Neurological Complications of Lymphomas and Leukemias

The relation between chronic polyneuropathy and osteosclerotic myeloma.

“…These numbers do not include certain other reports (Kurnick and Yolahem, 1948, cases 1 and 3; Madonick and Solomon, 1953;Victor, Banker, and Adams, 1958, case 5; Williams, Diamond, Craver, and Parsons, 1959, case J. G.; Barron, Rowland, and Zimmerman, 1960;and Bibliography-1'2), some of which do not describe the cases; in some the clinical picture was complicated by myelomatous compression or infiltration, or amyloid deposition, and in some the neuropathy was not a chronic symmetrical polyradiculoneuropathy. In two recent descriptions the writers comment on the unusual osteosclerotic myeloma in their cases (Small, Moxon, and Woolf, 1961;Aguayo, Thompson, and Humphrey, 1964), and ask whether this is more than a chance association.…”

Primary Reticulum Cell Sarcoma of the Uterus

“…Williams et al (25) noted excellent neurologic recovery in 59 % of 32 patients treated with whole brain irradiation. Thompson et al (18) noted rapid symptomatic improvement in 7 of 8 patients subsequent to radio therapy for intracranial lymphoma.…”

“…Reticulum cell sarcoma produces intracerebral metastases with greater frequency than other lymphomas (24). In the large retrospective study of 5,778 lymphoma and leukemia patients reported in 1950 by Williams et al (25). focal cerebral symptoms, consisting primarily of focal seizures, motor deficits, and cerebellar signs with the exclusion of nonspecific factors such as fever and anemia, were reported to occur in 112 patients or 2%.…”

Über die intracranielle Ausbreitung der Leukämien unter besonderer Berücksichtigung der leukämischen Meningopathie

“…V ir c h o w selbst (zit. 28) beschrieb als einer der Ersten perivasculäre Infiltrate in der Mark-und Rindensubstanz, sowie in subepcndymalen Bezirken und in der Leptomeninx (ältere Literatur: 12,19,5,34 (24,25,37,39,43,44). Man erhält aber doch den Eindruck, daß die intracraniellen resp.…”

“…Wir haben den Fall eines fünfjährigen Knaben mit Stammzcllcnlcukämie beobachtet, der unter der neuen Chemotherapie einen solch typisch andersartigen Verlauf nahm und unter den Zeichen des chronischen Hirndruckes gestorben ist. Da auch in der Literatur in letzter Zeit ähnliche Fälle publiziert wurden (8,9,16,28,29,30,31,35,36,39,40,44,46,47) …”