“…They have provided evidence of altered functional connectivity (FC) of the default mode network (DMN) (Fallon et al, 2016 ) and cognitive control network in FMS patients compared to healthy controls (Kong et al, 2018 ), as well as changes in the aforementioned networks following transcranial direct current stimulation to the motor cortex (Cummiford et al, 2016 ), cognitive behavioural therapy (Jensen et al, 2012a , b , c ), hypnosis (Derbyshire et al, 2009 ) or mindfulness (Young et al, 2018 ). The amygdala seems to play a key role in encoding major targets of psychological therapies for chronic pain, such as depression (Giesecke et al, 2005 ) or anxiety and fear of pain (Hsiao et al, 2020 ). Studies using sustained-pain BOLD fMRI paradigms point towards FC increases of the somatosensory cortex with the insula during pain in FMS patients (Kim et al, 2015 ) which can be altered with cognitive therapy (Lazaridou et al, 2017 ); they also suggest that there is less FC within the pain inhibitory network during pressure pain, using the rostral anterior cingulate cortex (ACC) as seed (Jensen et al, 2012a , b , c ).…”