Antibiotics

The Electromyographic Changes Induced by Antibiotics

“…However, it was shown that tetracycline as well as streptomycin increase the curarizing ef fect of d-tubocurarine [3]. In the light of our results tetracycline hydro chloride cannot produce a neuromuscular blockade.…”

“…Previous experiments on animals demonstrated that tetracycline hydro chloride, erythromycin, chloramphenicol succinate and penicillin G Potassium have no neuromuscular activity [3,14]. However, it was shown that tetracycline as well as streptomycin increase the curarizing ef fect of d-tubocurarine [3].…”

“…From previous experimental studies it is known that the neuromuscu lar transmission is disturbed after administration of neomycin, streptomy cin, polymyxin B sulfate and colistin sulfate [1,3,14].…”

The Effect of Streptomycin and Colistin on Myasthenic Patients

“…From previous experiments it is known that neomycin sulfate, strepto mycin and dihydrostreptomycin sulfate, polymyxin A and B sulfate, colis tin sulfate and viomycin sulfate interfere with the neuromuscular trans mission [1,3,13]. This blockade induced by neomycin, streptomycin and viomycin was reversed by neostigmin [1,2,5,10,11,13].…”

Respiratory Paralysis After a Large Dose of Streptomycin

“…Streptomycin has been shown to be capable of blocking neuromuscular conduction in experimental animals (Brazil and Corrado, 1957;Bezzi and Gessa, 1959), and in human intercostal nerve-muscle preparations (Sabawala and Dillon, 1959). Loder and Walker (1959) have reported three cases of muscular weakness and visual difficulty, resembling a myasthenic state, in patients receiving standard intramuscular doses of streptomycin.…”