Neurological consequences of psychotropic drug withdrawal in schizophrenic children

Polizos, Polizoes; Engelhardt, David M.; Hoffman, Stanley P.; Waizer, Jonas

doi:10.1007/bf01538282

Cited by 88 publications

(9 citation statements)

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“…Withdrawal-emergent syndrome was first described in 1973 by Polizos et al [2] as choreatic movements in children after abrupt discontinuation of an antipsychotic drug after long-term use. The symptoms usually manifest during the first few days or weeks after discontinuation of dopamine receptor-blocking agents.…”

Section: Discussionmentioning

confidence: 99%

Amisulpride withdrawal dyskinesia: a case report

Peng

2017

Ann Gen Psychiatry

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BackgroundThe effects of antipsychotic drug withdrawal have been inadequately studied. Case reports have described dyskinesia occurring in patients with several antipsychotics withdrawn, but studies on amisulpride withdrawal dyskinesia are lacking.Case presentationA 63-year-old man, who was diagnosed with schizophrenia at age 49, received amisulpride treatment since age 62. The dosage of amisulpride was reduced from 200 to 50 mg/day because of occurrence of akathisia during one admission. Severe withdrawal dyskinesia, mixed with dystonia and akathisia, was noted immediately after the dosage reduction. The abnormal involuntary movement showed improvement 2 weeks later when the dosage was increased to 100 mg/day.ConclusionsWithdrawal dyskinesia and other abnormal involuntary movements could be noted in a patient with reduction of amisulpride dosage or sudden termination. Withdrawal dyskinesia may subsequently lead to persistent tardive dyskinesia. Therefore, withdrawal-emergent dyskinesia should be promptly identified, and appropriate medical interventions should be given early.Electronic supplementary materialThe online version of this article (doi:10.1186/s12991-017-0148-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Amisulpride withdrawal dyskinesia: a case report

Peng

2017

Ann Gen Psychiatry

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“…Campbell et al (14) reported a TD rate of 22% after only 30 months in 36 children receiving haloperidol. Others have reported even higher rates of 41% and 48% (15,16).…”

Section: Childrenmentioning

confidence: 94%

Focus on Lower Risk of Tardive Dyskinesia with Atypical Antipsychotics

Nasrallah

2006

Annals of Clinical Psychiatry

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“…Similarly, a variety of genetic and neurodegenerative conditions can cause tics, including Wilson disease, neuroacanthocytosis 8 9 , neurodegeneration with brain iron accumulation 10 11 and Huntington disease 12 .Other potential causes of tics include lesions involving frontal-subcortical circuits like trauma 13 , carbon monoxide poisoning 14 , hypoxic-ischemic encephalopathy and stroke 15 ; central nervous system (CNS) infections (neuroborreliosis 16 , viral encephalitis 17 ) and central nervous system immune disorders (like antiphospholipid antibody syndrome 18 , Sydenham'schorea 19 ). Tics can be a manifestation of neuroleptic drug-related tardive dyskinesia 20 or withdrawal emergent syndrome 21 . Induction or exacerbation of tics has been reported with antiepileptic drugs 22 23 , cocaine 24 , caffeine 25 and stimulants 26 .…”

Section: Secondary Tic Disordersmentioning

confidence: 99%