“…It causes respiratory disease in young horses, abortion in pregnant mares, neonatal death in foals, and myeloencephalopathy (equine herpesvirus myeloencephalopathy: EHM), resulting in a serious economic impact on the horse industry [3,4,25]. The recent increase in EHM outbreaks among horses in the U.S.A. and Europe is of major concern to the equine veterinary community, since affected animals often have a poor prognosis [6,8,[12][13][14]16]. The molecular epidemiological study conducted by Nugent et al revealed that a single non-synonymous nucleotide (nt) substitution of guanine (G) for adenine (A) at position 2254 in the viral DNA polymerase gene (encoded by open reading frame [ORF] 30), which results in a change of asparagine to aspartic acid at amino acid position 752, is significantly associated with outbreaks in which neurologic signs have been recorded [22].…”