Neuromodulatory control of hippocampal function: towards a model of Alzheimer’s disease

Simulations of the Role of the Muscarinic-Activated Calcium-Sensitive Nonspecific Cation CurrentINCMin Entorhinal Neuronal Activity during Delayed Matching Tasks

“…As shown in Figure 4, this sustained spiking activity can withstand short periods of hyperpolarization which could result from distractor stimuli. The muscarinic enhancement of the I NCM current may be further enhanced by the blockade of potassium currents, which makes the cell more electrotonically compact (Menschik and Finkel, 1998) (Alonso, unpublished observations). This would allow somatic generated spikes to more strongly activate dendritic calcium channels, and thereby further enhance the activation of dendritic I NCM currents.…”

<title>Knowledge-based localization of hippocampus in human brain MRI</title>

“…1(c)). Details of the hippocampus neurophysiology, anatomy and its appearance on MRI are presented in various publications [2], [17], [19]- [22].…”

Improving Associative Memory in a Network of Spiking Neurons

“…Comparable to research on simple artificial neural nets, Sommer and Wennekers studied the range of high memory capacity, robustness of efficient retrieval with varied memory load, the excitation/inhibition parameters and the background activity. Other biologically based networks in the field explore principles less comparable to optimally tuned formal associative memory Jensen, Idiart and Lisman, 1996;Menschik and Finkel, 1998). Sommer and Wennekers (2001) used the two-compartment neuron model of Pinsky and Rinzel (1994), see chapter 3, section 3.1 for exact dynamic equations and parameter settings.…”

“…It is argued that complicated cellular structures (Large multi-compartmental models) add more biological plausibility to a model, but also bring inherent complications through increased parameters and parameter ranges. Menschik and Finkel (1998) proposed an attractor associative memory as a model for the CA3 region in the hippocampus. In their model, memories are expressed by synchronized gamma activity persisting over a theta cycle.…”

“…In their model, memories are expressed by synchronized gamma activity persisting over a theta cycle. By developing this model Menschik and Finkel (1998) investigate the role of Alzheimer's 58 disease on physiologically realistic models with further complexity to both cellular, network and network configuration including cell numbers with context to inhibitory networks.…”