Neurolymphomatosis on 18F-FDG PET/CT

Gykiere, Pieterjan; Jans, Lennart; Degrieck, Bert; Goethals, Ingeborg

doi:10.1097/rlu.0000000000000982

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Targeted MRI neurography at sites of hypermetabolism can be expected to substantially further improve the anatomical characterization of intraneural invasion. In addition, 18 FDG-PET has been demonstrated to be helpful in monitoring the response to therapy [30, 31].…”

Section: Discussionmentioning

confidence: 99%

Neurolymphomatosis of the lumbosacral plexus and its branches: case series and literature review

et al. 2019

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BackgroundNeurolymphomatosis (NL) is a direct process of invasion of peripheral nerves by lymphoma. It occurs in roughly 5% of patients with lymphoma and represents a particularly difficult diagnostic dilemma when it is the presenting focal manifestation of occult lymphoma.Case presentationWe present 3 examples of invasion of the lumbosacral plexus and its branches. These cases demonstrate a protean clinical picture with regards to the time relationship to the clinical course of lymphoma and the neuroanatomical extent of lumbosacral plexus invasion. We demonstrate the complementary role of different imaging modalities. A review of the literature summarizes 23 reports where lumbosacral plexus invasion was the index manifestation, at the time of first diagnosis or recurrence of lymphoma. This series confirms the strong preponderance of B-cell type (92%). There is a marked predilection for involvement of the sciatic nerve (74%), either focally or in a longitudinally extensive fashion, from the ischium to the popliteal fossa. There can also be restricted and discrete involvement of tibial and fibular branches. In recent years, ultrasound and CT have been given a more limited role, as screening tools or as a guide for biopsy. MRI neurography and PET-CT have become leading diagnostic modalities for diagnosis, staging and assessment of treatment response.ConclusionThe diagnosis of NL may be challenging, and it was once only reached at autopsy. Improved diagnostic imaging of focal or even asymptomatic disease offers new hope for earlier diagnosis and successful targeted therapy.

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Section: Discussionmentioning

confidence: 99%

Neurolymphomatosis of the lumbosacral plexus and its branches: case series and literature review

et al. 2019

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“…18 Several studies demonstrate the usefulness of 18 F-FDG PET in response assessment of NL after chemotherapy. 19,20 Conclusions 18 F-FDG PET-CT is a sensitive imaging modality for the detection of neurolymphomatosis lesions. It helps in the initial diagnosis, staging, guiding biopsy, treatment planning, response assessment, and prognostication of the disease.…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

The role of 18F-FDG PET/CT in Neurolymphomatosis: A Comprehensive Imaging Approach

Sharjeel Usmani,

Anjali Jain,

Khulood Al Riyami

et al. 2024

J Pak Med Assoc

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Neurolymphomatosis (NL) is an uncommon and rare neurologic disorder characterised by extranodal lymphoma, where the tumour cells invade the cranial nerves, nerve plexus, nerve root, spinal nerve roots, trunk nerves or peripheral nerves. MRI is the modality of choice, but is often challenging in detection of early recurrence, assessing residual disease and response evaluation. 18F-FDG PET/CT has superior diagnostic performance compared with body CT in the evaluation of NL. 18F-FDG PET-CT is helpful in evaluation of disease extent and potential to guide biopsy. 18F-FDG PETCT is a highly sensitive technique for early localisation of NL than MRI or CT alone. Besides diagnostic and prognostic value in NL, it might be very helpful in response assessment. Key Words: 18F-FDG PET/CT; Neurolymphomatosis; peripheral nervous system.

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Neurolymphomatosis on 18F-FDG PET/CT

Cited by 2 publications

References 8 publications

Neurolymphomatosis of the lumbosacral plexus and its branches: case series and literature review

Neurolymphomatosis of the lumbosacral plexus and its branches: case series and literature review

The role of 18F-FDG PET/CT in Neurolymphomatosis: A Comprehensive Imaging Approach

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