Neurological outcome at 24 months corrected age of prematurely born infants after preterm premature rupture of membranes (PPROM) of at least 7 days: a two-center experience in Germany

Müller, Hanna; Storbeck, Tobias; Katzer, David; Bruns, Nora; Wössner-Stegmann, Gaby; Ai, Maria; Köninger, Angela; Müller, Andreas; Felderhoff-Müser, Ursula; Bağcı, Soyhan

doi:10.1080/14767058.2018.1517327

Cited by 4 publications

(5 citation statements)

References 17 publications

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“…Approximately 30% of preterm births are preceded by preterm prelabor rupture of membranes (pPROM) [4][5][6][7][8][9][10][11][12], defined as the rupture of the chorioamniotic membranes before the onset of preterm labor (i.e. <37 weeks) [4,[6][7][8][9][10][11][12]; thus, this clinical condition is a major contributor to maternal and neonatal morbidity [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. pPROM is considered a great obstetrical syndrome [32][33][34][35][36] and has recently been subcategorized using microbiological techniques coupled with amniotic fluid concentrations of interleukin-6 (IL-6) [37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes

Galaz

Romero

Slutsky

et al. 2020

Journal of Perinatal Medicine

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Background Preterm birth is the leading cause of perinatal morbidity and mortality. Preterm prelabor rupture of membranes (pPROM) occurs in 30% of preterm births; thus, this complication is a major contributor to maternal and neonatal morbidity. However, the cellular immune responses in amniotic fluid of women with pPROM have not been investigated. Methods Amniotic fluid samples were obtained from women with pPROM and a positive (n = 7) or negative (n = 10) microbiological culture. Flow cytometry was performed to evaluate the phenotype and number of amniotic fluid leukocytes. The correlation between amniotic fluid immune cells and an interleukin-6 (IL-6) concentration or a white blood cell (WBC) count in amniotic fluid was calculated. Results Women with pPROM and a positive amniotic fluid culture had (1) a greater number of total leukocytes in amniotic fluid, including neutrophils and monocytes/macrophages and (2) an increased number of total T cells in amniotic fluid, namely CD4+ T cells and CD8+ T cells, but not B cells. The numbers of neutrophils and monocytes/macrophages were positively correlated with IL-6 concentrations and WBC counts in amniotic fluid of women with pPROM. Conclusion Women with pPROM and a positive amniotic fluid culture exhibit a more severe cellular immune response than those with a negative culture, which is associated with well-known markers of intra-amniotic inflammation.

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Section: Introductionmentioning

confidence: 99%

Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes

Galaz

Romero

Slutsky

et al. 2020

Journal of Perinatal Medicine

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“…This was confirmed by another study concluding that for a given gestational age at birth, prolonged latency duration after PPROM does not worsen neonatal prognosis [ 24 ]. A further study of the University Hospitals Bonn and Essen, Germany, showed that PPROM ≥ 7 days did not influence neurodevelopmental outcome at a corrected age of 24 months [ 25 ]. In contrast to these results, Patkai et al observed in a small cohort of very immature preterm infants with PPROM < 25 weeks a higher rate of delayed acquisitions (64.3% versus 15.8%), of behavioral disorders (57.1% versus 15.8%) and of lower language performance in two year old toddlers in comparison to children without PPROM (PPROM duration (mean ± SD) 16.6 ± 16.0 days).…”

Section: Discussionmentioning

confidence: 99%

Latency duration of preterm premature rupture of membranes and neonatal outcome: a retrospective single-center experience

et al. 2021

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In preterm premature rupture of membranes (PPROM), a decision between early delivery with prematurity complications and pregnancy prolongation bearing the risk of chorioamnionitis has to be made. To define disadvantages of delayed prolongation, latency duration of PPROM in expectantly managed pregnancies was investigated. We included those PPROMs > 48 h leading to preterm birth prior 37 weeks’ gestation and retrospectively analyzed 84 preterm infants fulfilling these criteria. The association between latency duration/appearance of PPROM and respiratory outcome (primary outcomes) and neurological outcome (secondary outcomes) was investigated. The study showed that latency duration of PPROM is not associated with clinical or histological chorioamnionitis (p = 0.275; p = 0.332). As the numerous clinical parameters show multicollinearity between each other, we performed a multiple regression analysis to consider this fact. Respiratory distress syndrome is significantly associated with gestational age at PPROM (p < 0.001), and surfactant application is significantly associated with PPROM duration (p = 0.014). The other respiratory parameters including steroids and diuretics therapy, bronchopulmonary dysplasia, and the neurological parameters (intraventricular hemorrhage, Bayley II testing at a corrected age of 24 months) were not significantly associated with PPROM duration or gestational age at PPROM diagnosis.Conclusion: Latency duration of PPROM was not associated with adverse neonatal outcome in expectantly and carefully managed pregnancies, but respiratory distress syndrome was pronounced. The observed effect of pronounced respiratory distress syndrome can be treated with surfactant preparations and was not followed by increased rate of bronchopulmonary dysplasia. What is Known:• In case of preterm premature rupture of membranes, a decision between pregnancy prolongation with the risk of chorioamnionitis and early delivery with prematurity complications has to be made.• Chorioamnionitis is a dangerous situation for the pregnant woman and the fetus.• Impaired neurodevelopmental outcome is strongly correlated with pronounced prematurity due to the increased rate of serious complications. What is New:• Respiratory distress syndrome is significantly associated with gestational age at PPROM, and surfactant application is significantly associated with PPROM duration.• Latency duration of PPROM is not associated with adverse respiratory neonatal outcome (therapy with continuous positive airway pressure, therapy with diuretics and/or steroids, bronchopulmonary dysplasia) in expectantly and carefully managed pregnancies.• Intraventricular hemorrhage and Bayley II testing at a corrected age of 24 months are not associated with latency duration of PPROM when pregnancies are carefully observed.

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“…In the study of 239 group B. Streptococcus -negative patients with PPROM at 24–32 weeks of gestation, the median continuation of pregnancy was 6.1 days despite prophylactic antibiotic treatment. Overall, 56% of patients gave birth within seven days, 76% within 14 days, and 86% within 21 days [ 15 , 16 , 17 ].…”

Section: Clinical Issuesmentioning

confidence: 99%

“…The study of Wagner et al showed that 50% of children with PPROM at 24 weeks of gestation could be discharged from the hospital without major complications [ 89 ]. Neurodevelopment of children at 24 months after delivery after 7-day PPROM (at 24–31 weeks of gestation) was similar to the development of infants delivered at the same gestational age without PPROM [ 17 ].…”

Section: Clinical Issuesmentioning

confidence: 99%

The Management of Pregnancy Complicated with the Previable Preterm and Preterm Premature Rupture of the Membranes: What about a Limit of Neonatal Viability?—A Review

Feduniw

Gaca²,

Malinowska

et al. 2022

Diagnostics

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Preterm premature rupture of the membranes (PPROM) at the limit of viability is associated with low neonatal survival rates and a high rate of neonatal complications in survivors. It carries a major risk of maternal morbidity and mortality. The limit of viability can be defined as the earliest stage of fetal maturity when a fetus has a reasonable chance, although not a high likelihood, for extra-uterine survival. The study reviews available data on preventing preterm delivery caused by the previable PPROM, pregnancy latency, therapeutic options including the use of antibiotics and steroids, neonatal outcomes, and future directions and opportunities.

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Neurological outcome at 24 months corrected age of prematurely born infants after preterm premature rupture of membranes (PPROM) of at least 7 days: a two-center experience in Germany

Abstract: PPROM of at least 7 days has no influence on neurodevelopmental outcome at a corrected age of 24 months when birth is initiated in the case of beginning CA.

Cited by 4 publications

References 17 publications

Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes

Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes

Latency duration of preterm premature rupture of membranes and neonatal outcome: a retrospective single-center experience

The Management of Pregnancy Complicated with the Previable Preterm and Preterm Premature Rupture of the Membranes: What about a Limit of Neonatal Viability?—A Review

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