Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases

Weinreb, Orly; Mandel, Silvia; Amit, Tamar; Youdim, Moussa B. H.

doi:10.1016/j.jnutbio.2004.05.002

Cited by 445 publications

(261 citation statements)

References 116 publications

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“…Green tea, one of the world's most widely consumed beverages, contains a number of these biologically active polyphenolic compounds, suggesting that the active components of green tea may be beneficial and neuroprotective in conditions of increased oxidative load. Recent studies have demonstrated the neuroprotective activity of GTP in animal models of neurodegenerative conditions such as Parkinson's and Alzheimer's disease and their ability to markedly reduce hypoxic-ischemic tissue loss in models of ischemic stroke through inhibition of caspase-3 activation and proteolytic cleavage of its substrates (31)(32)(33)(34). Although the potential mechanisms whereby GTP may prevent neurological deficits remain to be fully elucidated, recent evidence suggests that GTP may operate as potent free oxygen radical scavengers and protect the brain and other Relative prostaglandin E 2 (PGE 2 ) production in the hippocampal CA1 region of rats exposed to room air (RA) or intermittent hypoxia (IH) and treated with green tea polyphenols (GTP) or vehicle (n 5 3 per group; *P , 0.05, # P , 0.05 vs. RA).…”

Section: Discussionmentioning

confidence: 99%

Green Tea Catechin Polyphenols Attenuate Behavioral and Oxidative Responses to Intermittent Hypoxia

Burckhardt

Gozal²,

Dayyat³

et al. 2008

Am J Respir Crit Care Med

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Rationale: The intermittent hypoxia (IH) that characterizes sleepdisordered breathing impairs spatial learning and increases NADPH oxidase activity and oxidative stress in rodents. We hypothesized that green tea catechin polyphenols (GTPs) may attenuate IHinduced neurobehavioral deficits by reducing IH-induced NADPH oxidase expression, lipid peroxidation, and inflammation. Objectives: To assess the effects of GTP administered in drinking water on the cognitive, inflammatory, and oxidative responses to long-term (.14 d) IH during sleep in male Sprague-Dawley rats. Methods: Cognitive assessments were conducted in the Morris water maze. We measured levels and expression of malondialdehyde (MDA), prostaglandin E 2 , p47 phox subunit of NADPH oxidase, receptor for advanced glycation end products (RAGE), and glial fibrillary acidic protein expression in rodent brain tissue. Measurements and Main Results: GTP treatment prevented IH-induced decreases in spatial bias for the hidden platform during the Morris water maze probe trails as well as IH-induced increases in p47phox expression within the hippocampal CA1 region. In untreated animals, IH exposure was associated with doubling of cortical MDA levels in comparison to room air control animals, and GTP-treated animals exposed to IH showed a 40% reduction in MDA levels. Increases in brain RAGE and glial fibrillary acidic protein expression were observed in IH-exposed animals, and these increases were attenuated in animals treated with GTP. Conclusions: Oral GTP attenuates IH-induced spatial learning deficits and mitigates IH-induced oxidative stress through multiple beneficial effects on oxidant pathways. Because oxidative processes underlie neurocognitive deficits associated with IH, the potential therapeutic role of GTP in sleep-disordered breathing deserves further exploration.

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Section: Discussionmentioning

confidence: 99%

Green Tea Catechin Polyphenols Attenuate Behavioral and Oxidative Responses to Intermittent Hypoxia

Burckhardt

Gozal²,

Dayyat³

et al. 2008

Am J Respir Crit Care Med

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“…[1][2][3][4] Furthermore, green tea polyphenols (GTPs) have been implicated as neuroprotective agents in diseases such as Alzheimer's and Parkinson's through the reduction of iron accumulation, reactive oxygen species (ROS), and inflammation. 3,6 Being regarded as a functional food and broad-spectrum botanical, green tea appears to impact various biological processes that may contribute to a reduction in the rates of aging and age-associated diseases. 3,6 Previous reports have found green tea to extend the lifespan of various animal models.…”

Section: Introductionmentioning

confidence: 99%

“…3,6 Being regarded as a functional food and broad-spectrum botanical, green tea appears to impact various biological processes that may contribute to a reduction in the rates of aging and age-associated diseases. 3,6 Previous reports have found green tea to extend the lifespan of various animal models. In Caenorhabditis elegans, daily administration of 220 lM of EGCG, its most prevalent and active flavonoid, increased the mean lifespan up to 14%.…”

Section: Introductionmentioning

confidence: 99%

Green Tea Polyphenols Extend the Lifespan of MaleDrosophila melanogasterWhile Impairing Reproductive Fitness

Lopez

Schriner

Okoro

et al. 2014

Journal of Medicinal Food

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Green tea is a popular beverage believed to have many health benefits, including a reduction in the risks of heart disease and cancer. Rich in polyphenolic compounds known as catechins, green tea and its components have been shown to increase the lifespan of various animal models, including Drosophila melanogaster. Here, we investigated the genderspecific effects of green tea on the lifespan of fruit flies and observed that green tea extended the lifespan of male flies only. This effect was found to be independent of typical aging interventions, such as dietary restriction, modulation of oxidative energy metabolism, and improved tolerance to environmental stresses. The one exception was that green tea did protect male flies against iron toxicity. Since there is an inverse correlation between lifespan and reproduction, the impact of green tea on male reproductive fitness was also investigated. We found that green tea negatively impacted male fertility as shown by a reduced number of offspring produced and increased mating latency. We further identified that the lifespan extension properties of green tea was only observed in the presence of females which alludes to a reproductive (or mating) dependent mechanism. Our findings suggest that green tea extends the lifespan of male flies by inhibiting reproductive potential, possibly by limiting iron uptake. To our knowledge, our study is the first to report the negative impact of green tea on Drosophila male reproduction. Our results also support previous studies that suggest that green tea might have a negative effect on reproductive fitness in humans.

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“…Iron accumulation occurs in specific areas of the brain where degeneration occurs, in both PKD and AD (Riederer et al, 1989). In AD, the free iron pool leads to neocortical amyloid β peptide (Aβ) deposition, the hyperphosphorylation of tau (PHF-τ, a major component of neurofibrillary tangles) and tangle formation (Weinreb et al, 2004).…”

Section: Neurodegenerative Disordersmentioning

confidence: 99%

Role of tea catechins in prevention of aging and age-related disorders

Khanna¹,

Maurya²

2012

TANG [HUMANITAS MEDICINE]

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Tea polyphenols especially catechins have long been studied for their antioxidant and radical scavenging properties. Scientists throughout the world have investigated the usefulness of the regular green tea consumption in several disease conditions. In-vitro and in-vivo experiments on catechins especially epigallocatechingallate have revealed a significant role in many ways. Reactive oxygen species have been increasingly implicated in the pathogenesis of many diseases and important biological processes. Toxic effects of these oxidants, commonly referred to as oxidative stress, can cause cellular damage by oxidizing nucleic acids, proteins, and membrane lipids. Oxidative stress has been related to aging and age related disorders. It is found that in a wide variety of pathological processes, including cancer, atherosclerosis, neurological degeneration, Alzheimer's disease, ageing and autoimmune disorders, oxidative stress has its implications. Catechins have been reported to be useful in combating aging and age related disorders like cancer, cardiovascular disorders and neurodegenerative diseases. In this mini review we will discuss such studies done across the globe.

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Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases

Cited by 445 publications

References 116 publications

Green Tea Catechin Polyphenols Attenuate Behavioral and Oxidative Responses to Intermittent Hypoxia

Green Tea Catechin Polyphenols Attenuate Behavioral and Oxidative Responses to Intermittent Hypoxia

Green Tea Polyphenols Extend the Lifespan of MaleDrosophila melanogasterWhile Impairing Reproductive Fitness

Role of tea catechins in prevention of aging and age-related disorders

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