Neurological paraneoplastic syndromes in patients with small cell lung cancer. A prospective survey of 150 patients.

Elrington, Giles; Murray, N.M.F.; Spiro, S. G.; Newsom‐Davis, John

doi:10.1136/jnnp.54.9.764

Cited by 175 publications

(70 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other tumors include small cell carcinomas of the prostate and cervix, lymphomas, and adenocarcinomas. The prevalence of LEMS in patients with SCLC is estimated to be around 3% [87,89]. Clinically and serologically, the 30% without identifiable tumors are indistinguishable from the paraneoplastic LEMS patients, although LEMS may have a more progressive course in patients with SCLC [85].…”

Section: Underlying Tumormentioning

confidence: 99%

“…Deep tendon reflexes, especially those in the legs, are diminished or absent but may reappear after exercise. Autonomic features, especially dryness of the mouth, impotence, and mild/moderate ptosis, ultimately develop in 95% of patients [85][86][87]. In some patients, LEMS may develop in association with other PNS, including PCD and encephalomyelitis [50].…”

Section: Lemsmentioning

confidence: 99%

See 1 more Smart Citation

Managing Paraneoplastic Neurological Disorders

2006

View full text Add to dashboard Cite

show abstract

Section: Underlying Tumormentioning

confidence: 99%

Section: Lemsmentioning

confidence: 99%

Managing Paraneoplastic Neurological Disorders

2006

View full text Add to dashboard Cite

show abstract

“…This fact may be due to the lack of diagnosis or to rare occurrence of this disease in our country compared with other locations. Studies report that 3% of patients with oat cell lung carcinoma develop Lambert-Eaton syndrome 39 , even though we do not have such associated cases registered in our service. This fact reinforces the theory that there is a lack of diagnosis.…”

Section: Discussionmentioning

confidence: 97%

Lambert-Eaton myasthenic syndrome: Report of two cases

Werneck¹

1997

Electroencephalography and Clinical Neurophysiology

View full text Add to dashboard Cite

-Two cases of Lambert-Eaton myasthenic syndrome, in female patients whose neoplasm investigation was negative, are reported. Repetitive stimulation of ulnar nerve showed an incremental response (+187% and +198%). Needle EMG was normal in one of them, however, the other patient showed fibrillation potentials, positive sharp waves, potentials of low amplitude and short duration. The authors discuss the clinical, electrophysiological, and pathological features of the disease, as well as some aspects of the treatment and follow-up of these patients.KEY WORDS: Lambert-Eaton myasthenic syndrome, neurophysiological study, muscular biopsy, treatment. Síndrome miastênica de Lambert-Eaton: relato de dois casosRESUMO -São descritos dois casos de síndrome miastênica de Lambert-Eaton em pacientes do sexo feminino, nas quais a investigação de neoplasias foi negativa. Os testes de estimulação repetitiva mostraram incrementos de 187 e 198%. A eletromiografia de agulha em um dos casos foi normal e no outro mostrou potenciais de fibrilação, ondas agudas positivas de curta duração e baixa amplitude de potenciais. São discutidos aspectos clínicos, neurofisiológicos, biópsia muscular, tratamento e acompanhamento desta condição rara. PALAVRAS-CHAVE: síndrome miastênica de Lambert-Eaton, estudo neurofisiológico, biópsia muscular, tratamento.Lambert-Eaton myasthenic syndrome is a rare condition, resulting from an acetylcholine release deficiency in the neuromuscular junction. Over 50% of the cases are related with oat cell lung carcinoma [1][2][3] . Lambert-Eaton syndrome has also been associated with squamous cell lung carcinoma, mixed tumors of the parotid glands, systemic mastocytosis, sarcomas, kidney carcinoma and other malignant neoplastic diseases [3][4][5] . As Lambert-Eaton syndrome presents mostly as a paraneoplastic condition, an extensive investigation of malignant tumors should be performed. However, approximately 40% of the patients do not show any evidence of cancer, and in these cases, the disease is considered to be of primary autoimmune origin 1,2 .We report two cases of Lambert-Eaton myasthenic syndrome in female patients whose investigation for neoplastic diseases was negative, and due to the rarity of this type of disease, we found it worth putting on record.

show abstract

“…Although PNSs are rare and occur in fewer than 1% of cancer patients overall, up to 3%-5% of patients with SCLC develop PNSs [95,97] . The irreversible destruction of neurons and nervous systems by the inflammation con- Table 4 Classical and non-classical paraneoplastic neurological syndromes [93] Syndromes of the central nervous system Encephalomyelitis Kanaji N et al .…”

Section: Syndromesmentioning

confidence: 99%

Paraneoplastic syndromes associated with lung cancer

1993

Lung Cancer

View full text Add to dashboard Cite

Paraneoplastic syndromes are signs or symptoms that occur as a result of organ or tissue damage at locations remote from the site of the primary tumor or metastases. Paraneoplastic syndromes associated with lung cancer can impair various organ functions and include neurologic, endocrine, dermatologic, rheumatologic, hematologic, and ophthalmological syndromes, as well as glomerulopathy and coagulopathy (Trousseau's syndrome). The histological type of lung cancer is generally dependent on the associated syndrome, the two most common of which are humoral hypercalcemia of malignancy in squamous cell carcinoma and the syndrome of inappropriate antidiuretic hormone secretion in small cell lung cancer. The symptoms often precede the diagnosis of the associated lung cancer, especially when the symptoms are neurologic or dermatologic. The proposed mechanisms of paraneoplastic processes include the aberrant release of humoral mediators, such as hormones and hormone-like peptides, cytokines, and antibodies. Treating the underlying cancer is generally the most effective therapy for paraneoplastic syndromes, and treatment soon after symptom onset appears to offer the best potential for symptom improvement. In this article, we review the diagnosis, potential mechanisms, and treatments of a wide variety of paraneoplastic syndromes associated with lung cancer.

show abstract

Neurological paraneoplastic syndromes in patients with small cell lung cancer. A prospective survey of 150 patients.

Abstract: One hundred and fifty patients presenting with small cell lung cancer (SCLC)

Cited by 175 publications

References 17 publications

Managing Paraneoplastic Neurological Disorders

Managing Paraneoplastic Neurological Disorders

Lambert-Eaton myasthenic syndrome: Report of two cases

Paraneoplastic syndromes associated with lung cancer

Contact Info

Product

Resources

About