Neurological complications of neuroblastic tumors: experience of a single center

Abstract

The prevalence rates of Horner's syndrome, OMA, CNS metastasis, and SCC were found to be 3.6%, 1.8%, 2.2%, and 9.4%, respectively. Metastasis to the CNS indicated a very poor prognosis. No differences in neurological improvement in patients with SCC were found between those treated with radiotherapy, laminectomy, or chemotherapy alone, but laminectomy and radiotherapy caused significant late sequelae. Early diagnosis and proper management is critical to avoid long-term sequelae in patients with SCC.

Short‐ and long‐term outcome of patients with symptoms of spinal cord compression by neuroblastoma

“…The grade of residual motor impairment after initial neurosurgery was lower but the difference was not statistically significant. Other studies have also reported no difference between either intervention 10–12 . It is of interest that, unlike another study that found that neurosurgery more often leads to scoliosis, 11 we found no difference in levels of scoliosis after either first‐line neurosurgery or chemotherapy.…”

Treatment and outcome of neuroblastoma with intraspinal extension: A systematic review

“…To determine the outcome of this asymptomatic patient group is not straightforward, since it is often not assessed and/or reported . In three studies, it is explicitly mentioned that the asymptomatic patients do not have any long‐term health problems.…”

“…8,46,50 Two studies found a lower rate of disseminated disease compared to NBL patients without spinal cord compression. 46,50 Six studies found an overall survival (OS) benefit for NBL patients with intraspinal extension compared to patients without spinal involvement, 8,37,46,[49][50][51] the difference being significant in only two studies. 46,50 An improved event-free survival (EFS) was reported in four studies, 8,44,50,51 the difference being significant in only one study.…”

“…1,10,34,35,41,46,48,50,51 The severity of the motor deficit at diagnosis was reported in 15 studies. 1,8,10,11,34,37,41,42,[46][47][48][49][50][51]53 The symptom to diagnosis interval, reported as a mean or median, showed considerable variation, ranging from 3 days to 2 months (median 25.5 days). 1,8,10,11,[33][34][35]37,[46][47][48][49][50][51]53 Nineteen studies reported on the prevalence of neurological motor deficit at the end of follow-up, which ranged from 17 to 69% (median 50%).…”

Henoch-Schönlein purpura associated with a neuroblastoma: Report of one case and a review of the literature

“…Neuroblastomas are the most common extracranial solid tumors in children, accounting for about 8%-10% of all pediatric tumors (20,21). That said, there are no reports of HSP associated with a neuroblastoma or other malignancy in children.…”