Neuromagnetic Responses to Frequency-Tagged Sounds: A New Method to Follow Inputs from Each Ear to the Human Auditory Cortex during Binaural Hearing

Fujiki, Nobuya; Jousmäki, Veikko; Hari, Riitta

doi:10.1523/jneurosci.22-03-j0003.2002

Cited by 74 publications

(73 citation statements)

References 25 publications

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“…In healthy control subjects-in line with previous results (Fujiki et al, 2002;Kaneko et al, 2003)-the sinusoidal steady-state auditory-cortex responses to amplitude modulated tones (Fig. 2C, top) were smaller to binaural (dashed lines) than monaural (solid lines) stimulation, especially for inputs from the ipsilateral ear.…”

Section: Binaural Suppressionsupporting

confidence: 91%

“…2 B). The tagged auditory-cortex responses were selectively extracted from each hemisphere with magnetoencephalography with a method previously developed in our laboratory (Fujiki et al, 2002;Kaneko et al, 2003). By means of the modulation frequencies, MEG signals for the left and right-ear inputs of the binaural stimuli can be separated from each other and then compared with the monaural responses to quantify the binaural suppression.…”

Section: Methodsmentioning

confidence: 99%

“…The stimulation and analysis were based on previous nonclinical studies of frequency-tagged auditory inputs (Fujiki et al, 2002;Kaneko et al, 2003). We delivered, via plastic tubes and earpieces, continuous 1 kHz tones that were amplitude modulated with 100% depth at 41.1 Hz in the left ear and at 39.1 Hz in the right ear (Fig.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, the auditory cortices of each hemisphere receive input from both ears. Cortical steady-state responses to sounds from one ear are weaker during binaural than monaural listening, indicating binaural suppressive interaction (Fujiki et al, 2002;Kaneko et al, 2003). The suppression is stronger for ipsilateral than contralateral sounds and requires convergence of the inputs from both ears somewhere in the auditory pathways.…”

Section: Introductionmentioning

confidence: 99%

“…We studied binaural suppression-and thereby indirectly the strength of crossing in auditory pathways-in individuals with the ROBO1 gene defect by "frequency-tagging" magnetoencephalographic (MEG) steady-state responses, a method used previously in nonclinical studies (Fujiki et al, 2002;Kaneko et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

HumanROBO1Regulates Interaural Interaction in Auditory Pathways

et al. 2012

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In rodents, the Robo1 gene regulates midline crossing of major nerve tracts, a fundamental property of the mammalian CNS. However, the neurodevelopmental function of the human ROBO1 gene remains unknown, apart from a suggested role in dyslexia. We therefore studied axonal crossing with a functional approach, based on magnetoencephalography, in 10 dyslexic individuals who all share the same rare, weakly expressing haplotype of the ROBO1 gene. Auditory-cortex responses were recorded separately to left-and right-ear sounds that were amplitude modulated at different frequencies. We found impaired interaural interaction that depended on the ROBO1 in a dosedependent manner. Our results indicate that normal crossing of the auditory pathways requires an adequate ROBO1 expression level.

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Section: Binaural Suppressionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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HumanROBO1Regulates Interaural Interaction in Auditory Pathways

et al. 2012

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Fast periodic visual stimulation to highlight the relationship between human intracerebral recordings and scalp electroencephalography

Jacques

Jonas

Maillard

et al. 2020

Human Brain Mapping

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Despite being of primary importance for fundamental research and clinical studies, the relationship between local neural population activity and scalp electroencephalography (EEG) in humans remains largely unknown. Here we report simultaneous scalp and intracerebral EEG responses to face stimuli in a unique epileptic patient implanted with 27 intracerebral recording contacts in the right occipitotemporal cortex. The patient was shown images of faces appearing at a frequency of 6 Hz, which elicits neural responses at this exact frequency. Response quantification at this frequency allowed to objectively relate the neural activity measured inside and outside the brain. The patient exhibited typical 6 Hz responses on the scalp at the right occipitotemporal sites. Moreover, there was a clear spatial correspondence between these scalp responses and intracerebral signals in the right lateral inferior occipital gyrus, both in amplitude and in phase. Nevertheless, the signal measured on the scalp and inside the brain at nearby locations showed a 10-fold difference in amplitude due to electrical insulation from the head. To further quantify the relationship between the scalp and intracerebral recordings, we used an approach correlating time-varying signals at the stimulation frequency across scalp and intracerebral channels. This analysis revealed a focused and right-lateralized correspondence between the scalp and intracerebral recordings that were specific to the face stimulation is more broadly distributed in various control situations. These results demonstrate the interest of a frequency tagging approach in characterizing the electrical propagation from brain sources to scalp EEG sensors and in identifying the cortical sources of brain functions from these recordings. K E Y W O R D S face perception, frequency tagging, inferior occipital gyrus, intracerebral electrophysiology, occipitotemporal, SEEG, source imaging, vision † Bruno Rossion and Laurent Koessler contributed equally to this work.

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Cortical imbalance following delayed restoration of bilateral hearing in deaf adolescents

Anderson

Cushing

Papsin

et al. 2022

Human Brain Mapping

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Unilateral auditory deprivation in early childhood can lead to cortical strengthening of inputs from the stimulated side, yet the impact of this on bilateral processing when inputs are later restored beyond an early sensitive period is unknown. To address this, we conducted a longitudinal study with 13 bilaterally profoundly deaf adolescents who received unilateral access to sound via a cochlear implant (CI) in their right ear in early childhood before receiving bilateral access to sound a decade later via a second CI in their left ear. Auditory-evoked cortical responses to unilateral and bilateral stimulation were measured repeatedly using electroencephalogram from 1 week to 14 months after activation of their second CI. Early cortical responses from the newly implanted ear and bilateral stimulation were atypically lateralized to the left ipsilateral auditory cortex. Duration of unilateral deafness predicted an unexpectedly stronger representation of inputs from the newly implanted, compared to the first implanted ear, in left auditory cortex. Significant initial reductions in responses were observed, yet a left-hemisphere bias and unequal weighting of inputs favoring the long-term deaf ear did not converge to a balanced state observed in the binaurally developed system. Bilateral response enhancement was significantly reduced in left auditory cortex suggesting deficits in ipsilateral response inhibition of new, dominant, inputs during bilateral processing. These findings paradoxically demonstrate the adaptive capacity of the adolescent auditory system beyond an early sensitive period for bilateral input, as well as restrictions on its potential to fully reverse cortical imbalances driven by long-term unilateral deafness.

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Neuromagnetic Responses to Frequency-Tagged Sounds: A New Method to Follow Inputs from Each Ear to the Human Auditory Cortex during Binaural Hearing

Cited by 74 publications

References 25 publications

HumanROBO1Regulates Interaural Interaction in Auditory Pathways

HumanROBO1Regulates Interaural Interaction in Auditory Pathways

Fast periodic visual stimulation to highlight the relationship between human intracerebral recordings and scalp electroencephalography

Cortical imbalance following delayed restoration of bilateral hearing in deaf adolescents

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