Neurological Recovery Across a 12-cm-Long Ulnar Nerve Gap Repaired 3.25 Years Post Trauma

Kuffler, Damién P.; Reyes, Onix; Sosa, Iván J.; Santiago-Figueroa, José

doi:10.1227/neu.0b013e31822a9fd2

Cited by 44 publications

(31 citation statements)

References 52 publications

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“…For patients suffering from pain associated with rotator cuff injury, PRP injections lead to a progressive reduction in pain and disability compared to dry needling [178]. The application of PRP to the refreshed end of peripheral nerves evoking neuropathic pain, including excruciating pain, results in the reduction/elimination of that pain [11,[179][180][181].…”

Section: Clinical: Improvementmentioning

confidence: 99%

“…Clinically bridging peripheral nerve gaps with a collagen tube filled with autologous PRP induces axon regeneration across nerve gaps up to 16 cm in length, despite nerves being repaired up to 3.25 years postnerve trauma and in patients up to 58 years of age [181,239,240]. Thus, PRP can induce axon regeneration under conditions where the clinical Bgold standard,^peripheral nerve grafts, is ineffective [181,240].…”

Section: Clinical: Improvementmentioning

confidence: 99%

“…Thus, PRP can induce axon regeneration under conditions where the clinical Bgold standard,^peripheral nerve grafts, is ineffective [181,240]. However, filling collagen tubes with PRP induces axons to regenerate across nerve gaps up to 20 cm in length, when the nerve repair is performed up to 3 years posttrauma and in a patient up to 58 years of age [241].…”

Section: Clinical: Improvementmentioning

confidence: 99%

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Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction

Kuffler

2015

Mol Neurobiol

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Platelet-rich plasma (PRP) has been tested in vitro, in animal models, and clinically for its efficacy in enhancing the rate of wound healing, reducing pain associated with injuries, and promoting axon regeneration. Although extensive data indicate that PRP-released factors induce these effects, the claims are often weakened because many studies were not rigorous or controlled, the data were limited, and other studies yielded contrary results. Critical to assessing whether PRP is effective are the large number of variables in these studies, including the method of PRP preparation, which influences the composition of PRP; type of application; type of wounds; target tissues; and diverse animal models and clinical studies. All these variables raise the question of whether one can anticipate consistent influences and raise the possibility that most of the results are correct under the circumstances where PRP was tested. This review examines evidence on the potential influences of PRP and whether PRP-released factors could induce the reported influences and concludes that the preponderance of evidence suggests that PRP has the capacity to induce all the claimed influences, although this position cannot be definitively argued. Well-defined and rigorously controlled studies of the potential influences of PRP are required in which PRP is isolated and applied using consistent techniques, protocols, and models. Finally, it is concluded that, because of the purported benefits of PRP administration and the lack of adverse events, further animal and clinical studies should be performed to explore the potential influences of PRP.

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Section: Clinical: Improvementmentioning

confidence: 99%

Section: Clinical: Improvementmentioning

confidence: 99%

Section: Clinical: Improvementmentioning

confidence: 99%

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Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction

Kuffler

2015

Mol Neurobiol

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“…Regarding AGC improvement strategies, some approaches include incorporation of extracellular matrix proteins and/or neurotrophic factors. 3,4,22,45 Another, more recent approach has been to incorporate autologous, cultured Schwann cells into the AGCs (Fig. 5).…”

Section: Discussionmentioning

confidence: 99%

Challenges in sciatic nerve repair: anatomical considerations

Burks¹,

Levi²,

Hayes³

et al. 2014

JNS

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“…2,3,18,44 This approach to incorporate bioactive components into the lumen of AGCs has been shown to be especially beneficial when conduits have been used to bridge long nerve gaps in animals. 4,37,43 The addition of autologous Schwann cells within a collagen tube can significantly improve long-distance regeneration in the rat but is not as effective as a reversed nerve autograft.…”

Section: Discussionmentioning

confidence: 99%