Neurological disease activity in multiple sclerosis patients with periphlebitis retinae

Engell, Tine

doi:10.1111/j.1600-0404.1986.tb03259.x

Cited by 26 publications

(3 citation statements)

References 15 publications

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“…These have been demonstrated to be associated with risk of cerebral vascular disease even after adjusting for systemic vascular risk factors [20]. Quantitative retinal blood vessel metrics are potential markers of MS based on the known clinical relationships between MS and retinal vessel inflammation [17,21,22], and between MS and ganglion cell loss, which potentially decreases metabolic demand [23,24]. However, these relationships have not been thoroughly explored using OCT.…”

Section: Introductionmentioning

confidence: 99%

Detection of retinal blood vessel changes in multiple sclerosis with optical coherence tomography

Bhaduri

Nolan

Shelton

et al. 2016

Biomed. Opt. Express

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Although retinal vasculitis is common in multiple sclerosis (MS), it is not known if MS is associated with quantitative abnormalities in retinal blood vessels (BVs). Optical coherence tomography (OCT) is suitable for examining the integrity of the anterior visual pathways in MS.In this paper we have compared the size and number of retinal blood vessels in patients with MS, with and without a history of optic neuritis (ON), and control subjects from the cross-sectional retinal images from OCT. Blood vessel diameter (BVD), blood vessel number (BVN), and retinal nerve fiber layer thickness (RNFL T ) were extracted from OCT images collected from around the optic nerves of 129 eyes (24 control, 24 MS + ON, 81 MS-ON) of 71 subjects. Associations between blood vessel metrics, MS diagnosis, MS disability, ON, and RNFL T were evaluated using generalized estimating equation (GEE) models. MS eyes had a lower total BVD and BVN than control eyes. The effect was more pronounced with increased MS disability, and persisted in multivariate models adjusting for RNFL T and ON history. Twenty-nine percent (29%) of MS subjects had fewer retinal blood vessels than all control subjects. MS diagnosis, disability, and ON history were not associated with average blood vessel size. The relationship between MS and lower total BVD/BVN is not accounted for by RNFL T or ON. Further study is needed to determine the relationship between OCT blood vessel metrics and qualitative retinal blood vessel abnormalities in MS. Huang, "Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis," Br. J. Ophthalmol. 98(10),

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Section: Introductionmentioning

confidence: 99%

Detection of retinal blood vessel changes in multiple sclerosis with optical coherence tomography

Bhaduri

Nolan

Shelton

et al. 2016

Biomed. Opt. Express

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“…Its presence is thought to be more common in active stages of the disease and its pathogenesis may share commonalities with perivenular inflammation in typical MS plaques 95,96,98,99. Retinal periphlebitis in MS is typically mild and may not have any clinical manifestations; more severe cases may be seen in disorders such as sarcoid, syphilis, toxoplasmosis, Eale disease, and idiopathic uveitis 100…”

Section: The Afferent Visual System In Msmentioning

confidence: 99%

Eye disorders in patients with multiple sclerosis: natural history and management

Graves

Balcer

2010

OPTH

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Multiple sclerosis (MS) is a demyelinating disease of the central nervous system and leading cause of disability in young adults. Vision impairment is a common component of disability for this population of patients. Injury to the optic nerve, brainstem, and cerebellum leads to characteristic syndromes affecting both the afferent and efferent visual pathways. The objective of this review is to summarize the spectrum of eye disorders in patients with MS, their natural history, and current strategies for diagnosis and management. We emphasize the most common disorders including optic neuritis and internuclear ophthalmoparesis and include new techniques, such as optical coherence tomography, which promise to better our understanding of MS and its effects on the visual system.

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“…Quantitative retinal blood vessel metrics are potential markers of MS due to a known clinical relationship between MS and retinal vessel inflammation [ 13 , 14 , 15 ], and between MS and RGC loss, which potentially decreases the metabolic demand [ 16 , 17 ]. Structural and physiological abnormalities have been reported in the retina in pwMS [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring Retinal Blood Vessel Diameters as Biomarkers in Multiple Sclerosis

Nes

Berg‐Hansen

Benavent

et al. 2022

JCM

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We aimed to determine whether retinal vessel diameters and retinal oxygen saturation in newly diagnosed patients with multiple sclerosis (pwMS) are different from those of a healthy population. Retinal blood vessel diameters were measured using imaging with a spectrophotometric non-invasive retinal oximeter. Twenty-three newly diagnosed untreated relapsing-remitting MS (RRMS) patients (mean age: 32.2 ± 7.5 years, age range = 18–50 years, 56.5% female) were measured and compared to 23 age- and sex-matched healthy controls (HCs) (mean age: 34.8 ± 8.1 years). Patients with Optic Neuritis were excluded. Retinal venular diameter (143.8 µm versus 157.8 µm: mean; p = 0.0013) and retinal arteriolar diameter (112.6 µm versus 120.6 µm: mean; p = 0.0089) were smaller in pwMS when compared with HCs, respectively. There was no significant difference in the oxygen saturation in retinal venules and arterioles in pwMS (mean: 60.0% and 93.7%; p = 0.5980) compared to HCs (mean: 59.3% and 91.5%; p = 0.8934), respectively. There was a significant difference in the median low contrast visual acuity (2.5% contrast) between the pwMS and the HC groups (p = 0.0143) Retinal arteriolar and venular diameter may have potential as objective biomarkers for MS.

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Neurological disease activity in multiple sclerosis patients with periphlebitis retinae

Cited by 26 publications

References 15 publications

Detection of retinal blood vessel changes in multiple sclerosis with optical coherence tomography

Detection of retinal blood vessel changes in multiple sclerosis with optical coherence tomography

Eye disorders in patients with multiple sclerosis: natural history and management

Exploring Retinal Blood Vessel Diameters as Biomarkers in Multiple Sclerosis

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