Neurological soft signs in bipolar I disorder patients

Negash, Assegid; Kebede, Derege; Alem, Atalay; Melaku, Zenebe; Deyessa, Negussie; Shibire, Teshome; Fekadu, Abebaw; Fekadu, Daniel; Jacobsson, Lars; Kullgren, Gunnar

doi:10.1016/s0165-0327(03)00116-2

Cited by 78 publications

(52 citation statements)

References 40 publications

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“…Associations between sensory system abnormalities and case-level depressive symptoms were found in our study, similar to the findings by Negash et al (2004) for bipolar I disorder. Our finding of cranial nerve abnormalities associated with case-level depressive symptoms has, to our knowledge, not been identified before.…”

Section: Secondary Analysessupporting

confidence: 91%

Neurological signs and late‐life depressive symptoms in a community population: the ESPRIT study

Soremekun

Stewart

Portet

et al. 2010

Int J Geriat Psychiatry

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Section: Secondary Analysessupporting

confidence: 91%

Neurological signs and late‐life depressive symptoms in a community population: the ESPRIT study

Soremekun

Stewart

Portet

et al. 2010

Int J Geriat Psychiatry

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“…As noted above these neurological soft signs may not be specific to schizophrenia but also are found in other neuropsychiatric disorders such as ADHD [62][63][64], and major depression [65], bipolar disorders [66,67]; therefore, the database may be applicable and extended to a wider range of clinical cases with greater public health impact. The lifespan database may facilitate us to calculate the specificity of neurological soft signs in different stages of onset of a specific neuropsychiatric disorder or the corresponding specificity of neurological soft signs in different clinical neuropsychiatric disorders.…”

Section: Illustration Of Neurological Soft Signs As An Example From Cmentioning

confidence: 99%

Consortium for the Human Information and Neurocognitive Endophenotype (CHINE) in mainland China: An example from neurological soft signs for neuropsychiatric disorders

Chan

2011

Chin. Sci. Bull.

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Increasing efforts to identify alternate expressions of neuropsychiatric disorders that are broader than the DSM or ICD diagnostic criteria needed to diagnose them reflects a growing consensus that multidimensional expressions of neuropsychiatric disorders may advance the search for underlying etiological or modulatory factors. Endophenotypic research can be considered to be one of the most promising strategies to bridge the gap between genomic complexity and the phenotypic heterogeneity observed in neuropsychiatric disorders. However, the majority of endophenotype studies were limited to our western counterparts, very little has been done and initiated by scholars in mainland China. In this paper, we urge the need to establish a potential central consortium for endophenotypes to study neuropsychiatric disorders in mainland China. In particular, we illustrate a potential example of neurological soft signs in following the steps for building the consortium. endophenotypes, neurological soft signs, neuropsychiatric disorders, mental health, China Citation:Chan R C K. Consortium for the Human Information and Neurocognitive Endophenotype (CHINE) in mainland China: An example from neurological soft signs for neuropsychiatric disorders.This strategic paper argues the need for establishing a central consortium for the endophenotype approach for neuropsychiatric disorders in mainland China. We start with a brief introduction to endophenotypes, what is known about the concept of endophenotypes, and then to illustrate the claim that endophenotypes are more important than traditional genetic approach of studying neuropsychiatric disorders. This is not our intention to provide a comprehensive review of all endophenotypes employed in neuropsychiatric disorders in this strategic paper because there are several systematic reviews on this aspect [1][2][3][4]. However, we would illustrate an example of a promising endophenotype, neurological soft signs, in detailing the steps for building the consortium.

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“…Even fewer studies appear to have examined motor control in individuals with bipolar disorder. Qualitative studies have observed dysdiadochokinesis in individuals with bipolar disorders compared to healthy control participants, but this finding has been related to impairments in attentional set shifting resulting from dorsolateral prefrontal cortex dysfunction (151,152).…”

Section: Mood and Bipolar Disordermentioning

confidence: 99%

The cerebellum and motor dysfunction in neuropsychiatric disorders

Gowen

Miall

2007

MCER

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The cerebellum is densely interconnected with sensory-motor areas of the cerebral cortex, and in man, the great expansion of the association areas of cerebral cortex is also paralleled by an expansion of the lateral cerebellar hemispheres. It is therefore likely that these circuits contribute to non-motor cognitive functions, but this is still a controversial issue. One approach is to examine evidence from neuropsychiatric disorders of cerebellar involvement. In this review, we narrow this search to test whether there is evidence of motor dysfunction associated with neuropsychiatric disorders consistent with disruption of cerebellar motor function. While we do find such evidence, especially in autism, schizophrenia and dyslexia, we caution that the restricted set of motor symptoms does not suggest global cerebellar dysfunction. Moreover, these symptoms may also reflect involvement of other, extra-cerebellar circuits and detailed examination of specific sub groups of individuals within each disorder may help to relate such motor symptoms to cerebellar morphology.

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Neurological soft signs in bipolar I disorder patients

Cited by 78 publications

References 40 publications

Neurological signs and late‐life depressive symptoms in a community population: the ESPRIT study

Neurological signs and late‐life depressive symptoms in a community population: the ESPRIT study

Consortium for the Human Information and Neurocognitive Endophenotype (CHINE) in mainland China: An example from neurological soft signs for neuropsychiatric disorders

The cerebellum and motor dysfunction in neuropsychiatric disorders

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