Neuromuscular adaptations to long-term progressive resistance training translates to improved functional capacity for people with multiple sclerosis and is maintained at follow-up

Kjølhede, Tue; Vissing, Kristian; Place, Line de; Pedersen, Birthe D.; Ringgaard, Steffen; Stenager, Egon; Petersen, Thor; Dalgas, Ulrik

doi:10.1177/1352458514549402

Cited by 77 publications

(85 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This deficit is due to deficient muscle mechanical parameters related to both neural [6,11] and structural [12] mechanisms. Indeed, previous studies have shown loss of muscle mass, abnormal distribution of muscle fiber types, reduced ability to fully activate motor units, and reduced rate of force development in patients with MS when compared with nondisabled controls [5,13].…”

Section: Introductionmentioning

confidence: 96%

Effects of high-speed power training on muscle strength and power in patients with multiple sclerosis

et al. 2016

View full text Add to dashboard Cite

Abstract-This study examined the effects of a high-speed power training program in peak muscle power and maximal voluntary isometric contraction (MVIC) of knee extensors in patients with relapsing-remitting multiple sclerosis (MS). Forty patients, 20 women (age 42.8 +/-10.3 yr) and 20 men (age 44.0 +/-8.7 yr) diagnosed with relapsing-remitting MS were randomly assigned, with respect to sex, to either an exercise group or a control group. Participants from the exercise group performed 12 wk of supervised muscle power training of knee extensors. All subjects were tested for MVIC and peak muscle power at baseline and after the training intervention. A strain gauge was used to measure the MVIC, and peak muscle power was assessed with a linear encoder at five relative loads. The training-related effects were assessed using a t-test. The results showed no significant changes in the control group from baseline to postintervention evaluation. In contrast, the exercise group significantly increased MVIC (10.8%; p < 0.05) and muscle power at 40,50, 60, 70, and 80% of the MVIC by 21.8, 14.5, 17.3, 19.4,and 22.3%, respectively (p < 0.01), after the training. These findings suggest that 12 wk of high-speed power training improve both MVIC and muscle power at five different loads in patients with relapsing-remitting MS.

show abstract

Section: Introductionmentioning

confidence: 96%

Effects of high-speed power training on muscle strength and power in patients with multiple sclerosis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Given the influence of ambulation on everyday life activities, gait impairment has been a target of rehabilitation strategies and of dalfampridine, a broad spectrum potassium channel blocker that is the only US Food and Drug Administration-approved symptomatic treatment for gait disturbances. 2–4 …”

Section: Introductionmentioning

confidence: 99%

Relationship between timed 25-foot walk and diffusion tensor imaging in multiple sclerosis

Klineova

Farber

Saiote

et al. 2016

Multiple Sclerosis Journal - Experimental, Translational and Cl

View full text Add to dashboard Cite

Objective/BackgroundThe majority of multiple sclerosis patients experience impaired walking ability, which impacts quality of life. Timed 25-foot walk is commonly used to gauge gait impairment but results can be broadly variable. Objective biological markers that correlate closely with patients’ disability are needed. Diffusion tensor imaging, quantifying fiber tract integrity, might provide such information. In this project we analyzed relationships between timed 25-foot walk, conventional and diffusion tensor imaging magnetic resonance imaging markers.Design/MethodsA cohort of gait impaired multiple sclerosis patients underwent brain and cervical spinal cord magnetic resonance imaging. Diffusion tensor imaging mean diffusivity and fractional anisotropy were measured on the brain corticospinal tracts and spinal restricted field of vision at C2/3. We analyzed relationships between baseline timed 25-foot walk, conventional and diffusion tensor imaging magnetic resonance imaging markers.ResultsMultivariate linear regression analysis showed a statistically significant association between several magnetic resonance imaging and diffusion tensor imaging metrics and timed 25-foot walk: brain mean diffusivity corticospinal tracts (p = 0.004), brain corticospinal tracts axial and radial diffusivity (P = 0.004 and 0.02), grey matter volume (p = 0.05), white matter volume (p = 0.03) and normalized brain volume (P = 0.01). The linear regression model containing mean diffusivity corticospinal tracts and controlled for gait assistance was the best fit model (p = 0.004).ConclusionsOur results suggest an association between diffusion tensor imaging metrics and gait impairment, evidenced by brain mean diffusivity corticospinal tracts and timed 25-foot walk.

show abstract

“…Regular exercise can improve daily activity 8 , cardiovascular fitness 8;9 , muscle strength 10 , and fatigue 8;11 in people with MS 12 . Strength training is known to promote neural adaptations that can lead to favorable functional outcomes in MS participants [13][14][15][16] . Since physical rehabilitation is often the only treatment offered to individuals with MS for recovery of function, it is critical to determine what is the most efficient way to improve strength.…”

Section: Introductionmentioning

confidence: 99%

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Keller

Fritz

Chiang

et al. 2016

JoVE

View full text Add to dashboard Cite

Hip weakness is a common symptom affecting walking ability in people with multiple sclerosis (MS). It is known that resistance strength training (RST) can improve strength in individuals with MS, however; it remains unclear the duration of RST that is needed to make strength gains and how to adapt hip strengthening exercises for individuals of varying strength using only resistance bands. This paper describes the methodology to set up and implement an adapted resistance strength training program, using resistance bands, for individuals with MS. Directions for preand post-strength tests to evaluate efficacy of the strength-training program are included. Safety features and detailed instructions outline the weekly program content and progression. Current evidence is presented showing that significant strength gains can be made within 8 weeks of starting a RST program. Evidence is also presented showing that resistance strength training can be successfully adapted for individuals with MS of varying strength with little equipment. Video LinkThe video component of this article can be found at

show abstract

Neuromuscular adaptations to long-term progressive resistance training translates to improved functional capacity for people with multiple sclerosis and is maintained at follow-up

Abstract: Compelling evidence is provided, that PRT performed over sufficiently long periods, improves functional capacity, likely due to neuromuscular adaptations.

Cited by 77 publications

References 35 publications

Effects of high-speed power training on muscle strength and power in patients with multiple sclerosis

Effects of high-speed power training on muscle strength and power in patients with multiple sclerosis

Relationship between timed 25-foot walk and diffusion tensor imaging in multiple sclerosis

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Contact Info

Product

Resources

About