Neurologischer Reha-Score

Thilmann, A. F.; Nachtmann, Andreas; Scharff, A.

doi:10.1007/s00115-006-2167-y

Cited by 4 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are some data on the IT administration of cephaloridine, a first-generation cephalosporin that is no longer available for therapeutic use possibly due to renal toxicity. Furthermore, two cases on the use of ceftazidime have been described, as well as two cases in which the cephalosporin was dosed extremely high after an error in the preparation of the solution or the administration [ 65 , 85 , 93 ].…”

Section: Resultsmentioning

confidence: 99%

“…Two cases have been described who were treated with intraventricular ceftazidime in doses of 10–20 mg twice per week. One patient with P. aeruginosa meningitis, who was treated as an out-patient for nearly two years, died after an attempted withdrawal of the intraventricular treatment [ 85 ]. The other patient was cured from a ventriculitis with an unknown pathogen after 16 IT doses of ceftazidime.…”

Section: Resultsmentioning

confidence: 99%

“…The other patient was cured from a ventriculitis with an unknown pathogen after 16 IT doses of ceftazidime. Both patients did not have irreversible side effects [ 85 ].…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Experience with Off-Label Intrathecal Administration of Selected Antibiotics in Adults: An Overview with Pharmacometric Considerations

2023

View full text Add to dashboard Cite

Drain-associated intracerebral infections are life-threatening emergencies. Their treatment is challenging due to the limited penetration of antibiotics to the site of infection, resulting in potentially inadequate exposure. The emergence of multidrug-resistant pathogens might force the use of off-label intrathecal (IT) doses of antibiotics. We reviewed the literature on general aspects determining intrathecal dosing regimen, using pharmacometric knowledge. We summarised clinical experience with IT doses of antibiotics that are usually not used intrathecally, as well as the outcome of the cases and concentrations reached in the cerebrospinal fluid (CSF). Factors determining the IT regimen are the size of the ventricle system and the CSF drainage volume. With regard to pharmacometrics, pharmacokinetic/pharmacodynamic indices are likely similar to those in non-cerebral infections. The following number (N) of cases were described: benzylpenicillin (>50), ampicillin (1), ceftazidime (2), cephaloridine (56), ceftriaxone (1), cefotiam (1), meropenem (57), linezolid (1), tigecycline (15), rifampicin (3), levofloxacin (2), chloramphenicol (3) and daptomycin (8). Many side effects were reported for benzylpenicillin in the 1940–50s, but for the other antibiotics, when administered correctly, all side effects were minor and reversible. These data might help when choosing an IT dosing regimen in case there is no alternative option due to antimicrobial resistance.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Experience with Off-Label Intrathecal Administration of Selected Antibiotics in Adults: An Overview with Pharmacometric Considerations

2023

View full text Add to dashboard Cite

show abstract

“…Για να επιτύχουµε το θεραπευτικό στόχο πρέπει οι δόσεις να είναι όσο το δυνατό πιο συχνές κατά τη διάρκεια της ηµέρας ή η δόση χορήγησης να είναι όσο το δυνατό µεγαλύτερη. Και οι δύο στρατηγικές θα έχουν καλά αποτελέσµατα (238).…”

Section: ∆είκτες φαρµακοκινητικής -φαρµακοδυναµικήςunclassified

Φαρμακοκινητική Μελέτη Στο Εγκεφαλονωτιαίο Υγρό (ENY) Μετά Από Ενδοκοιλιακή Έγχυση Βανκομυκίνης Τεϊκοπλανίνης Και Νετιλμικίνης

Ιωάννου¹

View full text Add to dashboard Cite

Valid and reliable instruments for arm-hand assessment at ICF activity level in persons with hemiplegia: a systematic review

et al. 2012

View full text Add to dashboard Cite

Background Loss of arm-hand performance due to a hemiparesis as a result of stroke or cerebral palsy (CP), leads to large problems in daily life of these patients. Assessment of arm-hand performance is important in both clinical practice and research. To gain more insight in e.g. effectiveness of common therapies for different patient populations with similar clinical characteristics, consensus regarding the choice and use of outcome measures is paramount. To guide this choice, an overview of available instruments is necessary. The aim of this systematic review is to identify, evaluate and categorize instruments, reported to be valid and reliable, assessing arm-hand performance at the ICF activity level in patients with stroke or cerebral palsy. Methods A systematic literature search was performed to identify articles containing instruments assessing arm-hand skilled performance in patients with stroke or cerebral palsy. Instruments were identified and divided into the categories capacity, perceived performance and actual performance. A second search was performed to obtain information on their content and psychometrics. Results Regarding capacity, perceived performance and actual performance, 18, 9 and 3 instruments were included respectively. Only 3 of all included instruments were used and tested in both patient populations. The content of the instruments differed widely regarding the ICF levels measured, assessment of the amount of use versus the quality of use, the inclusion of unimanual and/or bimanual tasks and the inclusion of basic and/or extended tasks. Conclusions Although many instruments assess capacity and perceived performance, a dearth exists of instruments assessing actual performance. In addition, instruments appropriate for more than one patient population are sparse. For actual performance, new instruments have to be developed, with specific focus on the usability in different patient populations and the assessment of quality of use as well as amount of use. Also, consensus about the choice and use of instruments within and across populations is needed.

show abstract

Neurologischer Reha-Score

Abstract: The NRS was shown to be effective for evaluation of outcome and expenditure in neurological rehabilitation.

Cited by 4 publications

References 12 publications

Clinical Experience with Off-Label Intrathecal Administration of Selected Antibiotics in Adults: An Overview with Pharmacometric Considerations

Clinical Experience with Off-Label Intrathecal Administration of Selected Antibiotics in Adults: An Overview with Pharmacometric Considerations

Φαρμακοκινητική Μελέτη Στο Εγκεφαλονωτιαίο Υγρό (ENY) Μετά Από Ενδοκοιλιακή Έγχυση Βανκομυκίνης Τεϊκοπλανίνης Και Νετιλμικίνης

Valid and reliable instruments for arm-hand assessment at ICF activity level in persons with hemiplegia: a systematic review

Contact Info

Product

Resources

About