Abstract:Control of neurotransmission efficacy is central to theories of how the brain computes and stores information. Neuromodulators are critical in this problem as they locally influence synaptic strength and can operate on a wide range of time scales. Presynaptic function is heavily influenced by G-protein coupled receptors (GPCRs) that in part restrict voltage-gated calcium (Ca2+) influx in the active zone. Here, using quantitative analysis of both single bouton Ca2+ influx and exocytosis, we uncovered an unexpec… Show more
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