Neurologic Disease in Human Immunodeficiency Virus-Infected Drug Abusers

Malouf, Renee; Jacquette, Germaine; Dobkin, Jay F.; Brust, John C.M.

doi:10.1001/archneur.1990.00530090076016

Cited by 20 publications

(2 citation statements)

References 30 publications

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“…Fourteen studies included 30 or more women but did not analyze the data by sex. In 10 of these studies (Chiesi et al, 1996; Dooneief et al, 1992; Grassi et al, 1995; Malouf, Jacquette, Dobkin, & Brust, 1990; Moglia et al, 1991; Pinto, Grippo, Ghidini, Mazzotta, & Di Pietro, 1992; Ronchi et al, 1992; Royal et al, 1991; Silberstein et al, 1993; Strittmater, Lang, Wiestler, & Kleihues, 1992), all or most of the women reported intravenous drug use as the primary risk factor for HIV.…”

Section: Resultsmentioning

confidence: 99%

Potential Sex Differences Remain Understudied: A Case Study of the Inclusion of Women in HIV/AIDS-Related Neuropsychological Research

Fox-Tierney

Ickovics

Cerreta

et al. 1999

Review of General Psychology

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As an illustration of women's representation in clinical research, a comprehensive literature review of HIV/AIDS-related neuropsychological research was conducted. The goals of this study were to document whether women have been included in (a) HIV-related neurological and neuropsychological research studies; (b) percentages comparable to their representation in the population of persons with HIV/AIDS; (c) studies using numbers sufficient to allow data analyses by sex (N ≥ 30); and (d) data analyses conducted to examine sex differences. Women were included in half of the studies investigating neurological and neuropsychological manifestations of HIV between 1988 and 1997 (236 studies). However, their representation was inadequate to determine whether there were reliable sex differences in these complications. It is not simply enough to include more women; researchers must also strive to increase the quality of studies to ensure that women's contribution is clinically and empirically relevant.

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Section: Resultsmentioning

confidence: 99%

Potential Sex Differences Remain Understudied: A Case Study of the Inclusion of Women in HIV/AIDS-Related Neuropsychological Research

Fox-Tierney

Ickovics

Cerreta

et al. 1999

Review of General Psychology

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“…Bei den mit AIDS assoziierten zentralnervösen Störungen handelte es sich einerseits um Tumoren des ZNS, Infektionen und vaskuläre Komplikationen, andererseits Erkrankungen, die ätiologisch nicht einzuordnen waren wie beispielsweise die aseptische Meningitis und die subaktue Enzephalitis, auch "AIDS-dementia-complex" genannt (18,26). 1990 wurden in einer prospektiven Studie bei 190 Patienten mit AIDS oder Lymphadenopathie in 91 % neurologische Erkrankungen vorwiegend des ZNS festgestellt, wobei das Augenmerk auf mentale Veränderungen gerichtet war (20). In Arbeiten, welche sich auf autoptische Befunde stützen, wurden bei AIDS-Patienten in 90 % subakute Enzephalitiden festgestellt (9).…”

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Lumboradikuläres Syndrom bei HIV-Infektion

1992

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Neurologic and Neuropsychological Manifestations of Human Immunodeficiency Virus Infection in Intravenous Drug Users Without Acquired Immunodeficiency Syndrome

Marder

Stern²,

Malouf³

et al. 1992

Arch Neurol

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\s=b\ We examined 99 human immunodeficiency virus (HIV)\p=m-\ negative and 122 HIV-positive intravenous drug users (IVDUs) without acquired immunodeficiency syndrome (AIDS) to determine whether HIV-positive IVDUs had more neurologic and neuropsychological impairment than their HIV-negative counterparts. Controlling for age, education, drug use, history of head injury, and interactions between head injury and HIV status and drug use, HIV-positive subjects had more extrapyramidal signs and frontal release signs. These findings persisted when asymptomatic HIVpositive subjects without systemic signs of infection and HIV-negative subjects were compared. Neurologic findings were more severe in those with more systemic illness. Among those reporting a history of head injury with loss of consciousness, neuropsychological performance was significantly worse in the HIV-positive subjects, and this increased with severity of illness. This was not true in the group without head injury, suggesting an interaction between history of head injury and the seropositive state. No relationship was noted between head injury and either drug use or HIV state. Therefore, subtle neurologic and neuropsychological abnormalities may precede clinical evidence of AIDS in IVDUs and may be more evident in those with head injury.

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Neurologic Disease in Human Immunodeficiency Virus-Infected Drug Abusers

Cited by 20 publications

References 30 publications

Potential Sex Differences Remain Understudied: A Case Study of the Inclusion of Women in HIV/AIDS-Related Neuropsychological Research

Potential Sex Differences Remain Understudied: A Case Study of the Inclusion of Women in HIV/AIDS-Related Neuropsychological Research

Lumboradikuläres Syndrom bei HIV-Infektion

Neurologic and Neuropsychological Manifestations of Human Immunodeficiency Virus Infection in Intravenous Drug Users Without Acquired Immunodeficiency Syndrome

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