2023
DOI: 10.1186/s40001-023-01293-2
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Neurological manifestations of SARS-CoV-2: complexity, mechanism and associated disorders

Kritika Tyagi,
Prachi Rai,
Anuj Gautam
et al.

Abstract: Background Coronaviruses such as Severe Acute Respiratory Syndrome coronavirus (SARS), Middle Eastern Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) are associated with critical illnesses, including severe respiratory disorders. SARS-CoV-2 is the causative agent of the deadly COVID-19 illness, which has spread globally as a pandemic. SARS-CoV-2 may enter the human body through olfactory lobes and interact with the angiotensin-converting enzyme2 (ACE… Show more

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Cited by 12 publications
(5 citation statements)
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References 149 publications
(198 reference statements)
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“…Although the neurological manifestations were consistent across all pandemic waves, the frequency of these manifestations varied based on the wave of the pandemic and the age of the patient. The neurological manifestations described in this study have been documented in scienti c literature, including rare cases [51][52][53][54][55][56][57][58][59][60][61][62].…”
Section: Discussionmentioning
confidence: 99%
“…Although the neurological manifestations were consistent across all pandemic waves, the frequency of these manifestations varied based on the wave of the pandemic and the age of the patient. The neurological manifestations described in this study have been documented in scienti c literature, including rare cases [51][52][53][54][55][56][57][58][59][60][61][62].…”
Section: Discussionmentioning
confidence: 99%
“… 41 , 42 , 43 , 44 COVID‐19 is actually characterized by a cytokine storm, in which the immune system plays a regulatory role in summoning cytokines to attack pathogens. 45 This meta‐analysis was performed to assess the diagnostic value of circulating calprotectin in the severity of COVID‐19. Eventually, we found that levels of circulating calprotectin were positively associated with the severity and mortality outcome of COVID‐19 patients.…”
Section: Discussionmentioning
confidence: 99%
“…SARS-CoV-2 predominantly causes symptoms of the respiratory tract but also may affect multiple organ systems, which can lead to various, and in some cases severe, symptoms, including organ failure [19][20][21][22][23][24]. A certain type of this systemic disease in children is known under the name of MIS-C [25][26][27][28].…”
Section: Discussionmentioning
confidence: 99%