Neurological Principles and Rehabilitation of Action Disorders

Pomeroy, Valerie M.; Aglioti, Salvatore Maria; Mark, Victor W.; McFarland, Dennis J.; Stinear, Cathy M.; Wolf, Steven L.; Corbetta, Maurizio; Fitzpatrick, Susan M.

doi:10.1177/1545968311410942

Cited by 107 publications

(99 citation statements)

References 19 publications

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“…666,728,729,[731][732][733] A variety of interventions have been the focus of ≥1 studies but have not yet been shown to be consistently beneficial for upper limb motor rehabilitation. These include somatosensory stimulation [734][735][736][737][738] and noninvasive brain stimulation (transcranial magnetic stimulation or tDCS) in combination with upper extremity exercise therapy, [739][740][741][742][743][744][745][746] interventions targeting motor apraxia, 458 and manual therapy approaches such as stretching, passive exercise, and mobilization, 748 although these approaches are a routine part of practice for individuals with more severely affected upper extremities to prevent contractures and to manage spasticity.…”

Section: Iib Bmentioning

confidence: 99%

Guidelines for Adult Stroke Rehabilitation and Recovery

Winstein¹,

Stein²,

Arena

et al. 2016

Stroke

2,046

840

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e98Purpose-The aim of this guideline is to provide a synopsis of best clinical practices in the rehabilitative care of adults recovering from stroke. Methods-Writing group members were nominated by the committee chair on the basis of their previous work in relevant topic areas and were approved by the American Heart Association (AHA) Stroke Council's Scientific Statement Oversight Committee and the AHA's Manuscript Oversight Committee. The panel reviewed relevant articles on adults using computerized searches of the medical literature through 2014. The evidence is organized within the context of the AHA framework and is classified according to the joint AHA/American College of Cardiology and supplementary AHA methods of classifying the level of certainty and the class and level of evidence. The document underwent extensive AHA internal and external peer review, Stroke Council Leadership review, and Scientific Statements Oversight Committee review before consideration and approval by the AHA Science Advisory and Coordinating Committee. Results-Stroke rehabilitation requires a sustained and coordinated effort from a large team, including the patient and his or her goals, family and friends, other caregivers (eg, personal care attendants), physicians, nurses, physical and occupational therapists, speech-language pathologists, recreation therapists, psychologists, nutritionists, social workers, and others. Communication and coordination among these team members are paramount in maximizing the effectiveness

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Section: Iib Bmentioning

confidence: 99%

Guidelines for Adult Stroke Rehabilitation and Recovery

Winstein¹,

Stein²,

Arena

et al. 2016

Stroke

2,046

840

View full text Add to dashboard Cite

show abstract

“…The current data suggest that resolving edema and resolution/ attenuation of inflammatory responses drive the normalization of perilesional T 2 values in L-655,708-treated animals. 38 In addition to the progressive reduction in necrotic core and perilesional tissue volume, L-655,708 treatment elicited skilled reaching ability improvement. Importantly, sensorimotor improvement on the Montoya staircase test is rare because of the specificity and difficulty of the task, underscoring the significance of the present observation of recovery to~62% of baseline reaching ability after 2 weeks of treatment.…”

Section: ) (A)mentioning

confidence: 99%

The Effects of Delayed Reduction of Tonic Inhibition on Ischemic Lesion and Sensorimotor Function

Lake

Chaudhuri

Thomason

et al. 2015

J Cereb Blood Flow Metab

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To aid in development of chronic stage treatments for sensorimotor deficits induced by ischemic stroke, we investigated the effects of GABA antagonism on brain structure and fine skilled reaching in a rat model of focal ischemia induced via cortical microinjections of endothelin-1 (ET-1). Beginning 7 days after stroke, animals were administered a gamma-aminobutyric acid (GABA A ) inverse agonist, L-655,708, at a dose low enough to afford α5-GABA A receptor specificity. A week after stroke, the ischemic lesion comprised a small hypointense necrotic core (6 ± 1 mm 3 ) surrounded by a large (62 ± 11 mm 3 ) hyperintense perilesional region; the skilled reaching ability on the Montoya staircase test was decreased to 34% ± 2% of the animals' prestroke performance level. On L-655,708 treatment, animals showed a progressive decrease in total stroke volume (13 ± 4 mm 3 per week), with no change in animals receiving placebo. Concomitantly, treated animals' skilled reaching progressively improved by 9% ± 1% per week, so that after 2 weeks of treatment, these animals performed at 65% ± 6% of their baseline ability, which was 25% ± 11% better than animals given placebo. These data indicate beneficial effects of delayed, sustained low-dose GABA A antagonism on neuroanatomic injury and skilled reaching in the chronic stage of stroke recovery in an ET-1 rat model of focal ischemia.

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“…4,5 The rationale was that AO primed brain regions involved in movement production, enhancing the benefits of subsequent movement practice. 6 Results in stroke were encouraging, 4,7,8 but few studies have assessed AO therapy in children with CP. Buccino et al 9 undertook a pilot study of 15 children aged 6 to 11 years with hemiplegia or tetraplegia.…”

mentioning

confidence: 99%

Effect of parent‐delivered action observation therapy on upper limb function in unilateral cerebral palsy: a randomized controlled trial

Kirkpatrick

Pearse

James

et al. 2016

Develop Med Child Neuro

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Aim To determine whether home‐based, parent‐delivered therapy comprising action observation (AO) and repeated practice (RP) improves upper limb function more than RP alone in children with unilateral cerebral palsy (UCP). Method Design: single‐blinded parallel‐group randomized controlled trial with 1:1 allocation comparing AO+RP (intervention) with RP alone (control). Randomization: computer‐generated, with allocation concealment by opaque sequentially‐numbered envelopes. Setting: northern England, August 2011 to September 2013. Participants: 70 children with UCP; mean age 5.6 years (SD 2.1), 31 female. Intervention: home‐based activities were provided, tailored to interests and abilities. Duration: 15 minutes/day, 5 days/week for 3 months. Assessments: Assisting Hand Assessment (AHA; primary outcome measure), Melbourne Assessment 2 (MA2), and ABILHAND‐Kids at baseline, 3 months, and 6 months. Results Outcome data was available at 3 months for 28 children in the AO+RP group and 31 controls, and at 6 months for 26 and 28 children respectively. There were no between‐group differences in AHA, MA2, or ABILHAND‐Kids at 3 or 6 months versus baseline (all p>0.05). Combined‐group improvements (p<0.001), observed in AHA and MA2 at 3 months, were maintained at 6 months. ABILHAND‐Kids also showed improvement at 3 months (p=0.003), maintained at 6 months. Interpretation Parent‐delivered RP (with or without AO) improves upper limb function and could supplement therapist input.

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Neurological Principles and Rehabilitation of Action Disorders

Cited by 107 publications

References 19 publications

Guidelines for Adult Stroke Rehabilitation and Recovery

Guidelines for Adult Stroke Rehabilitation and Recovery

The Effects of Delayed Reduction of Tonic Inhibition on Ischemic Lesion and Sensorimotor Function

Effect of parent‐delivered action observation therapy on upper limb function in unilateral cerebral palsy: a randomized controlled trial

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