Neurological Nuance: Hodgkin lymphoma presenting with Guillain–BarrÉ syndrome

Anderson, Dustin; Beecher, Grayson; Steve, Trevor A.; Jen, Ho; Camicioli, Richard; Zochodne, Douglas W.

doi:10.1002/mus.25439

Cited by 9 publications

(6 citation statements)

References 13 publications

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“…9 Anderson et al describe a case where GBS was diagnosed first, and treatment with intravenous immunoglobulin resulted in worsened neurology that prompted the eventual diagnosis of lymphoma. 10 This is in contrast to our patient who responded well to intravenous immunoglobulin and recovered from GBS without any treatment directed at a potential underlying lymphoma.…”

Section: Differential Diagnosiscontrasting

confidence: 97%

Guillain-Barré syndrome and COVID-19: association or coincidence

2020

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COVID-19 is a novel disease best known to cause a cough, fever and respiratory failure. Recently, it has been recognised that COVID-19 may present in multi-systemic ways which can cause diagnostic uncertainty or error.We present a patient who attended hospital with features of Guillain-Barré syndrome (GBS) before developing clinical and radiological findings of COVID-19. While the authors recognise that neurological complications have been reported following COVID-19 infection, to their knowledge this report describes a unique presentation of GBS without preceding COVID-19 symptoms.Since these conditions may have considerable overlapping features including respiratory failure and (following prolonged critical care admission) profound weakness, it is possible that one diagnosis may be overlooked. Raising awareness of a possible association between these conditions is important so both are considered allowing appropriate investigations to be arranged to optimise the chance of neurological recovery and survival, while also protecting staff from potentially unrecognised COVID-19.

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Section: Differential Diagnosiscontrasting

confidence: 97%

Guillain-Barré syndrome and COVID-19: association or coincidence

2020

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“…Likewise, after their clinical and pathological research on GBS and Hodgkin’s lymphoma, Julien et al [14] reported a case of GBS in a patient with a relapsed phase of Hodgkin’s lymphoma. Both Anderson et al [21] and Cabot et al [16] (the latter from a case at Massachusetts General Hospital in the United States) revealed that GBS immediately preceded Hodgkin’s lymphoma, as in the present case. However, in comparison with the other previously reported cases, in this case, our patient manifested a more severe form of GBS in term of muscle power, and it was more acute to have GBS presentation after the confirmation of Hodgkin’s type lymphoma.…”

Section: Discussionsupporting

confidence: 72%

Guillain-Barré Syndrome Heralding the Diagnosis of Hodgkin Lymphoma: A Case Report

Al-Attas¹,

Aldayel²,

Najjar³

et al. 2020

Case Rep Neurol

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Lymphoma is a prevalent type of lymphoid tissue malignancy that is seldom associated with Guillain-Barré syndrome (GBS). In the majority of instances, both Hodgkin’s and non-Hodgkin’s lymphoma are not proceeded by GBS. Here, we report on a case of a young patient with a manifestation and investigation suggestive of GBS, signaling an unconfirmed diagnosis of Hodgkin’s lymphoma. A cerebrospinal fluid test revealed an albuminocytological dissociation with a noteworthy rise in protein (2.32 g/L). The patient was initiated on intravenous immunoglobulin (IVIG) treatment and then showed dramatic improvement after the third dose of IVIG. His constitutional presentation alongside high inflammatory labs prompted further investigation. An enhanced pan-computed tomography scan showed multiple enlarged mediastinal and hilar lymph nodes that were confirmed as Hodgkin’s lymphoma after biopsy. Brentuximab was initiated immediately after IVIG therapy. This case highlights consideration of Hodgkin’s lymphoma as a differential diagnosis under the auspices of GBS.

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“…According to our research, only a single case-control study described a positive association between GBS and cancer [25]. Guillain-Barré syndrome is mostly associated with lymphomas [26,27]. Solid tumors associated with GBS include small cell lung cancer, breast cancer, renal cancer, hepatocellular carcinoma, tongue carcinoma, esophageal carcinoma, and the ovarian dysgerminoma.…”

Section: Discussionmentioning

confidence: 74%

Anti-GD1b and anti-GM1 positive, acute inflammatory demyelinating polyneuropathy associated with advanced ovarian carcinoma: A case report

Julie¹,

Liapi²,

Hastir³

et al. 2021

Int J Case Rep Images

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Introduction: Paraneoplastic neurological syndromes (PNSs) are mostly associated with non-epithelial ovarian cancers. We report the case of an advanced high-grade serous ovarian adenocarcinoma, diagnosed during the etiological investigation of a subacute motor-sensory axonal neuropathy variant (AMSAN) of Guillain-Barré syndrome (GBS). According to our literature review, only a single case-control study described a positive association between GBS and cancer.Case Report: A 73-year-old woman was admitted to the emergency department for a progressive symmetrical distal tetraparesis, associated with hypoesthesia and abdominal pain. There was no sign of viral or bacterial infection. Over a period of 10 days, she presented a rapid neurological deterioration with nearly complete paralysis of all extremity, facial, and respiratory muscles.

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Neurological Nuance: Hodgkin lymphoma presenting with Guillain–BarrÉ syndrome

Cited by 9 publications

References 13 publications

Guillain-Barré syndrome and COVID-19: association or coincidence

Guillain-Barré syndrome and COVID-19: association or coincidence

Guillain-Barré Syndrome Heralding the Diagnosis of Hodgkin Lymphoma: A Case Report

Anti-GD1b and anti-GM1 positive, acute inflammatory demyelinating polyneuropathy associated with advanced ovarian carcinoma: A case report

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