Neurological monitoring in ECMO patients: current state of practice, challenges and lessons

Abstract

Background Extracorporeal membrane oxygenation (ECMO) in critically ill patients serves as a management option for end-stage cardiorespiratory failure in medical and surgical conditions. Patients on ECMO are at a high risk of neurologic adverse events including intracranial hemorrhage (ICH), acute ischemic stroke (AIS), seizures, diffuse cerebral edema, and hypoxic brain injury. Standard approaches to neurological monitoring for patients receiving ECMO support can be challenging for multiple reasons, including the severity of critical illness, deep sedation, and/or paralysis. This narrative literature review provides an overview of the current landscape for neurological monitoring in this population. Methods A literature search using PubMed was used to aid the understanding of the landscape of published literature in the area of neurological monitoring in ECMO patients. Results Review articles, cohort studies, case series, and individual reports were identified. A total of 73 varied manuscripts were summarized and included in this review which presents the challenges and strategies for performing neurological monitoring in this population. Conclusion Neurological monitoring in ECMO is an area of interest to many clinicians, however, the literature is limited, heterogenous, and lacks consensus on the best monitoring practices. The evidence for optimal neurological monitoring that could impact clinical decisions and functional outcomes is lacking. Additional studies are needed to identify effective measures of neurological monitoring while on ECMO. Supplementary Information The online version contains supplementary material available at 10.1007/s13760-023-02193-2.

A Comprehensive Review of Extra Corporeal Membrane Oxygenation: The Lifeline in Critical Moments

“…Neurological status informs decisions about the appropriateness of ECMO, especially considering the potential risks of neurological complications associated with the therapy. A thorough understanding of the patient's neurological condition aids in tailoring ECMO management strategies to minimize the risk of adverse neurological outcomes [30].…”

“…Neurological monitoring is particularly crucial during ECMO, where the risk of complications such as emboli or hypoperfusion is heightened. The data collected from these assessments inform clinical decision-making, guide adjustments to ECMO settings, and contribute to a proactive approach to managing neurological complications [30].…”

Neuromonitoring of Pediatric and Adult Extracorporeal Membrane Oxygenation Patients: The Importance of Continuous Bedside Tools in Driving Neuroprotective Clinical Care

“…18,97 A comparison of these modalities between neonates, pediatrics, and adults has been described in Table 3. 18,19,98 However, as detailed above, these tools have significant limitations. There are clear opportunities to develop protocolized combinations of existing clinical modalities and hybrid online data analysis schemes.…”