Neurological sequelae following Dilantin® overdose in a patient and in experimental animals

Kokenge, Roy; Kutt, Henn; McDowell, Fletcher

doi:10.1212/wnl.15.9.823

Cited by 146 publications

(38 citation statements)

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“…Clinically, some common symptoms and signs of phenytoin toxicity may be attributable to brainstem dysfunction, i.e., vertigo, nystagmus, and diplopia. These effects on the brainstem may be related to the enhanced concentration of phenytoin in this region (Kokenge et al, 1965).…”

Section: Discussionmentioning

confidence: 98%

Comparison of Phenytoin and Phenobarbital Effects on Far‐Field Auditory and Somatosensory Evoked Potential Interpeak Latencies

1982

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Far-field somatosensory and auditory evoked potential (EP) interpeak latencies were measured in normal controls, epileptics not receiving medications, and epileptics receiving phenytoin, phenobarbital, or both. Phenytoin, but no phenobarbital, was associated with a prolongation of EP interpeak latencies at serum level concentrations over 20 micrograms/ml. Neither carbamazepine nor primidone in smaller series were associated with prolongation of EP interpeak latencies.

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Section: Discussionmentioning

confidence: 98%

Comparison of Phenytoin and Phenobarbital Effects on Far‐Field Auditory and Somatosensory Evoked Potential Interpeak Latencies

1982

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“…Cats were used since they show side effects similar to those in humans, i.e., gingival hyperplasia (Hassell and Cooper, 1980) and cerebellar ataxia (Kokenge et al, 1965).…”

mentioning

confidence: 99%

The Effects of Phenytoin on Serum and Organ Concentrations of Zinc and Copper in Cat

et al. 1985

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The effects of phenytoin (PHT) on zinc (Zn) and copper (Cu) concentrations in serum and different organs have been studied in cats. Five cats were treated with PHT 5 mg/kg body weight each day. Increased serum concentrations of Zn and Cu were found after 12 weeks of treatment. Increased Zn concentrations were found in the kidney and increased Cu concentrations in the liver and kidney. There wee signs of fatty degeneration of the liver. It is postulated that the drug acts as a chelator of the minerals and enhances their absorption from the intestine. A Cu accumulation may occur during PHT treatment.

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“…Although cerebellar degeneration has been reported in patients receiving large amounts of diphenylhydantoin (Utterback, 1958;Hofmann, 1958;Kokenge et al, 1965;Selhorst et al, 1972), we think it most unlikely that this is the cause of the cerebellar atrophy in our patient because of the marked asymmetry causing a significant shift to the left of the fourth ventricle.…”

Section: Discussionmentioning

confidence: 63%

Neurological complications of progressive facial hemiatrophy

Wolf

Verity

1974

Journal of Neurology, Neurosurgery & Psychiatry

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Neurological sequelae following Dilantin® overdose in a patient and in experimental animals

Cited by 146 publications

References 0 publications

Comparison of Phenytoin and Phenobarbital Effects on Far‐Field Auditory and Somatosensory Evoked Potential Interpeak Latencies

Comparison of Phenytoin and Phenobarbital Effects on Far‐Field Auditory and Somatosensory Evoked Potential Interpeak Latencies

The Effects of Phenytoin on Serum and Organ Concentrations of Zinc and Copper in Cat

Neurological complications of progressive facial hemiatrophy

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