Neurological manifestations of gnathostomiasis

Boongird, Prasert; Phuapradit, P; N, Siridej; Chirachariyavej, Thamrong; Chuahirun, S; Vejjajiva, Athasit

doi:10.1016/0022-510x(77)90113-7

Cited by 92 publications

(66 citation statements)

References 11 publications

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“…Gnanthostoma spinigerum causes a particularly severe form of eosinophilic myeloencephalitis that may result in nerve root pain, paralysis of an extremity, and subarachnoid hemorrhage associated with visceral and cutaneous larvae migrans . 19 In our study three cases of eosinophilic meningitis have been encountered. the cause were filiariasis, fasciolosis and tubercular meningitis.…”

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confidence: 63%

Clinical and Laboratory Profile of Children with Eosinophilia at Dhulikhel Hospital

Shrestha

Dongol

Shrestha

et al. 2013

Kathmandu Univ. Med. J.

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BackgroundEosinophilia in children is commonly caused by or parasitic, allergic and immunologic problems. ObjectivesTo study clinical and laboratory profile of patients with eosinophilia and to identify possible causes. MethodA prospective and descriptive study was conducted from January 2009-December 2011. All the cases of eosinophilia with symptoms and signs of single or multiple organ were included. The known caused of eosinophilia like allergy, asthma and drugs were excluded. ResultsDuring three years period, 84(2.41%) cases had eosinophilia with single or multiple organ involment. 14.3%, 39.3% and 46.4% had mild, moderate and severe eosinophilia respectively, with cases of hypereosinophilia comprising 85.7%. Eosinophilia is seen predominantly in tamang caste with overall age ranging from 1-14 years. Most common symptoms and signs are abdominal pain (67.9%) hepatomegaly (59.5%) respectively. Gastrointestinal system was most commonly involved organ followed by respiratory system. Nineteen percent had polyserositis involving pleural, pericardial effusion and ascites at presentation. Out of 84 patients only nine serum samples were able to be sent for parasitological analysis. sixteen had identifiable and/ or possible causes. Serum sample for parasitological analysis revealed fascilosis, filariasis, strongylosis stercoralis and toxocariasis. ConclusionEosinophilia is more common among tamang poulation in our study. Most common symptoms and signs are abdominal pain and hepatomegaly respectively. Parasitic infection seems to be the most common cause however further study has to be done to reach final conclusion.

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confidence: 63%

Clinical and Laboratory Profile of Children with Eosinophilia at Dhulikhel Hospital

Shrestha

Dongol

Shrestha

et al. 2013

Kathmandu Univ. Med. J.

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“…Unexplained subarachnoid hemorrhage was defined as subarachnoid hemorrhage with negative results for intracranial aneurysm or arteriovenous malformation by cerebral angiogram. [4][5][6][7][8][9][10] In addition, all patients were required to have negative serologic results for Angiostrongylus cantonensis (rodent lungworm), Paragonimus heterotremus (lung fluke), Fasciola gigantica (cattle liver fluke), and Cysticercus cellulosae (pork tapeworm cysticerci).…”

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confidence: 99%

Immunoblot Diagnostic Test for Neurognathostomiasis

Intapan¹,

Khotsri²,

Kanpittaya³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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Neurognathostomiasis is a rare but severe form of human gnathostomiasis. Diagnosis of neurognathostomiasis is made presumably by using clinical manifestations. Serologic tests for neurognathostomiasis are not widely available and limited. We studied 12 patients with diagnoses of neurognathostomiasis at Srinagarind Hospital, Khon Kaen University, Thailand. There were three types of neurognathostomiasis (five patients with intracerebral hemorrhage, one patient with subarachnoid hemorrhage, and six patients with myelitis). All patients were tested for antibodies against Gnathostoma spinigerum by an immunoblotting technique. The sensitivity and specificity of the 21-kD and 24-kD diagnostic bands were 83.3% and 100%, and 91.7% and 100%, respectively. The sensitivity, specificity, positive predictive value, and negative predictive value for the 21-kD and 24-kD diagnostic bands were all 100%. Both diagnostic bands are a helpful diagnostic tool for neuro gnathostomiasis and show good diagnostic properties.

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“…This form causes more illness and deaths, with mortality rates reported at 8%-25%, than the cutaneous form (9,10). Pathogenicity is thought to result from direct mechanical injury by the larvae and by their release of secretions and excretions, which contain various compounds that cause tissue damage (9).…”

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confidence: 99%