Neuromarkers of anxiety and depression in a patient after neuro-ophthalmic surgery of the meningioma – effect of individually-tailored tDCS and neurofeedback

Abstract

of anxiety and depression in a patient after neuro-ophthalmic surgery of the meningioma -effect of individually-tailored tDCS and neurofeedback. Ann Agric Environ Med. 2015; 22(4): 718-723. doi: 10.5604/12321966.1185783 AbstractThe aim of the study was to evaluate the effectiveness of individually tailored anodal tDCs/ neurofeedback protocol for the reduction of post-operative depression after a neuroophtalmological operation of the meningioma. The neuromarkers in Quantitative EEG (QEEG) and Event-related potentials (ERPs) were utilized in the construction of protocol and evaluation. Case description. A 45-year-old female after successful neuro-ophthalmic surgery of the meningioma, complained of severe pain and anxiety, difficulties with sleeping, attention and memory problems, as well as inability to continue working in her given profession. Neuropsychological testing showed lack of cognitive disturbances and post-operative depression. Two working hypotheses were tested to find neuromarkers of depression and anxiety. In line with the 'depression hypothesis' a frontal alpha asymmetry pattern was found in the patient, and in line with the 'anxiety' hypothesis an increased left temporal P1 wave in response to visual stimuli was found in ERPs. A specific alpha asymmetry neurofeedback protocol combined with an anodal tDCS was suggested. Twenty sessions of individually-tailored anodal tDCs/ neurofeedback protocol were performed. The QEEG frontal asymmetry pattern and the excessive temporal P1 wave were normalized after the intervention. Conclusions. The patient recovered from post-operative depression and returned to work after 20 sessions of the combined neurofeedback/tDCS protocol. Specific patterns of QEEG and ERPs serve as neuromarkers for constructing the protocol and for monitoring the results of intervention.

Differences in the expression of selected genes associated with cell stress response in a PTSD patient and in healthy individuals – a case study

“…There is available within the subject literature research suggesting disturbances to the immune system in certain diseases, such as schizophrenia [8,9,10], depression [11,12,13], anorexia [14,15] or OCD [16]. Freudenreich et al [9] suggest that disturbances to the immune system in schizophrenia are linked to a reduced level in cell response, and an increase in the humoral response.…”

“…The research available within the subject literature connected with gene expression is chiefly concerned with disturbances, such as schizophrenia [8,9,10], depression [11,12,13], anorexia [14,15] or OCD [16]. The cited authors tested genes connected to the immunological response, chiefly that of interleukins, and suggest that disturbance to the immune system in schizophrenia is connected with a reduction in the cell response and an increase in the humoral.…”

Transcranial alternating current stimulation for the treatment of major depressive disorder: from basic mechanisms toward clinical applications

“…Moreover, accumulating intervention studies have provided evidence of a causal relationship between FAA and MDD. For example, targeting to decrease the FAA, studies adapted neurofeedback training ( Peeters et al, 2014 ; Mirski et al, 2015 ; Wang et al, 2016 ), tDCS ( Mirski et al, 2015 ; Al-Kaysi et al, 2017 ; Carvalho et al, 2020 ), and repetitive TMS (rTMS) ( Olejarczyk et al, 2021 ) have found symptoms alleviations in MDD patients. Regarding the abnormal FAA in MDD patients, some recent studies explored whether it could predict the response to medication treatments but found mixed results ( Baskaran et al, 2018 ), and a meta-analysis suggested that individual differences (such as sex and age), clinical characteristics (such as medication and comorbidities), and specific measurements (such as electrode selection and normalization methods) affected FAA in MDD patients ( Van Der Vinne et al, 2017 ), indicating that it is essential to consider more factors when discussing abnormal FAA in MDD patients.…”

Precision non-implantable neuromodulation therapies: a perspective for the depressed brain

“…70,78 Furthermore, electrical stimulation with different wave formats, such as transcranial alternating current stimulation (tACS) 79 or transcranial random noise stimulation (tRNS), 80 could be used to target MDD-related oscillatory brain activity in the DLPFC, possibly in combination with individualized neurofeedback strategies. 81…”