“…6 In others, it has been related to iatrogenic causes, such as polymyositis secondary to steroids. 1 In some cases, neurologic involvement was considered a complication of the disease itself, either by an indirect mechanism secondary to other organ involvement, like renal failure that can induce encephalopathy or neuropathy, gastrointestinal involvement that cause malabsorption and can induce myelopathy, peripheral neuropathy or seizures; 7,8 or by a direct mechanism with primary pathologic processes in the nervous system. 1 Hypotheses suggested in this latter case included vascular mechanism with endothelial changes and platelet aggregation that cause tissue ischaemia; dysimmune mechanisms considering the association of systemic sclerosis with other immune-mediated disease like thyroiditis, myasthenia gravis and insulin-dependent diabetes; and entrapment mechanisms caused by fibrotic processes in cases of peripheral neuropathy.…”