Neurological Symptoms in Scleroderma

Bjerregaard, Beth; Højgaard, Knud

doi:10.1001/archderm.1976.01630310076022

Cited by 6 publications

(2 citation statements)

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“…[7][8][9] Subacute combined degeneration of the cord following vitamin B12 deficiency secondary to sclerodermatous involvement of the small intestine has also been recorded. 10 We describe a patient with systemic sclerosis and autonomic neuropathy and detail our investigation of the autonomic nervous system in six other patients with scleroderma and eight control patients.…”

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Autonomic neuropathy in systemic sclerosis: a case report and evaluation of six patients.

Sonnex¹,

Paice²,

White³

1986

Annals of the Rheumatic Diseases

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SUMMARY We describe a case of systemic sclerosis with sympathetic and parasympathetic neuropathy and detail autonomic testing in six further patients. Of these six patients, three showed early parasympathetic damage. None of the patients had evidence of peripheral neuropathy, and there was no correlation between the presence of autonomic dysfunction and the severity of Raynaud's phenomenon.Autonomic neuropathy has not previously been reported in systemic sclerosis to our knowledge. Autonomic neuropathy has been described in rheumatoid arthritis1 2 and systemic lupus erythematosus,3 and impotence was recently described in systemic sclerosis4 but without formal studies of autonomic function. Other neurological manifestations of systemic sclerosis have been described but are rare. A mild peripheral neuropathy has been reported.5 6 as has trigeminal neuralgia.7-9Subacute combined degeneration of the cord following vitamin B12 deficiency secondary to sclerodermatous involvement of the small intestine has also been recorded.10We describe a patient with systemic sclerosis and autonomic neuropathy and detail our investigation of the autonomic nervous system in six other patients with scleroderma and eight control patients.

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confidence: 99%

Autonomic neuropathy in systemic sclerosis: a case report and evaluation of six patients.

Sonnex¹,

Paice²,

White³

1986

Annals of the Rheumatic Diseases

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“…6 In others, it has been related to iatrogenic causes, such as polymyositis secondary to steroids. 1 In some cases, neurologic involvement was considered a complication of the disease itself, either by an indirect mechanism secondary to other organ involvement, like renal failure that can induce encephalopathy or neuropathy, gastrointestinal involvement that cause malabsorption and can induce myelopathy, peripheral neuropathy or seizures; 7,8 or by a direct mechanism with primary pathologic processes in the nervous system. 1 Hypotheses suggested in this latter case included vascular mechanism with endothelial changes and platelet aggregation that cause tissue ischaemia; dysimmune mechanisms considering the association of systemic sclerosis with other immune-mediated disease like thyroiditis, myasthenia gravis and insulin-dependent diabetes; and entrapment mechanisms caused by fibrotic processes in cases of peripheral neuropathy.…”

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confidence: 99%