Neurological complications of dialysis, transplantation, and other forms of treatment in chronic uremia

Hr, Tyler

doi:10.1212/wnl.15.12.1081

Cited by 67 publications

(18 citation statements)

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“…The clinical expression of the studied uremic patients' encephalopathy as well as their EEG recordings was affected by many variables such as electrolyte imbalance, variations in plasma osmolality and/or in pH, changes of blood pressure, and blood perfusion of the brain. Similar observations have also been described by Kiley (4) and other workers (2,6). These concurrent influences were not uniformly present in all examined cases so we are hesitant to make interpretations, even though our findings indicate that patients with clinical evidence of moderate and severe encephalopathy due to chronic uremia have the highest degrees of TKA inhibition.…”

Section: Resultssupporting

confidence: 87%

“…Histopathologic description of the nervous tissue in chronic uremia often reveals degenerative changes of the peripheral and, less frequently, of the central medullated structures (5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Although no definitive information exists as to the mechanism responsible for the morphological and functional changes in the nervous system there are reports which have shown the remarkable resemblance of uremic neuropathy to demyelinative lesions seen in patients with thiamine deficiency (5,7,14).…”

Section: Introductionmentioning

confidence: 99%

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Relationship of nervous tissue transketolase to the neuropathy in chronic uremia

Sterzel¹,

Semar²,

Lonergan³

et al. 1971

J. Clin. Invest.

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A B S T R A C T Patients with chronic uremia develop neurologic defects which are similar to the demyelinating lesions seen in thiamine deficiency. The Hemodialysis markedly reduced the inhibitory effects of the patients' plasma and the data indicate that uremic patients who received effective long-term dialysis treatment show a parallel decline of transketolase inhibition and uremic neuropathy.

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Section: Resultssupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Relationship of nervous tissue transketolase to the neuropathy in chronic uremia

Sterzel¹,

Semar²,

Lonergan³

et al. 1971

J. Clin. Invest.

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“…DDS as is well known, is characterized by neurological symptoms of various importance and gravity (cramps, headaches, vomiting and even disorientation, psychosis and coma) [1,[12][13][14][15] and shows a typical EEG pattern [1,6,7,10,13,14]. Arieff ct al.…”

Section: Discussionmentioning

confidence: 99%

Studies on Brain Density in Hemodialysis and Peritoneal Dialysis

Greca

Biasioli

Chiaramonte

et al. 1982

Nephron

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30 patients on hemodialysis or peritoneal dialysis have been investigated by computerized tomographic (CT) scan. To evaluate possible cerebral alterations induced by dialysis, CT examinations were carried out before, immediately after and 6 h after the end of dialysis with an Evaluskop, which provides an objective precise evaluation of even slight variations in brain density. No morphological variations were noted after dialysis, while the brain density fell significantly during and after the treatment. A decrease in density was not observed in normal subjects or in patients on continuous peritoneal dialysis. The changes in the densitometric values of brain tissue suggest that there is a postdialysis gain in cerebral water linked to the intermittent treatment. CT may represent a simple reliable method for studying uremic encephalopathy and investigating the pathogenesis of the dialysis disequilibrium syndrome.

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“…Moreover the routine EEG in 2 of these 3 patients, both with a history of seizures, showed a photoconvulsive response. The possibility that patients with uremia can develop epileptiform abnormalities and even seizures, as well as a heightened sensitivity to photic stimulation, has long been known [17]. The experimen tal inhibition of the photoconvulsive response in epilep tics by apomorphine, a dopamine receptor agonist, sug gests that this response is related to decreased brain lev els of the neurotransmitter dopamine [18].…”

Section: Discussionmentioning

confidence: 99%

Long-Term EEG Monitoring in Uremic Children on Chronic Dialysis Treatment

Fusco

Picca²,

Rizzoni

et al. 1991

Eur Neurol

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Even in the absence of clinically apparent seizures, patients undergoing chronic dialysis often exhibit abnormal EEG activity, which is usually attributed to the type of dialysis or to the dysequilibrium syndrome. To find out whether these abnormalities occurred only during dialysis sessions, 10 children with end-stage renal failure undergoing chronic dialysis were continuously monitored for 52 h during dialysis and between two sessions. The EEG tracing was abnormal in 5 children. Two had paroxysmal aspecific slow waves towards the end of the sessions, with a fall in blood pressure, malaise and fainting. In 3 children EEG abnormalities – also present in the interdialytic period – were not clinically apparent. Long-term EEG monitoring in these cases distinguished between the electrical events that were related to dialysis and those that were not. It also suggested that, rather than being dialysis-dependent, these events frequently reflect a basic neurological disorder.

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Neurological complications of dialysis, transplantation, and other forms of treatment in chronic uremia

Cited by 67 publications

References 0 publications

Relationship of nervous tissue transketolase to the neuropathy in chronic uremia

Relationship of nervous tissue transketolase to the neuropathy in chronic uremia

Studies on Brain Density in Hemodialysis and Peritoneal Dialysis

Long-Term EEG Monitoring in Uremic Children on Chronic Dialysis Treatment

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