Neurologic Complications of Lymphoma

Nayak, Lakshmi; Grommes, Christian

doi:10.1007/978-3-319-57901-6_31

Cited by 2 publications

(2 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The annual incidence of PCNSL in the United States is 7 in 1,000,000, representing approximately 4% of CNS tumours. Secondary involvement occurs primarily in aggressive B-cell lymphomas and is present in approximately 5% of cases [ 4 ] . Acquired or congenital immunodeficiency is the best-established risk factor, and the disease usually presents as a single tumour located mainly in the frontal lobes (20%–43%) and the basal nuclei (9%–13%) [ 5 ] .…”

Section: Discussionmentioning

confidence: 99%

Primary central nervous system lymphoma complicated by cerebral venous sinus thrombosis: a case report

Medeiros,

Sequeira,

Mendes

et al. 2023

European Journal of Case Reports in Internal Medicine

View full text Add to dashboard Cite

Central nervous system (CNS) lymphoma is a rare and aggressive primary neoplasm that comprises a small proportion of brain tumours and non-Hodgkin lymphomas. We present a case report of a 64-year-old woman with CNS lymphoma, who exhibited cognitive changes, weight loss and neurological symptoms. Imaging scans revealed multiple lesions in the brain and thrombosis in the venous sinuses. A diagnosis of diffuse large B-cell lymphoma of the CNS was confirmed through histological examination. The patient underwent treatment with corticosteroids and chemotherapy, but experienced clinical deterioration with thrombocytopenia and disease progression. Despite efforts to manage complications and provide targeted therapy, the patient passed away. Primary CNS lymphoma typically responds well to chemotherapy, and prognostic factors such as age and functional status play a significant role in patient outcomes. However, complications such as thromboembolism pose challenges during treatment due to the hypercoagulable state induced by chemotherapy agents. The pathophysiology of thromboembolic events in the context of malignancy remains uncertain but may involve direct tumour compression, vascular invasion and alterations in coagulation factors. The diagnostic process for CNS lymphoma can be complex, and the information obtained from cerebrospinal fluid analysis, including flow cytometry, may be limited in cases with low cell counts. Ongoing research exploring genetic tests and biomarkers shows promise for improving diagnostic accuracy in such cases. This case underscores the need for comprehensive management strategies that address both the neoplasm and its associated complications, to optimise patient outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary central nervous system lymphoma complicated by cerebral venous sinus thrombosis: a case report

Medeiros,

Sequeira,

Mendes

et al. 2023

European Journal of Case Reports in Internal Medicine

View full text Add to dashboard Cite

show abstract

“…The annual incidence of primary CNS lymphoma in the United States is seven in 1,000,000 representing approximately 4% of CNS tumors. Secondary involvement occurs primarily in aggressive B-Cell lymphomas and is present in approximately 5% of cases [ 5 ]. Gadolinium-enhanced MRI is the imaging modality of choice for CNS involvement of NHL [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Diffuse Large B-Cell Lymphoma Presenting as an Unusual Paraneoplastic Neurologic Syndrome Affecting the Central and Peripheral Nervous Systems

Sorrentino¹,

Kelkar²,

Dang³

2021

Cureus

View full text Add to dashboard Cite

A 68-year-old man presented with a two-week history of ascending, symmetric, sensory neuropathy concerning an acute inflammatory demyelinating polyneuropathy that briefly responded to intravenous immunoglobulin (IVIg) therapy. The initial workup was negative for acquired causes. After three months of poor response to standard therapies, he was hospitalized for severe disability, unintentional weight loss, and additional, unexplained neurologic symptoms including cerebellar ataxia, dysarthria, and muscle twitching. Positron emission tomography revealed hypermetabolism isolated to the bone marrow. Bone marrow biopsy confirmed the diagnosis of diffuse large B-cell lymphoma (DLBCL). Due to rapidly worsening performance status, plasmapheresis was initiated prior to treatment with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy. His symptoms initially improved following plasmapheresis and resolved with chemotherapy. One year following treatment, he remains in complete remission. This case describes a unique paraneoplastic neurologic syndrome involving the central and peripheral nervous system that responded well to plasmapheresis and systemic chemotherapy.

show abstract

Neurologic Complications of Lymphoma

Cited by 2 publications

References 89 publications

Primary central nervous system lymphoma complicated by cerebral venous sinus thrombosis: a case report

Primary central nervous system lymphoma complicated by cerebral venous sinus thrombosis: a case report

Diffuse Large B-Cell Lymphoma Presenting as an Unusual Paraneoplastic Neurologic Syndrome Affecting the Central and Peripheral Nervous Systems

Contact Info

Product

Resources

About