Neurological and Cognitive Significance of Probiotics: A Holy Grail Deciding Individual Personality

Afzal, Muhammad; Mazhar, Sayyeda Farwa; Sana, Sadia; Naeem, Muhammad; Rasool, Muhammad Hidayat; Saqalein, Muhammad; Nisar, Muhammad Atif; Rasool, Maria; Bilal, Muhammad; Khan, Abdul Arif; Khurshid, Mohsin

doi:10.2217/fmb-2019-0143

Cited by 16 publications

(11 citation statements)

References 121 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Physiologically, microbiota affects amygdala maturation in mammals, and baseline neuronal activity in the amygdala is altered in germ-free animals, leading to neurodevelopmental disorders ( Stilling et al, 2015 ). Among the factors associated with the field of neuroscience pathology, the gut microbiota can affect a broad range of host neuroscience disorders by interacting with the host through immune, metabolic, neural, and endocrine pathways ( Afzal et al, 2020 ). In recent decades, the relationships between the gastrointestinal microbiome and neuroscience in animals and humans have been widely studied.…”

Section: Introductionmentioning

confidence: 99%

Mapping trends and hotspot regarding gastrointestinal microbiome and neuroscience: A bibliometric analysis of global research (2002–2022)

et al. 2022

View full text Add to dashboard Cite

BackgroundScholars have long understood that gastrointestinal microorganisms are intimately related to human disorders. The literature on research involving the gut microbiome and neuroscience is emerging. This study exposed the connections between gut microbiota and neuroscience methodically and intuitively using bibliometrics and visualization. This study’s objectives were to summarize the knowledge structure and identify emerging trends and potential hotspots in this field.Materials and methodsOn October 18, 2022, a literature search was conducted utilizing the Web of Science Core Collection (WoSCC) database for studies on gut microbiota and neuroscience studies from 2002 to 2022 (August 20, 2022). VOSviewer and CiteSpace V software was used to conduct the bibliometrics and visualization analysis.ResultsFrom 2002 to 2022 (August 20, 2022), 2,275 publications in the WoSCC database satisfied the criteria. The annual volume of publications has rapidly emerged in recent years (2016–2022). The most productive nation (n = 732, 32.18%) and the hub of inter-country cooperation (links: 38) were the United States. University College Cork had the most research papers published in this area, followed by McMaster University and Harvard Medical School. Cryan JF, Dinan TG, and Clarke G were key researchers with considerable academic influence. The journals with the most publications are “Neurogastroenterology and Motility” and “Brain Behavior and Immunity.” The most cited article and co-cited reference was Cryan JF’s 2012 article on the impact of gut microbiota on the brain and behavior. The current research hotspot includes gastrointestinal microbiome, inflammation, gut-brain axis, Parkinson’s disease (PD), and Alzheimer’s disease (AD). The research focus would be on the “gastrointestinal microbiome, inflammation: a link between obesity, insulin resistance, and cognition” and “the role of two important theories of the gut-brain axis and microbial-gut-brain axis in diseases.” Burst detection analysis showed that schizophrenia, pathology, and psychiatric disorder may continue to be the research frontiers.ConclusionResearch on “gastrointestinal microbiome, inflammation: a link between obesity, insulin resistance, and cognition” and “the role of two important theories of the gut-brain axis and microbial-gut-brain axis in diseases” will continue to be the hotspot. Schizophrenia and psychiatric disorder will be the key research diseases in the field of gut microbiota and neuroscience, and pathology is the key research content, which is worthy of scholars’ attention.

show abstract

Section: Introductionmentioning

confidence: 99%

Mapping trends and hotspot regarding gastrointestinal microbiome and neuroscience: A bibliometric analysis of global research (2002–2022)

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Several factors such as diet, gender, age, and race affect the composition as well as the function of microbiota [19]. After birth, the host is colonized by the simple community of bacteria, furthermore during the growth of the host development of microbiota occurs gradually [20][21][22]. Over time host and bacterial association results in many useful functions, such as symbiosis, bacteria help in intestinal function, preventing the colonization of harmful bacteria, and the digestion of some compounds [18,23].…”

Section: Human Microbiota In Healthmentioning

confidence: 99%

Potential Role of Microbiota in the Prevention and Therapeutic Management of Infectious Diseases

Shahid¹,

Nasir²,

Aslam³

et al. 2022

PJBB

Self Cite

View full text Add to dashboard Cite

A huge diversity of microbial species continues to live with the human beings that are collectively known as microbiota. Several environmental factors can impact the microbial imbalance in the intestine which can play a starring role in health and disease conditions in humans. In this review, we have described the role of human microbiota in the individual’s susceptibility to infectious diseases such as gastrointestinal, respiratory, and female reproductive tract infections. Here, we have discussed how the indigenous microbiota interacts with the host and the invader microorganisms including bacteria, fungi, and viruses, and can modify the outcome of infections. The complex mechanisms of colonization resistance mediated by the microbiota as a direct and indirect way to fight against the infectious agents have been highlighted. Moreover, the approaches for the modulation of human microbiota for the prevention or therapeutic management of infectious diseases have been discussed especially the potential therapies directly targeting the microbiota such as probiotics, prebiotics, as well as fecal microbiota transplantation. Further studies need to focus on the complex interactions between the host and microbial species which could be helpful for a better understanding of the hidden potential of gut microbiota in the physiology of the host and could provide novel therapeutic targets and approaches.

show abstract

“…Probiotics are represented as the most widely used dietary supplements. Though, the role of probiotics in shaping the human gut microbiome is not yet conclusive ( Khurshid et al, 2015 ; Afzal et al, 2020 ; Khurshid and Akash, 2020 ; Paray et al, 2020 ). In most studies, the genus Lactobacillus was used to ameliorate obesity in rodents which lead to various metabolic benefits such as reduction in body fat and adipocyte cell size, and control of unnecessary body weight gain ( Luoto et al, 2010 ; Takemura et al, 2010 ).…”

Section: Diversity Of Gut Microbiome Across the Populationmentioning

confidence: 99%

Personalized nutrition, microbiota, and metabolism: A triad for eudaimonia

Sarfraz

Shahid²,

Asghar³

et al. 2022

Front. Mol. Biosci.

Self Cite

View full text Add to dashboard Cite

During the previous few years, the relationship between the gut microbiota, metabolic disorders, and diet has come to light, especially due to the understanding of the mechanisms that particularly link the gut microbiota with obesity in animal models and clinical trials. Research has led to the understanding that the responses of individuals to dietary inputs vary remarkably therefore no single diet can be suggested to every individual. The variations are attributed to differences in the microbiome and host characteristics. In general, it is believed that the immanent nature of host-derived factors makes them difficult to modulate. However, diet can more easily shape the microbiome, potentially influencing human physiology through modulation of digestion, absorption, mucosal immune response, and the availability of bioactive compounds. Thus, diet could be useful to influence the physiology of the host, as well as to ameliorate various disorders. In the present study, we have described recent developments in understanding the disparities of gut microbiota populations between individuals and the primary role of diet-microbiota interactions in modulating human physiology. A deeper understanding of these relationships can be useful for proposing personalized nutrition strategies and nutrition-based therapeutic interventions to improve human health.

show abstract

Neurological and Cognitive Significance of Probiotics: A Holy Grail Deciding Individual Personality

Cited by 16 publications

References 121 publications

Mapping trends and hotspot regarding gastrointestinal microbiome and neuroscience: A bibliometric analysis of global research (2002–2022)

Mapping trends and hotspot regarding gastrointestinal microbiome and neuroscience: A bibliometric analysis of global research (2002–2022)

Potential Role of Microbiota in the Prevention and Therapeutic Management of Infectious Diseases

Personalized nutrition, microbiota, and metabolism: A triad for eudaimonia

Contact Info

Product

Resources

About