Neurologic Manifestations of Lyme Disease

Halperin, John

doi:10.1007/978-1-4613-9698-7_21

Cited by 8 publications

(11 citation statements)

References 36 publications

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“…48,[52][53][54] Very rarely, MR imaging has documented reversal of LNB encephalitis subsequent to antibiotic management. 49,55 The imaging resolution, however, lagged years behind the rapid clinical response to intravenous antibiotics.…”

Section: Cns Lnbmentioning

confidence: 99%

Lyme Neuroborreliosis: Manifestations of a Rapidly Emerging Zoonosis

Hildenbrand¹,

Craven²,

Jones³

et al. 2009

AJNR Am J Neuroradiol

166

118

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SUMMARY:Lyme disease has a worldwide distribution and is the most common vector-borne disease in the United States. Incidence, clinical manifestations, and presentations vary by geography, season, and recreational habits. Lyme neuroborreliosis (LNB) is neurologic involvement secondary to systemic infection by the spirochete Borrelia burgdorferi in the United States and by Borrelia garinii or Borrelia afzelii species in Europe. Enhanced awareness of the clinical presentation of Lyme disease allows inclusion of LNB in the imaging differential diagnosis of facial neuritis, multiple enhancing cranial nerves, enhancing noncompressive radiculitis, and pediatric leptomeningitis with white matter hyperintensities on MR imaging. The MR imaging white matter appearance of successfully treated LNB and multiple sclerosis display sufficient similarity to suggest a common autoimmune pathogenesis for both. This review highlights differences in the epidemiology, clinical manifestations, diagnosis, and management of Lyme disease in the United States, Europe, and Asia, with an emphasis on neurologic manifestations and neuroimaging.

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Section: Cns Lnbmentioning

confidence: 99%

Lyme Neuroborreliosis: Manifestations of a Rapidly Emerging Zoonosis

Hildenbrand¹,

Craven²,

Jones³

et al. 2009

AJNR Am J Neuroradiol

166

118

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“…NB appears in 10-15% of LB patients (Halperin, 2011) and the clinical course is highly variable and may manifest as meningitis, facial palsy, cranial neuritis and radiculitis. In a Swedish study, facial palsy, neck pain, fever and fatigue were more common in patients under the age of 40 years, whereas unspecific muscle and joint pain, radiating pain, paresthesias, vertigo, and concentration difficulties were more common in patients over the age of 40 years (Henningsson et al, 2010).…”

Section: Neuroborreliosismentioning

confidence: 99%

A STING from a Tick : Epidemiology, Ecology and Clinical Aspects of Lyme Borreliosis

Wilhelmsson¹

2014

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“…Late (symptom duration >6 months) or severe disease, particularly with cardiac or neurological involvement, requires a longer course of intravenous antibiotics. For late NB or rare cases of encephalitis or vasculitis, the recommendations are ceftriaxone (2 g once daily) or cefotaxime (2 g three times a day) for 3 weeks 50. With cardiac involvement, oral doxycycline is appropriate with intravenous antibiotics reserved for cases requiring temporary pacing.…”

Section: Treatment Of Lyme Diseasementioning

confidence: 99%

Lyme disease in the United Kingdom

Dubrey

Bhatia

Woodham

et al. 2013

Postgraduate Medical Journal

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Lyme disease, while still an uncommon disease in the UK, is on the increase. Case numbers have increased by 3.6-fold since 2001, with over 950 cases reported by the Health Protection Agency (HPA) in 2011, compared with less than 500 cases annually pre-2004. HPA indications of the true incidence are suggested to be closer to 3000 cases/year, of which around 82% of cases are indigenously acquired. Three genospecies, Borrelia burgdorferi sensu stricto, Borrelia afzelli and Borrelia garinii, represent the predominant pathogenic variants in the UK. Erythema migrans is the commonest manifestation, occurring in 60%-91% of cases. In the UK, neuroborelliosis is the most common complication, while myocarditis is unusual, and death from either conduction disease or carditis is extremely rare. The role of Borrelia infection in chronic dilated cardiomyopathy in the UK remains unproven. Controversy over the existence of either 'chronic Lyme disease' and/or 'post-Lyme disease syndrome' continues unabated. National medical societies, patient advocacy groups, insurance companies, lawyers, doctors, the private health medical sector and scientific journals have all become embroiled in this bitter controversy. New developments include diagnostic tests able to detect Lyme disease at an earlier stage, shorter durations of antibiotic therapy and potential advances in vaccines against Borrelia.

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Neurologic Manifestations of Lyme Disease

Cited by 8 publications

References 36 publications

Lyme Neuroborreliosis: Manifestations of a Rapidly Emerging Zoonosis

Lyme Neuroborreliosis: Manifestations of a Rapidly Emerging Zoonosis

A STING from a Tick : Epidemiology, Ecology and Clinical Aspects of Lyme Borreliosis

Lyme disease in the United Kingdom

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