Neurologic Impairment 10 Years After Optic Neuritis

Rw, Beck; Ch, Smith; Rl, Gal; Xing, Dongyuan; Mt, Bhatti; Mc, Brodsky; Eg, Buckley; Ga, Chrousos; Corbett, James J.; Eggenberger, Eric; Ja, Goodwin; Katz, Barrett; Di, Kaufman; Jl, Keltner; Mj, Kupersmith; Nr, Miller; Ps, Moke; Nazarian, Sarkis M.; Orengo-Nania, Silvia; Pj, Savino; Wt, Shults; Jd, Trobe; Wall, Michael

doi:10.1001/archneur.61.9.1386

Cited by 68 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their findings suggest that the existence and number of lesions observed at baseline brain MRI may serve as predictive factors for disability in MS-related optic neuritis cases. However, Beck et al ( 44 ) found that, in the ONTT cohort, there was no significant correlation between the level of disability after 10 years and the presence or number of lesions in the initial brain MRI scans. The discordance observed between these studies that focus on clinically isolated syndrome and the conclusions of Beck et al’s study may stem from a variety of factors.…”

Section: Discussionmentioning

confidence: 96%

Development of a predictive model for predicting disability after optic neuritis: a secondary analysis of the Optic Neuritis Treatment Trial

Wei,

Du,

Luo

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

ObjectiveThe present study aimed to develop a prediction model for predicting developing debilities after optic neuritis.MethodsThe data for this research was obtained from the Optic Neuritis Treatment Trial (ONTT). The predictive model was built based on a Cox proportional hazards regression model. Model performance was assessed using Harrell’s C-index for discrimination, calibration plots for calibration, and stratification of patients into low-risk and high-risk groups for utility evaluation.ResultsA total of 416 patients participated. Among them, 101 patients (24.3%) experienced disability, which was defined as achieving or surpassing a score of 3 on the expanded disability status scale. The median follow-up duration was 15.5 years (interquartile range, 7.0 to 16.8). Two predictors in the final predictive model included the classification of multiple sclerosis at baseline and the condition of the optic disk in the affected eye at baseline. Upon incorporating these two factors into the model, the model’s C-index stood at 0.71 (95% CI, 0.66–0.76, with an optimism of 0.005) with a favorable alignment with the calibration curve. By utilizing this model, the ONTT cohort can be categorized into two risk categories, each having distinct rates of disability development within a 15-year timeframe (high-risk group, 41% [95% CI, 31–49%] and low-risk group, 13% [95% CI, 8.4–17%]; log-rank p-value of <0.001).ConclusionThis predictive model has the potential to assist physicians in identifying individuals at a heightened risk of experiencing disability following optic neuritis, enabling timely intervention and treatment.

show abstract

Section: Discussionmentioning

confidence: 96%

Development of a predictive model for predicting disability after optic neuritis: a secondary analysis of the Optic Neuritis Treatment Trial

Wei,

Du,

Luo

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…A gradual recovery of visual acuity with time is characteristic of ON. [ 32 ] For most patients, even without treatment, visual function improves from 1 week to several weeks after onset. In the Optic Neuritis Treatment Trial (ONTT) study, intravenous steroids improved the vision faster as compared to those treated with oral steroids or placebo.…”

Section: Demyelinationmentioning

confidence: 99%

Magnetic resonance imaging of optic nerve

Gala

2015

Indian Journal of Radiology and Imaging

View full text Add to dashboard Cite

Optic nerves are the second pair of cranial nerves and are unique as they represent an extension of the central nervous system. Apart from clinical and ophthalmoscopic evaluation, imaging, especially magnetic resonance imaging (MRI), plays an important role in the complete evaluation of optic nerve and the entire visual pathway. In this pictorial essay, the authors describe segmental anatomy of the optic nerve and review the imaging findings of various conditions affecting the optic nerves. MRI allows excellent depiction of the intricate anatomy of optic nerves due to its excellent soft tissue contrast without exposure to ionizing radiation, better delineation of the entire visual pathway, and accurate evaluation of associated intracranial pathologies.

show abstract

Optic Neuritis and Multiple Sclerosis: Long-term Prognostic Considerations

Kattah¹

2005

Arch Neurol

View full text Add to dashboard Cite

Neurologic Impairment 10 Years After Optic Neuritis

Cited by 68 publications

References 14 publications

Development of a predictive model for predicting disability after optic neuritis: a secondary analysis of the Optic Neuritis Treatment Trial

Development of a predictive model for predicting disability after optic neuritis: a secondary analysis of the Optic Neuritis Treatment Trial

Magnetic resonance imaging of optic nerve

Optic Neuritis and Multiple Sclerosis: Long-term Prognostic Considerations

Contact Info

Product

Resources

About