Neurologic Conditions Occurring as Complications of Pregnancy

King, Arthur B.

doi:10.1001/archneurpsyc.1950.02310220078008

Cited by 43 publications

(9 citation statements)

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“…8 Others implicate the engorgement of the blood vessels that feed the tumor. 9 In our case, too, the brain neoplasm caused symptoms compatible with mild postanesthesia complications.…”

Section: Discussionsupporting

confidence: 47%

Olfactory Neuroblastoma as Acute Postpartum Depression

Dascalu

Chayen

Kaplan

et al. 1998

The Journal of the American Board of Family Medicine

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Olfactory neuroblastoma is a rare neuroectodermal malignant tumor. It was first described by Berger et al in 1924, I and about 250 cases have since been reported, none of them in the perinatal period. The tumor emerges from the olfactory membrane located in the sinonasal area and anterior cranial fossa. It has a broad histologic spectrum and can be confused with peripheral neuroectodermal tumors. Z Early symptoms are intranasal obstruction, epistaxis, and anosmia. 3 As the tumor grows, it can invade the oral cavity,4 the orbits, and the brain,3,5 In very rare cases the initial symptom is depression and frontal lobe dysfunction. 6 We describe a patient with olfactory neuroblastoma in whom the presenting symptom resembled postpartum depression. Case ReportThe patient, 40 years of age, gravida 3, para 4, first came to our clinic for prepregnancy consultation. All previous pregnancies and deliveries, the most recent 15 years ago, had been uneventful. She had a history of mild hypertension (140/90 mmHg), which from the 12th week of her last pregnancy was treated with methyldopa 250 mg twice a day.Results of her primary workup for hypertension performed by her family physician, which included kidney, adrenal, and liver function tests, were normal. In addition, she suffered from chronic sinusitis for which she received homeopathic therapy and antibiotics and nasal spray for acute exacerbations. She was observed by an otolaryngologist before and during pregnancy. Findings on a computerized tomographic (en scan of the brain for sinusitis performed within the previous year were normal. She was also mildly obese.Her intrauterine device was remo~ed at her re-

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“…8 Others implicate the engorgement of the blood vessels that feed the tumor. 9 In our case, too, the brain neoplasm caused symptoms compatible with mild postanesthesia complications.…”

Section: Discussionsupporting

confidence: 47%

Olfactory Neuroblastoma as Acute Postpartum Depression

Dascalu

Chayen

Kaplan

et al. 1998

The Journal of the American Board of Family Medicine

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“…6 Since then a few case reports and mini-series have related the aggravation of signs and symptoms to one of the following mechanisms: (a) fluid retention, vascular engorgement, and increased edema; (b) the presence of hormone receptors on tumor cells, leading to dramatic growth of the meningioma during pregnancy. [7][8][9][10][11][12][13][14][15][16][17] The clinical picture of headache, vomiting, or seizure can be confused with hyperemesis gravidarium early in pregnancy or with eclampsia late in pregnancy. However, the presence of an abnormal fundoscopic examination, visual impairment, focal seizures, and lateralizing neurological deficits should alert physicians to the possibility of an intracranial lesion and prompt further investigations with MRI to establish the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Management Strategy for Meningioma in Pregnancy: A Clinical Study

Kanaan¹,

Jallu²,

Kanaan³

2003

Skull Base

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We retrospectively studied 18 pregnant women from 600 cases of meningioma treated at this Institution between 1986 and 2001. The variables evaluated included clinical presentation; radiological findings; timing and extent of surgical resection; and an overview of gestational, clinical, and surgical outcomes. Visual impairment was the chief complaint followed by headache and seizures. The tumors involved the tuberculum sella (8), sphenoid wing (4), convexity (2), parasellar (2), cerebellopontine angle (CPA) (1), and anterior falx (1). Gross total resection was achieved in 14, and subtotal resection was achieved in two patients. There were no related fetal or maternal deaths. Of seven patients with advanced or progressive visual impairment who underwent resection during pregnancy, three improved noticeably, two worsened, and two were unchanged. Five other patients with visual disturbance achieved full-term spontaneous delivery with improved vision in two and improved vision after post-confinement surgery in one. Vision remained unchanged in two. Intracranial meningioma during pregnancy challenges the skill of obstetricians and neurosurgeons to secure delivery of the baby and resection of the tumor. Advances in fetal and maternal monitoring, neuroanesthesia, and microsurgical techniques allow safe neurosurgical management of these patients, and pregnancy usually continues successfully to term. Surgical intervention has no major effect on minimal residual vision or advanced optic nerve atrophy.

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“…4,5) Several potential mechanisms for this phenomenon are being discussed. King et al 6) suggest that engorgement of blood vessels may increase growth of intracranial tumors in pregnant women. Weyand 7) proposes that it is due to an increase in intracellular fluid.…”

Section: Discussionmentioning

confidence: 99%

Chondroma of the Sternum Growing in a Pregnant Patient: A Case Report

Braun¹,

Weichhardt²,

Uhlmann³

2017

ATCS

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Purpose: Benign tumors are known to grow or develop sometimes during pregnancy. We present a case report about a young woman with a growing sternal tumor. Methods: After her second pregnancy, a 32-year-old female presented with a rapid growing sternal tumor. Computed tomography (CT) scan revealed a tumor measuring 10 × 8 × 7 cm with an intrathoracic bulk, compressing the heart and the upper margin of the liver. Results: Resection of the tumor was performed uneventfully. Histologic examination of the resected mass revealed a chondroma. Conclusion: To the best of our knowledge, this is the first report of a huge sternal chondroma growing in a pregnant patient. There is not often a need to treat these patients before delivery, however, thereafter surgical treatment of growing tumors is recommended.

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Neurologic Conditions Occurring as Complications of Pregnancy

Abstract: Cole 51 stated that young adults are more susceptible to toxic effects of arsenical drugs than older persons and that women are more sensi-51. Cole, H. N., and others: Toxic Effects Following Use of Arsphenamine, J. A. M. A. 97:897 (Sept. 26) 1931.

Cited by 43 publications

References 1 publication

Olfactory Neuroblastoma as Acute Postpartum Depression

Olfactory Neuroblastoma as Acute Postpartum Depression

Management Strategy for Meningioma in Pregnancy: A Clinical Study

Chondroma of the Sternum Growing in a Pregnant Patient: A Case Report

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