Neurological and cerebellar soft signs do not discriminate schizophrenia from bipolar disorder patients

Chrobak, Adrian Andrzej; Siwek, Grzegorz Przemysław; Siuda‐Krzywicka, Katarzyna; Arciszewska, Aleksandra; Starowicz-Filip, Anna; Siwek, Marcin; Dudek, Dominika

doi:10.1016/j.pnpbp.2015.07.009

Cited by 38 publications

(17 citation statements)

References 41 publications

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“…Though neurological soft signs are most frequently associated with schizophrenia, NSS are also common in BP (88, 89). We do not have behavioral data about NSS in our sample to determine whether our observation of abnormal somatomotor cerebro-cerebellar FC is associated with NSS, and this may be a valuable subject for future studies.…”

Section: Discussionmentioning

confidence: 99%

Aberrant Cerebellar Connectivity in Bipolar Disorder With Psychosis

Shinn

Roh²,

Ravichandran

et al. 2017

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Background The cerebellum, which modulates affect and cognition in addition to motor functions, may contribute substantially to the pathophysiology of mood and psychotic disorders, such as bipolar disorder. A growing literature points to cerebellar abnormalities in bipolar disorder. However, no studies have investigated the topographic representations of resting state cerebellar networks in bipolar disorder, specifically their functional connectivity to cerebral cortical networks. Methods Using a well-defined cerebral cortical parcellation scheme as functional connectivity seeds, we compared ten cerebellar resting state networks in 49 patients with bipolar disorder and a lifetime history of psychotic features and 55 healthy control participants matched for age, sex, and image signal-to-noise ratio. Results Patients with psychotic bipolar disorder showed reduced cerebro-cerebellar functional connectivity in somatomotor A, ventral attention, salience, and frontoparietal control A and B networks relative to healthy control participants. These findings were not significantly correlated with current symptoms. Conclusions Patients with psychotic bipolar disorder showed evidence of cerebro-cerebellar dysconnectivity in selective networks. These disease-related changes were substantial and not explained by medication exposure or substance use. Therefore, they may be mechanistically relevant to the underlying susceptibility to mood dysregulation and psychosis. Cerebellar mechanisms deserve further exploration in psychiatric conditions, and this study’s findings may have value in guiding future studies on pathophysiology and treatment of mood and psychotic disorders, in particular.

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Section: Discussionmentioning

confidence: 99%

Aberrant Cerebellar Connectivity in Bipolar Disorder With Psychosis

Shinn

Roh²,

Ravichandran

et al. 2017

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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“…MA have been less studied in bipolar disorder. However, a wide amount of research has highlighted the commonalities between schizophrenia spectrum disorders and bipolar disorder [ 15 – 19 ]. Both disorders share genetic liability and some clinical features [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Handwriting movements for assessment of motor symptoms in schizophrenia spectrum disorders and bipolar disorder

et al. 2019

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The main aim of the present study was to explore the value of several measures of handwriting in the study of motor abnormalities in patients with bipolar or psychotic disorders. 54 adult participants with a schizophrenia spectrum disorder or bipolar disorder and 44 matched healthy controls, participated in the study. Participants were asked to copy a handwriting pattern consisting of four loops, with an inking pen on a digitizing tablet. We collected a number of classical, non-linear and geometrical measures of handwriting. The handwriting of patients was characterized by a significant decrease in velocity and acceleration and an increase in the length, disfluency and pressure with respect to controls. Concerning non-linear measures, we found significant differences between patients and controls in the Sample Entropy of velocity and pressure, Lempel-Ziv of velocity and pressure, and Higuchi Fractal Dimension of pressure. Finally, Lacunarity, a measure of geometrical heterogeneity, was significantly greater in handwriting patterns from patients than from controls. We did not find differences in any handwriting measure on function of the specific diagnosis or the antipsychotic dose. Results indicate that participants with a schizophrenia spectrum disorder or bipolar disorder exhibit significant motor impairments and that these impairments can be readily quantified using measures of handwriting movements. Besides, they suggest that motor abnormalities are a core feature of several mental disorders and they seem to be unrelated to the pharmacological treatment.

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“…NSS comprise a broad range of subtle neurological deficits such as discrete impairments in sensory integration, motor coordination, balance, sequencing of complex motor acts, overflow movements, and occasionally clumsiness and occurrence of primitive reflexes [Schroder et al, 1991]. From a clinical standpoint, NSS are strongly associated with schizophrenia [Bernard and Mittal, 2015;Hirjak et al, 2015a], autism [Hirjak et al, 2014[Hirjak et al, , 2016c, ADHD [D'Agati et al, 2010;Pitzianti et al, 2016], bipolar disorders [Chrobak et al, 2016], and TS [Semerci, 2000]. More recent research has started to explore NSS brain correlates in autism [Hirjak et al, 2016c] and ADHD [D'Agati et al, 2010] suggesting dysfunctional dopaminergic circuits in cortical and basal ganglia structures.…”

Section: Introductionmentioning

confidence: 99%