Neurological Manifestation of Colonic Adenocarcinoma

Sio, Terence T.; Paredes, Mercedes F.; Chaudhary, Uma

doi:10.4081/rt.2012.e32

Cited by 9 publications

(7 citation statements)

References 11 publications

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“…In all the reported cases, [ 4 – 6 ] the neurological symptoms preceded the diagnosis of tumor, and in one of them they coincided with tumor progression; [ 7 ] differently, our patient developed the PLE 4 years after the radical resection of the primary colon cancer and 2 months after the diagnosis of metastases from colon neoplasm, while receiving a very active first-line chemotherapy by which a partial reduction of the tumor burden was obtained.…”

Section: Discussionmentioning

confidence: 75%

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A case report of limbic encephalitis in a metastatic colon cancer patient during first-line bevacizumab-combined chemotherapy

Attademo

Falco²,

Rosanova³

et al. 2018

Medicine

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Rationale:Paraneoplastic limbic encephalitis (PLE) is one of the most common causes of neurologic paraneoplastic syndromes, with unclear pathogenesis. While several reports published in the last decades showed the occurrence of PLE in a variety of cancers, only a few cases have been associated with colon cancer.Patient concerns:In February 2017, a 54-year-old man with clinical history of radically resected colon cancer started first line chemotherapy with FOLFOXIRI plus bevacizumab, after radiological diagnosis of multiple liver and bone metastases. During the third cycle of treatment, the patient developed psychomotor agitation and hallucinations followed by severe consciousness level reduction and cognitive impairment.Diagnoses:Magnetic resonance imaging showed hyperintense signals in both hippocampal areas, insula and right cingulate gyrus on fluid attenuated inversion recovery, diffusion weighted imaging, and T2-weighted images, highly suggestive of limbic encephalitis. Other causes (brain metastases, toxicity of chemotherapeutic agents, and infections) were excluded.Interventions:Empirical immunosuppressive treatment (high-dose immunoglobulins and corticosteroids) was administered and chemotherapy was resumed.Outcomes:A slowly progressive improvement in neurological condition has been observed, even though radiological signs of limbic encephalitis are still evident.Lessons:The present case highlights the complex diagnostic process of PLE, and the lack of a standard treatment. Moreover, the absence of correlation between PLE and tumor progression or tumor burden, and the opportunity of treating underlying neoplasm is discussed.

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Section: Discussionmentioning

confidence: 75%

“…Sio et al [ 4 ] describe the story of a 53-year-old man who simultaneously developed a sensory neuropathy and a limbic encephalitis. The diagnosis of metastatic colon cancer was done during the diagnostic work-up for the neurologic symptoms.…”

Section: Discussionmentioning

confidence: 99%

A case report of limbic encephalitis in a metastatic colon cancer patient during first-line bevacizumab-combined chemotherapy

Attademo

Falco²,

Rosanova³

et al. 2018

Medicine

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“…However, no testing for neuro-oncologic antibodies was performed. Paraneoplastic neurological syndromes due to colon cancer are extremely rare, with sensory neuropathy and vasculitis having been described [ 11 ]. Of note, it has been observed that tumors causing paraneoplastic neurologic disorders are often “heavily infiltrated with inflammatory cells” and have a better prognosis than histologically identical tumors with no paraneoplastic neurologic manifestations [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Medullary colon cancer presenting with total necrosis of all regional lymph node metastases: morphologic description of a presumed immune-mediated event

Mitchell

Bendavid

2014

Diagn Pathol

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Medullary carcinoma is a rare type of colon cancer with characteristic clinical and molecular features. Notably, despite its high-grade histology, the prognosis is generally better than for colonic adenocarcinoma of the usual type. We present herein a singular case of medullary colon cancer in which all of numerous lymph node metastases in the surgical resection specimen were completely necrotic in the face of a wholly viable primary tumor. Possible mechanisms are discussed with emphasis on immune-mediated factors.Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_204

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“… 2 We aim to collect, analyze, and ultimately publish quality clinical data on either a rare type of cancers in which radiotherapy and/or chemoradiation play an important role, or rare presentations of common cancers which are of interest to the globally practicing radiation oncologists, including management of unusual paraneoplastic syndromes. 3 , 4 The most common tool for clinical investigation is typically retrospective methods, however, prospectively followed protocols and registries (J. Thariat) and case control studies (other investigators) have been previously proposed. The announcement of new studies must first be coordinated with the secretariat office (B. Pointet) so that RCN research activities can be tracked.…”

Section: A Brief History Of the Rare Cancer Networkmentioning

confidence: 99%

The Present and Future Opportunities of the Rare Cancer Network: An International Consortium for Advancement of Oncologic Care

Önal¹

2015

Rare Tumors

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To date, the Rare Cancer Network (RCN) has initiated more than 90 studies and 54 peer-reviewed publications were produced as a result. The Second International Symposium of the Rare Cancer Network recently took place in Istanbul, Turkey on April 17-18, 2015, and update was given on multiple currently ongoing projects, while also giving room for new proposals which will shape the direction of future studies for the group. This companion issue of the RCN Proceedings summarized the findings of this meeting, while also serving as a call for fresh projects and papers which will continue to energize the group and advance the oncologic science. A brief introduction to the principles, history, and vision of the RCN was also included. To review, the academic year of 2014-15 marked an enormous success for the international members of the RCN, with the generation of 8 fully published papers and more than 12 newly proposed topics. By the collective efforts of all RCN members, in the future, we look forward to the upcoming opportunities in continuing to advance the standard of chemo- and radiotherapeutic oncologic care for selected rare tumor topics. The studies of these rare cancers often do not allow the design and execution of prospectively enrolled trials; however, these uncommon malignancies do impact the humankind and add to its suffering globally in significant ways.

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Neurological Manifestation of Colonic Adenocarcinoma

Cited by 9 publications

References 11 publications

A case report of limbic encephalitis in a metastatic colon cancer patient during first-line bevacizumab-combined chemotherapy

A case report of limbic encephalitis in a metastatic colon cancer patient during first-line bevacizumab-combined chemotherapy

Medullary colon cancer presenting with total necrosis of all regional lymph node metastases: morphologic description of a presumed immune-mediated event

The Present and Future Opportunities of the Rare Cancer Network: An International Consortium for Advancement of Oncologic Care

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