Neurological symptoms associated with COVID-19 based on a nation-wide online survey

Dvořáková, Tereza; Bušková, Jitk; Bartoš, Aleš

doi:10.48095/cccsnn2022220

Cited by 2 publications

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“…The final number of participants ( n = 91) was randomly divided into two subgroups (group pro biotics first, pla cebo later PROPLA (A): n = 47, group pla cebo first, pro biotics later PLAPRO (B): n = 44). A small subgroup of participants refused to come to in-person assessments due to fear of COVID-19 during the pandemic in the Czech Republic ( Dvořáková et al, 2022 ). Therefore, they participated online ( n = 19; online group A PROPLA: n = 7, online group B PLAPRO: n = 12).…”

Section: Participants and Methodsmentioning

confidence: 99%

Effects of human probiotics on memory and psychological and physical measures in community-dwelling older adults with normal and mildly impaired cognition: results of a bi-center, double-blind, randomized, and placebo-controlled clinical trial (CleverAge biota)

Bartoš¹,

Weinerova²,

Diondet³

2023

Front. Aging Neurosci.

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ObjectivesThis study presents results of our randomized clinical trial studying the effect of human probiotics on memory and psychological and physical measures following our study protocol registered at clinicaltrials.gov NCT05051501 and described in detail in our previous paper.MethodsCommunity dwelling participants aged between 55 and 80 years were randomly assigned to receive a single dose of 106 colony-forming units of human Streptococcus thermophilus GH, Streptococcus salivarius GH NEXARS, Lactobacilus plantarum GH, and Pediococcus pentosaceus GH or placebo. A cross-over design allowed each group to receive probiotics and placebo for 3 months each in reverse order. A small subset of participants was examined online due to the COVID-19 pandemic. After 6 months a small number of volunteers were additionally assessed after 2 months without any intervention. Primary outcome measures included changes in cognitive functions assessed using brief tests and a neuropsychological battery and changes in mood assessed using validated questionnaires. Secondary outcome measures included changes in self-report and subjective measures using depression and anxiety questionnaires, seven visual analog scales of subjective feelings (memory, digestion, etc.), and physical performance.ResultsAt baseline, the probiotic-placebo group A (n = 40, age 69 ± 7 years, education 16 ± 3 years, 63% females, body mass index 28.5 ± 6, subjective memory complaint in 43%) did not differ from the placebo-probiotic group B (n = 32) in any of the sociodemographic characteristics and evaluated measures including cognitive status. At follow-up visits after 3, 6, and 8 months, no cross-sectional differences in any of the measures were found between the groups except worse sentence recall of the ALBA test after 3 months of probiotic use. Score changes were not observed for all cognitive tests but one in any group between visits 1 and 3 and between visits 3 and 6. The only change was observed for the TMT B test after the first three months but no change was observed after the second three months.ConclusionThe treatment with human probiotics and prebiotics did not improve cognitive, affective, or physical measures in community-dwelling individuals with normal or mildly impaired cognitive functions.Clinical trial registrationclinicaltrials.gov, identifier NCT05051501.

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Section: Participants and Methodsmentioning

confidence: 99%

Effects of human probiotics on memory and psychological and physical measures in community-dwelling older adults with normal and mildly impaired cognition: results of a bi-center, double-blind, randomized, and placebo-controlled clinical trial (CleverAge biota)

Bartoš¹,

Weinerova²,

Diondet³

2023

Front. Aging Neurosci.

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“…According to research conducted before the COVID-19 pandemic, almost 1/3 of older adults in Europe suffered from sleep problems (van de Straat and Bracke 2015). The number increased to 3/4 in individuals after the COVID-19 disease (Dvořáková et al 2022). However, it is important to distinguish between sleep problems and natural agerelated sleep changes, as there is no causality between older age and sleep disturbance (Rodriguez et al 2015).…”

Section: Introductionmentioning

confidence: 99%

The impact of sleep education, light intervention and relaxation on sleep and mood in the elderly

Urbanová,

Vaníček,

Červená

et al. 2024

Chronobiology International

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Sleep and light education (SLE) combined with relaxation is a potential method of addressing sleep and affective problems in older people. 47 participants took part in a four-week sleep education program. SLE was conducted once a week for 60-90 minutes. Participants were instructed on sleep and light hygiene, sleep processes, and practiced relaxation techniques. Participants were wearing actigraphs for 6 weeks, completed daily sleep diaries, and wore blue light-blocking glasses 120 minutes before bedtime. Measures included scores of the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Insomnia Severity Index (ISS), Beck Depression Inventory-II (BDI-II), State-Trait Anxiety Inventory (STAI) and actigraphy measurements of sleep latency, sleep efficiency, and sleep fragmentation. Sleep quality increased after SLE based on the subjective assessment and in the objective measurement with actigraphy. PSQI scores were statistically reduced indicating better sleep. Scores after the intervention significantly decreased in ESS and ISS. Sleep latency significantly decreased, whereas sleep efficiency and fragmentation index (%), did not improve. Mood significantly improved after SLE, with lower scores on the BDI-II and STAI. SLE combined with relaxation proved to be an effective method to reduce sleep problems and the incidence of depressive and anxiety symptoms.

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Neurological symptoms associated with COVID-19 based on a nation-wide online survey

Cited by 2 publications

References 0 publications

Effects of human probiotics on memory and psychological and physical measures in community-dwelling older adults with normal and mildly impaired cognition: results of a bi-center, double-blind, randomized, and placebo-controlled clinical trial (CleverAge biota)

Effects of human probiotics on memory and psychological and physical measures in community-dwelling older adults with normal and mildly impaired cognition: results of a bi-center, double-blind, randomized, and placebo-controlled clinical trial (CleverAge biota)

The impact of sleep education, light intervention and relaxation on sleep and mood in the elderly

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