Neuromodulating Action of Cimicifuga racemosa for Alleviation of Vasomotor Symptoms

Nicken, Petra; Zepelin, Hans-Heinrich Henneicke-von; Kuchernig, JC; Pickartz, S.; Naser, N; Nolte, Klaus-Ulrich

doi:10.1055/s-0039-1697296

Cited by 2 publications

(1 citation statement)

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“…The analysis of the mode of action for CR is very difficult because the multicomponent herbal preparation—the extract—performs many different individual actions. As previously hypothesized, there is a multi-target mode of action and the resulting effect is that CR restores imbalanced functions and mitigates menopausal symptoms by a multifaceted mechanism [ 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Gene expression analyses on multi-target mode of action of black cohosh in menopausal complaints – a pilot study in rodents

Stute¹,

Ehrentraut

Zepelin

et al. 2021

Arch Gynecol Obstet

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Purpose This study aimed at assessing gene expression profiles in hippocampus and hypothalamus of ovariectomized (OVX) rats with or without treatment with an isopropanolic extract of Cimicifuga racemosa rhizomes (iCR) in comparison to intact rats. Methods Exploration of hippocampal (Hi) and hypothalamic (Hy) tissue from Sprague Dawley rats: without OVX (NHi = NHy = 4), tissues 3 months after OVX (NHi = 4, NHy = 3), or tissues of rats after their treatment with iCR for 3 months after OVX (NHi = NHy = 2). Gene expression profiles in these tissues were investigated by RNA-microarray-analysis and subsequent verification by qPCR. Results 4812 genes were differentially regulated when comparing the three groups in hippocampus and hypothalamus. iCR compensated the effects of OVX in 518 genes. This compensatory effect was most prominent in hippocampal signalling pathways, thereof genes (GAL, CALCA, HCRT, AVPR1A, PNOC, etc.) involved in thermoregulation, regulation of sleep and arousal, blood pressure regulation, metabolism, nociception, hormonal regulation, homeostasis, learning and cognition, mood regulation, neuroendocrine modulation, etc.. In the hypothalamus, iCR compensated OVX-effects at TAC3 and OPRM1 but not at KISS1. These genes are involved in the pathophysiology of hot flashes. Conclusions Our pilot study findings support a multifaceted mode of action of iCR in menopausal complaints on a tissue-specific brain gene expression level.

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Section: Discussionmentioning

confidence: 99%