Neuromodulation Therapy for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review

D’Souza, Ryan S; Her, Yeng F.; Jin, Max Y.; Morsi, Mahmoud; Abd‐Elsayed, Alaa

doi:10.3390/biomedicines10081909

Cited by 16 publications

(11 citation statements)

References 57 publications

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“…There are currently 2 systematic reviews 18,27 of neuromodulation interventions and 4 studies [80][81][82][83] of acupuncture for CIPN similar to ours. There are similarities in the results, suggesting that such therapies reduce neuropathic pain 27,83,84 and improve patient quality of life. 81,83 It can also be combined with usual care to improve outcomes.…”

Section: Comparison Of Similar Studiesmentioning

confidence: 56%

The Efficacy of Neuromodulation Interventions for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Xu,

Yu,

Zhang

et al. 2024

JPR

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To determine the efficacy and safety of a neuromodulation intervention regimen in the treatment of chemotherapy-induced peripheral neuropathy (CIPN). Patients and Methods: Systematic searches were conducted in seven English databases. Randomized controlled trials of all neuromodulation interventions (both invasive and non-invasive) for the treatment of CIPN were selected. Group comparisons of differences between interventions and controls were also made. We divided the outcomes into immediate-term effect (≤3 weeks), short-term effect (3 weeks to ≤3 months), and long-term effect (>3 months). Results: Sixteen studies and 946 patients with CIPN were included. Among immediate-term effects, neuromodulation interventions were superior to usual care for improving pain (SMD=−0.77, 95% CI −1.07~ 0.47), FACT-Ntx (MD = 5.35, 95% CI 2.84~ 7.87), and QOL (SMD = 0.44, 95% CI 0.09~ 0.79) (moderate certainty); neuromodulation loaded with usual care was superior to usual care for improving pain (SMD=−0.47, 95% CI −0.71 ~ −0.23), and QOL (SMD = 0.40, 95% CI 0.12 ~ 0.69) (moderate certainty). There were no statistically significant differences between the neuromodulation interventions regimen vs usual care in short-and long-term outcomes and neuromodulation vs sham stimulation from any outcome measure. There were mild adverse events such as pain at the site of stimulation and bruising, and no serious adverse events were reported. Conclusion: Neuromodulation interventions had significant immediate-term efficacy in CIPN but had not been shown to be superior to sham stimulation; short-term and long-term efficacy could not be determined because there were too few original RCTs. Moreover, there are no serious adverse effects of this therapy.

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Section: Comparison Of Similar Studiesmentioning

confidence: 56%

The Efficacy of Neuromodulation Interventions for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Xu,

Yu,

Zhang

et al. 2024

JPR

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“…Neuropathic pain tends to have a worse prognosis and is more likely to be refractory than non-neuropathic pain [ 34 ]. The damage can be in the form of a lesion to peripheral or central nerve fibers or as a result of disease (e.g., diabetes, cancer) [ 35 – 37 ]. This type of non-protective pain has a high degree of variability from person to person and is stimulus-independent [ 38 ].…”

Section: Neuropathic Painmentioning

confidence: 99%

Microbiological and Physiological Effects of Pain

Jin

Everett

Abd‐Elsayed

2023

Curr Pain Headache Rep

Self Cite

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Pain is an important innate defense mechanism that can dramatically alter a person’s quality of life. Understanding the microbiological and physiological effects of pain may be important in the pursuit of novel pain interventions. The three descriptors of pain recognized by the International Association for the Study of Pain are nociceptive, neuropathic, and nociplastic pain. Our review examined the current understanding of all three pain types, focusing on the key molecules involved in the manifestation of each type as well as physiological effects. Additionally, we compared the differences in painful and painless neuropathies and discussed the neuroimmune interaction involved in the manifestation of pain.

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“…Spinal Cord Stimulation (SCS) and dorsal root ganglion stimulation provide pain relief in neuropathic pain but studies dedicated to cancer pain are missing. Data are promising, with pain relief of at least 50%, but only case reports have been published up to now [62,64,65].…”

Section: Personalized Treatment: Is It Possible?mentioning

confidence: 99%

Cancer Pain Management - Current Concepts, Strategies and Management Techniques

Mestdagh¹,

Steyaert²,

Lavand’homme³

2023

Preprint

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Pain is frequently reported during cancer disease, and still remains poorly controlled in 40% of patients. Recent developments in oncology have helped to better control pain. Targeted treatments may cure cancer disease and significantly increase survival. Thereby, a novel population of patients (cancer survivors) has emerged, also enduring chronic pain (27.6% moderate to severe pain). The present review discuss the different options currently available to manage pain in (former) cancer patients in the light of progress made in the last decade. Major progress in the field are recent development of a chronic cancer pain taxonomy now included in International Classification of Diseases (ICD-11) and update of WHO analgesic ladder. Until recently, cancer pain management has mostly relied on pharmacotherapy, opioids being considered as mainstay. The opioids crisis has prompted the reassessment of opioids use, both in cancer patients and cancer survivors. The review focuses on the current utilization of opioids, on the neuropathic pain component often neglected and on techniques and non-pharmacological strategies available which help to personalize patient’s treatment. Cancer pain management is now closer to the management of chronic non-cancer pain i.e. “an integrative pain care” aiming to improve patient’s quality of life.

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Neuromodulation Therapy for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review

Cited by 16 publications

References 57 publications

The Efficacy of Neuromodulation Interventions for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

The Efficacy of Neuromodulation Interventions for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Microbiological and Physiological Effects of Pain

Cancer Pain Management - Current Concepts, Strategies and Management Techniques

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