Neurometabolomic Impacts of Modeled Wildfire Smoke and Protective Benefits of Anti-Aging Therapeutics in Aged Female C57bl/6j Mice
David Scieszka,
Haiwei Gu,
Amanda Barkley-Levenson
et al.
Abstract:Wildland fires have become progressively more extensive over the past 30 years in the US, and now routinely generate smoke that deteriorates air quality for most of the country. We explored the neurometabolomic impact that smoke derived from biomass has on older (18 months) female C57BL/6J mice, both acutely and after 10 weeks of recovery from exposures. Mice (N=6/group) were exposed to wood smoke (WS) 4 hours/day, every other day, for 2 weeks (7 exposures total) to an average concentration of 0.448mg/m3 per e… Show more
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