Neurological abnormalities in schizophrenic patients: a prospective follow‐up study 5 years after first admission

Madsen, A.; Vorstrup, Sissel; Rubin, P.; Larsen, Jens Knud; Hemmingsen, Ralf

doi:10.1111/j.1600-0447.1999.tb10832.x

Cited by 69 publications

(70 citation statements)

References 23 publications

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“…A number of crosssectional studies did not find an association between neurological soft signs and illness length (e.g., Gupta et al, 1995;Ismail, Cantor-Graae, Cardenal, & McKeil, 1998;Venkatasubramanian et al, 2003;Chen, Lam, Chen, & Nguyen, 1996). However, Yazici, Demir, Yazici, and Gogus (2002) Madsen, Vorstrup, Rubin, and Larsen (1999) found a higher incidence of neurological abnormalities over a five-year period. Given that patients with unremitting symptoms also received higher or more continuous doses of medication, it is difficult to disentangle the effects of symptom course and severity from the consequences of medication (Bombin et al, 2005).…”

Section: Neurological Soft Signs and Schizophreniamentioning

confidence: 97%

Neurological Soft Signs in Psychometrically Identified Schizotypy

Kaczorowski

Barrantes‐Vidal

Kwapil

2010

Schizophrenia Research

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Patients with schizophrenia often exhibit structural brain abnormalities, as well as neurological soft signs, consistent with its conceptualization as a neurodevelopmental disorder. Neurological soft signs are mild, presumably nonlocalizing, neurological impairments that are inferred from performance deficits in domains such as sensory integration, motor coordination, and motor sequencing. The vulnerability for schizophrenia is presumed to be expressed across a broad continuum of impairment referred to as schizotypy. It is hypothesized that nondisordered people along the schizotypy continuum should exhibit elevated rates of neurological soft signs. The present study examined the relation of psychometrically identified positive and negative schizotypy with neurological soft signs using the Neurological Evaluation Scale (NES) in a nonclinically ascertained sample of young adults (n = 177). As hypothesized, negative, but not positive, schizotypy was related to increased neurological soft signs in tasks that assessed fine and gross motor coordination, motor sequencing, eye movement abnormalities, and memory recall. However, positive schizotypy was associated with increased neurological soft signs in tasks related to sensory integration dysfunction. In general, the positive x negative schizotypy interaction term was unrelated to individual neurological soft sign tasks. The findings support: a) the theory that the vulnerability for schizophrenia is expressed across a broad continuum of subclinical and clinical impairment referred to as schizotypy; b) the multidimensional structure of schizotypy; and c) the notion that schizotypy is an appropriate construct for understanding the etiology and development of schizophrenia-spectrum disorders. NEUROLOGICAL SOFT SIGNS IN PSYCHOMETRICALLY IDENTIFIEDSCHIZOTYPY by

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Section: Neurological Soft Signs and Schizophreniamentioning

confidence: 97%

Neurological Soft Signs in Psychometrically Identified Schizotypy

Kaczorowski

Barrantes‐Vidal

Kwapil

2010

Schizophrenia Research

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“…NSS are minor ("soft") neurological abnormalities in sensory and motor performance identified by clinical examination. In a follow-up study by Madsen et al 36 , a significant increase in the number of neurological abnormalities was observed in a group of males five years after the onset of the first psychotic episode. Nevertheless, results from studies with schizophrenia patients were not consistent with respect to the differences in gender and NSS.…”

Section: Premorbid and Prodromic Variablesmentioning

confidence: 99%

“…Studies in patients with a first psychotic episode have shown a possible relationship between the presence of Neurological Soft Signs (NSS) and the male gender 36 . NSS are minor ("soft") neurological abnormalities in sensory and motor performance identified by clinical examination.…”

Section: Premorbid and Prodromic Variablesmentioning

confidence: 99%

Gender differences in incipient psychosis

et al. 2010

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-Background and Objectives: To describe gender differences in a group of patients with first-episode psychotic in different aspects: socio-demographic features, characteristics of the phases prior to disease onset (premorbid and prodromic periods), clinical manifestation of psychotic symptoms and possible corresponding cognitive alterations after disease onset, using the age at onset of first psychotic episode as a control variable.Methods: Longitudinal study of 53 consecutive cases with a first psychotic episode. Inclusion criteria: two or more psychotic symptoms; age between 7 to 65 years old; first consultation to the medical center of study; less than 6 months since the first contact to the medical service; and less than a year of symptoms' evolution. The methodologic assess- GENDER DIFFERENCES IN INCIPIENT PSYCHOSIS 177

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“…A large number of studies now suggest that these signs are already present at the time of the first psychotic episode [4,[10][11][12][13], although the mean scores may be even higher in subjects at more advanced stages of the illness [14], where worse neurological dysfunction could be a consequence of the progression of the disease. Although significantly lower than those of patients, NSS are also present in healthy individuals from the general population, with rates varying from 5% [15,16] to more than 50% [17,18], the proportion reported being mainly a function of the measure used.…”

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confidence: 99%