Neurological Manifestations of Neoplastic and Radiation-Induced Plexopathies

Jaeckle, Kurt A.

doi:10.1055/s-2004-861533

Cited by 109 publications

(49 citation statements)

References 31 publications

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“…The frequency of lumbosacral plexopathy in patients with cancer, which is not specific to MPS, has been reported as 0.71% (4). However, such a low frequency may reflect significant under-recognition of MPS (3,4).…”

Section: Literature Review and Discussionmentioning

confidence: 99%

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Malignant psoas syndrome associated with gynecological malignancy: Three case reports and a review of the literature

et al. 2018

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Abstract. Malignant psoas syndrome (MPS) is a rare and unique cancer-associated syndrome caused by the malignant involvement of the psoas major muscle, and is characterized by ipsilateral lumbosacral plexopathy and painful hip flexion. The pain in MPS is often distressing and intractable, and there is no established effective treatment approach. Herein, the present study reports on three cases of MPS associated with gynecological malignancies, wherein symptom improvement was observed following chemotherapy or radiotherapy. Among 39 cases documented in the literature, female genital tract malignancies were the most frequent causes of MPS; however, the condition may be under-diagnosed, owing to the lack of general recognition. Considering the development of recent high-precision radiation therapy, palliative radiotherapy may serve an important role in the management of MPS. For physicians treating gynecological cancers, early detection of MPS is clinically important as this may allow patients to receive possible therapies and improve their quality of life in end-stage cancer. Further prospective studies should be performed to evaluate effective therapeutic approaches for MPS.

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Section: Literature Review and Discussionmentioning

confidence: 99%

“…MPS is a rare entity, and its incidence has been reported to be less than 1% among patients with high-risk cancer, although this value may reflect under-recognition of the disease (3,4).…”

Section: Introductionmentioning

confidence: 99%

Malignant psoas syndrome associated with gynecological malignancy: Three case reports and a review of the literature

et al. 2018

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“…Brachial plexopathy most commonly occurs in carcinoma of the breast and lung, and lumbosacral plexopathy is most commonly associated with colorectal and gynecologic tumors, sarcomas, and lymphomas. Regardless of the location, neoplastic plexopathy is often characterized by severe, unrelenting pain 40 .…”

Section: Neuropathic Pain In Lung Cancermentioning

confidence: 99%

A Contemporary Perspective on Therapeutic Measures and Approaches to Pain Management in Lung Cancer

Türker¹,

Akpınar²,

Ünsal³

2016

Kafkas J Med Sci

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“…MRI of the brachial plexus and cervical spinal cord were normal. The lack of pain, conduction blocks on nerve conduction study, 1 and cramp-fasciculation potentials in muscles within the radiation field suggested a diagnosis of post irradiation rhythmic muscle cramp-fasciculation disorder. …”

mentioning

confidence: 99%

“…1 Excess motor unit activity (EMUA) after irradiation manifests as myokymia and neuromyotonia in affected muscles. 2,3 A 65-year-old woman presented with a pulling sensation in the left axilla and intermittent depression of the left arm of 3 to 4 months duration.…”

mentioning

confidence: 99%

Postirradiation localized cramp-fasciculation syndrome

Maramattom¹,

Abraham²

2006

Neurology

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Radiation plexopathy produces numbness, weakness, and reflex changes.1 Excess motor unit activity (EMUA) after irradiation manifests as myokymia and neuromyotonia in affected muscles. 2,3A 65-year-old woman presented with a pulling sensation in the left axilla and intermittent depression of the left arm of 3 to 4 months duration. Ten months earlier she had completed chemotherapy and radiation therapy after a simple mastectomy for breast carcinoma 3 years earlier. On examination, frequent (2 to 3 per minute) intermittent rhythmic contractions of the left latissimus dorsi and pectoralis major muscles were seen (figure 1) (see also accompanying video). The duration of contractions ranged from 3 to 60 seconds during which her left arm was adducted and depressed and an accessory posterior axillary fold was created. No fasciculations or myokymia were observed. Nerve conduction studies showed conduction blocks in the left median and ulnar nerves across Erb's point. Needle EMG demonstrated rhythmic cramp discharges and occasional fasciculation potentials in the left latissimus dorsi, teres major, and pectoralis major muscles (figure 2). No myokymic, neuromyotonic, or fibrillation potentials were seen. MRI of the brachial plexus and cervical spinal cord were normal. The lack of pain, conduction blocks on nerve conduction study, 1 and cramp-fasciculation potentials in muscles within the radiation field suggested a diagnosis of post irradiation rhythmic muscle cramp-fasciculation disorder.

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Neurological Manifestations of Neoplastic and Radiation-Induced Plexopathies

Cited by 109 publications

References 31 publications

Malignant psoas syndrome associated with gynecological malignancy: Three case reports and a review of the literature

Malignant psoas syndrome associated with gynecological malignancy: Three case reports and a review of the literature

A Contemporary Perspective on Therapeutic Measures and Approaches to Pain Management in Lung Cancer

Postirradiation localized cramp-fasciculation syndrome

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