Neurological Manifestation of COVID-19: A Literature Review

Abstract

, the new noronavirus (COVID-19) burst occurred in China. 1,2 Chinese governments announced new undetermined etiology subjects of pneumonia. 3 At first, all patients were concentrated into the wholesale market of Wuhan seafood. It was reported a pandemic by the World Health Organization (WHO), on 11 March 2020. There are far beyond 8 million validated COVID-19 cases beside 700,000 deaths worldwide as of August 16, 2020. 4,5 COVID-19 created a vast deal of importance amid researchers, scientists, and physicians around the world. 6 The volume of work being performed and the quantity of papers written on COVID-19 is unparalleled. Hundreds of manuscripts were estimated to be published upon this subject from the beginning of the year. 7 Data have begun to emerge on various features of prevention, transmission, pathology, disease manifestations, and management strategies. 8-10 Although COVID-19 has a beneficial effect on the respiratory and cardiovascular system, many COVID-19 patients are additionally prone to neurological manifestations (such as neuralgia, hypogeusia, dizziness, and headache) and complexities including acute cerebrovascular diseases, encephalopathy, skeletal muscle injury, and impaired consciousness. 11,12 We are offering a systematic study of COVID-19's clinical manifestations and complications. They aim to educate the neurologists, and doctors dealing with presumed COVID-19 patients on potential neurological symptoms and the likely neurological problems arising from this novel infection with the virus. Literature Search Strategy We searched PubMed Central, Medline, and Google scholar using the keywords "pandemic", " COVID-19", "neurology", "complications", "SARS-COV-2", "Coronavirus", and "manifestations". Single English language scripts without time-end were looking. The latest scan of the literature was conducted on August 1st, 2020. It is essential to remember that fresh data are frequently exchanged and so considerably it consists generally of preprints, small case collection, case reports, and part of an article discussing COVID-19 clinical characteristics. Most of the COVID-19 evidence is released from Wuhan city, China. 13 At the time of writing this paper, we were capable to find in-depth hardly 34

Neurological Manifestation in Hospitalized Patients With Acute SARS-CoV-2 Infection

“…Some patients with COVID-19 may have neurological symptoms as the initial presentation of the disease [ 13 ]. However, the prevalence of neurological signs and symptoms is higher in patients with a severe COVID-19 infection, which may be a consequence of cerebral hypoxia due to respiratory failure [ 14 ].…”

Neurological findings associated with neuroimaging in COVID-19 Patients

“…Over 10,000 people worldwide have contracted MERS-CoV and SARS-CoV outbreaks over the past 20 years 8,9 . According to several studies, neurologic sequelae, such as seizures, Guillain-Barre syndrome (GBS), encephalopathy, anosmia, encephalitis, neuromuscular abnormalities, as well as demyelinating illnesses, may develop in connection with respiratory coronavirus syndromes [10][11][12][13] . The ability to invade and live in neural tissue of additional coronaviruses of humans, such as HCoV-NL63, HCoV-HKU1, HCoV-OC43, and HCoV-229E, as well as the potential links to neurological conditions including multiple sclerosis disease (MS), has also been disputed 14,15 .…”

“…In spite of the fact that COVID-19 positively influences the cardiovascular and respiratory systems, and many COVID-19 patients are also susceptible to neurological complications like acute cerebrovascular diseases, encephalopathy, skeletal muscle injury, and impaired consciousness. These complications include neuralgia, hypogeusia, dizziness, and headache 11,12 . Although the literature on COVID-19's characteristic respiratory presentation has received much attention 7 , there is a dearth of in-depth research on its cerebral symptoms, particularly the radiological findings.…”

A qualitative analysis of literature reporting and linking psychosis to COVID-19 infection. Findings from a postgraduate journal club

“…( AIIMS/ ICMR-COVID-19, , American Psychiatric Association, & American Psychiatric Association, 2013 , Azhideh et al, 2020 , Andrade, 2011 Apr , Banerjee and Viswanath, 2020 , Bodnar et al, 2021 Apr , Boutron and Ravaud, 2018 , Chapnick, 2019 , Dewan and Gupta, 2016 Mar 1 , Hyland et al, 2020 , Kirkpatrick and Miller, 2013 , Lahiri and Ardila, 2020 Apr , Lewis and Smith, 1983 , Megahed and Ghoneim, 2020 , Mølhave, 2021 , Rehman et al, 2021 Jan , Sanchez-Alonso et al, 2020 Aug 1 , Upadhyaya and James, 2019 Apr 4 , World Health Organization, 2004 Dec 31 )…”