Neurological presentations of Bartonella henselae infection

Canneti, Beatrice; Cabo, Iria; Puy-Núñez, Alfredo; García, Juan Carlos García; Cores, F.J.; Trigo, Matilde; Suarez-Gil, Ana Paula; Rodríguez-Regal, Ana

doi:10.1007/s10072-018-3618-5

Cited by 39 publications

(40 citation statements)

References 45 publications

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“…Bartonella henselae is a gram-negative bacillus that causes cat-scratch disease after transmission from asymptomatic bacteremic cats. Approximately 1 to 10% of patients with catscratch disease develop neurologic manifestations, primarily lymphocytic meningoencephalitis 27 and neuroretinitis characterized by the sudden onset of unilateral loss of vision and stellate macular exudates on fundoscopy. 16 Infection in HIV patients can on occasion lead to neuropsychiatric disorders.…”

Section: Bacteria Generally Diagnosed By Serologymentioning

confidence: 99%

Diagnostic Testing in Central Nervous System Infection

2019

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Several key points should guide providers managing a patient with suspected CNS infection. The first is the importance of developing a plan for the diagnostic workup. Clinicians are recommended to first test for the most likely and Keywords ► meningitis ► encephalitis ► diagnostic ► metagenomic sequencing AbstractPatients with central nervous system (CNS) infection experience very high levels of morbidity and mortality, in part because of the many challenges inherent to the diagnosis of CNS infection and identification of a causative pathogen. The clinical presentation of CNS infection is nonspecific, so clinicians must often order and interpret many diagnostic tests in parallel. This can be a daunting task given the large number of potential pathogens and the availability of different testing modalities. Here, we review traditional diagnostic techniques including Gram stain and culture, serology, and polymerase chain reaction (PCR). We highlight which of these are recommended for the pathogens most commonly tested among U.S. patients with suspected CNS infection. Finally, we describe the newer broadrange diagnostic approaches, multiplex PCR and metagenomic sequencing, which are increasingly used in clinical practice.This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.• What pathogen is being interrogated;• How to test for it (e.g., serology vs. PCR);• Where to look (e.g., CSF vs. blood);• When to test (e.g., need for paired acute/convalescent sera).Another important consideration is the turnaround time between ordering a test and receiving its results, since clinical decisions often need to be made empirically while awaiting test results. In general, PCR tests are rapid and often available in-house, while specialized serology tests may only be available at reference laboratories. However, there is substantial variation between clinical microbiology laboratories, so close communication with laboratory personnel is essential. Detection of Immune Response by SerologySerological tests are widely used in the diagnosis of CNS infections, particularly for pathogens present at low levels or for brief periods of time, and for diseases whose manifestations are primarily mediated by the host antibody response.

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Section: Bacteria Generally Diagnosed By Serologymentioning

confidence: 99%

Diagnostic Testing in Central Nervous System Infection

2019

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“…One complication of CSD is Parinaud oculoglandular syndrome, which presents with fever, regional lymphadenopathy, and granulomatous follicular conjunctivitis. Other complications include neuroretinitis, focal retinochoroiditis, iridocyclitis, papillitis, peripapillary angiomatosis, serous retinal detachment, branch retinal arteriolar occlusion, endophthalmitis, myelitis, aseptic meningitis, and encephalitis 8,9 . B. henselae is also one of the etiologic agents of bacillary angiomatosis (the other being B. quintana, a humanspecific pathogen with worldwide distribution transmitted by the human body louse Pediculus humanus humanus).…”

Section: Discussionmentioning

confidence: 99%

A case of Bartonella neuroretinitis with macular star diagnosed by clinical, epidemiological, serological, and molecular data: resolution after initiation of antimicrobial therapy

Eyer-Silva

Wutke

Paiva

et al. 2020

Rev. Soc. Bras. Med. Trop.

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The differential diagnosis of optic neuritis is broad and varied. We report the case of a 24-year-old Brazilian man who presented with five-week history of fever, malaise, myalgia, severe fatigue, tender right preauricular lymphadenopathy, and acute vision blurring associated with right optic disc swelling and exudates in a macular star pattern. His illness developed soon after an infestation of fleas broke out among his cats. Diagnosis of ocular bartonellosis was confirmed by serological and molecular analyses targeting amplification of Bartonella spp. htrA gene. Signs and symptoms only improved after initiation of antimicrobial therapy.

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“…Cat-scratch disease usually develops in immunocompetent humans and more commonly affects children and teenagers (Amer, Tugal-Tutkun, 2017). The symptoms include erythematous papule at the site of inoculation, swelling of lymph nodes, fever, aching, malaise, or anorexia (Canneti et al, 2019;Hobson et al, 2017;Klotz et al, 2011). Other less common symptoms may include myalgia, arthralgia, and hepatosplenomegaly (Johnson, 2020).…”

Section: Clinical Manifestations Of Cat-associated Bartonella Infection and Treatmentmentioning

confidence: 99%

Bartonella spp. in cats

Drigotaitė¹,

Razgūnaitė²,

Radzijevskaja³

et al. 2021

biologija

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Bartonella spp. are gram-negative, haemotropic bacteria infecting both a wide range of animals and humans. The currently known vectors of Bartonella spp. are fleas, ticks, lice, and sand flies. Domestic cats are the main reservoir for B. henselae, B. clarridgeiae, and B. koehlerae. Bartonella infections in cats vary from mild to deadly and, since they usually have no specific symptoms, they are often underestimated. This review provides information on Bartonella infections in cats, their biology, and pathogenicity.

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Neurological presentations of Bartonella henselae infection

Cited by 39 publications

References 45 publications

Diagnostic Testing in Central Nervous System Infection

Diagnostic Testing in Central Nervous System Infection

A case of Bartonella neuroretinitis with macular star diagnosed by clinical, epidemiological, serological, and molecular data: resolution after initiation of antimicrobial therapy

Bartonella spp. in cats

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