Neurological complications of primary Sjögren's syndrome

Lafitte, C; Amoura, Zahir; Cacoub, Patrice; Pradat‐Diehl, Pascale; Picq, C.; Salachas, François; Léger, Jean‐Marc; Piette, Jean‐Charles; Delattre, J.

doi:10.1007/s004150170135

Cited by 163 publications

(124 citation statements)

References 33 publications

(44 reference statements)

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“…The results from other countries suggest that patients with PSS display cognitive impairments in attention, memory, speed of information processing, and executive function, indicating a pattern of frontal-subcortical dysfunction 9 . Psychiatric alterations have also been reported to be associated with cognitive impairments related to diffuse encephalic manifestations 5,10 .…”

mentioning

confidence: 90%

A short neuropsychological evaluation of patients with primary Sjögren's syndrome

Rodrigues

Hora

Salgado

et al. 2014

Arq. Neuro-Psiquiatr.

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Objective: To investigate cognitive deficits in patients with primary Sjögren's syndrome (PSS). Method: Eighteen patients with PSS, aged between 25 and 61 years, were subjected to a short neuropsychological battery and compared with 18 patients with multiple sclerosis and 18 healthy controls. Results: The analysis of variance (ANOVA) revealed that the clinical groups had significantly worse performance than the control group on the Rey Auditory Verbal Learning Test 3; (F 2,53 =3.500, p=0.038) and 7 (F 2,53 =5.068, p=0.010). The clinical groups had elevated levels of depression on the Beck Depression Inventory (BDI); (p=0.003). The analysis of the data from the Trail Making Test B-A revealed a significant difference between the clinical and control groups (p=0.023). The analysis of covariance with BDI score as a covariate, did not change the outcome. Conclusion: Our study revealed cognitive deficits in patients with PSS detectable by a short neuropsychological battery.Keywords: neuropsychological evaluation; Sjögren's syndrome, cognitive impairment, neuropsychology. Primary Sjögren's syndrome (PSS) is an inflammatory autoimmune disease characterized by infiltration of exocrine glands. It occurs without an association with other connective tissue diseases and affects mainly salivary and lachrymal glands, causing xerostomy and keratoconjunctivitis sicca 1,2 . It often afflicts middle-age women, with an estimated prevalence of 2% in the adult population 3 . Moreover, PSS can be associated with impairments of the nervous system. In the central nervous system (CNS), the focal and nonfocal involvement of the brain and spinal cord has been described, resulting in a wide spectrum of neurological, psychiatric, and cognitive symptoms 4 .Cognitive impairments in patients with PSS were reported by Malinow 5 and later confirmed by other studies 6,7 . In Brazil, we have not found any case-series studies that have investigated cognitive impairments in PSS. We found one case report 8 .The results from other countries suggest that patients with PSS display cognitive impairments in attention, memory,

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confidence: 90%

A short neuropsychological evaluation of patients with primary Sjögren's syndrome

Rodrigues

Hora

Salgado

et al. 2014

Arq. Neuro-Psiquiatr.

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“…63 Case reports have described a patient with an amnestic syndrome 64 and another with Klüver-Bucy-like symptoms 65 in CNS Whipple’s disease, which highlights the variable presentation in this disease. Sjögren’s syndrome 66 –69 and Behçet’s disease 70 –72 — both autoimmune disorders— can involve the CNS as well, causing cognitive and personality changes (Table 2). …”

Section: Encephalopathy In Lupus and Other Systemic Syndromesmentioning

confidence: 99%

The Emerging Link Between Autoimmune Disorders and Neuropsychiatric Disease

Kayser¹,

Dalmau²

2011

Journal of Neuropsychiatry

115

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“…It was concluded that the local decrease of neuropeptides in the salivary glands may contribute to the atrophy and functional deficiency of salivary glands (Lafitte, 2002;Batbayar et al, 2004). Our preliminary results showed that the PEF treatment exerted similar effect on the peptidergic innervation pattern of sweat glands, the minor salivary glands of tongue and oral mucosa of the rat (unpublished data).…”

Section: Modification Of Innervation In Salivary Glandmentioning

confidence: 54%

Modification of Innervation Pattern by Fluoroquinolone Treatment in the Rat Salivary Glands

Kelentey

Deák

Zelles

et al. 2010

The Anatomical Record

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Fluoroquinolone antibiotics (FQAs) are widely used in dental and medical therapy. Despite their known severe adverse actions on the central and peripheral nervous system, little attention has been directed toward the potential toxic side effects of these compounds on the oral tissues. As the saliva secretion is controlled by the nervous system and neuropeptides, the neurotoxic effect of pefloxacin (PEF), a representative member of FQAs, was studied in rats in the present work. Previously, we demonstrated a significant weight loss of parotid gland tissue, a marked decrease in 3H-thymidine incorporation, a decreased volume of saliva and amylase activity of the glandular tissue in response to PEF. Animals received intraperitoneal injection of PEF (20 mg/100 g body weight daily) for 3 and 7 days. Normal histology, and neurofilament 200, substance P (SP) and calcitonin gene-related polypeptide (CGRP) containing nerve fibers were detected with immunohistochemical methods. A marked decrease of the weights in salivary glands and the acinar diameters were measured. Similarly, a strong and significant decrease of the number of SP and CGRP containing nerve fibers were detected. These findings suggest that the impaired morphology and innervation pattern of salivary glands is related to the neurotoxic adverse effect of FQA treatment. Anat Rec,

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Neurological complications of primary Sjögren's syndrome

Cited by 163 publications

References 33 publications

A short neuropsychological evaluation of patients with primary Sjögren's syndrome

A short neuropsychological evaluation of patients with primary Sjögren's syndrome

The Emerging Link Between Autoimmune Disorders and Neuropsychiatric Disease

Modification of Innervation Pattern by Fluoroquinolone Treatment in the Rat Salivary Glands

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