Neurologic Complications of Liver Transplantation

Vogt, David; Lederman, Richard J.; Carey, William D.; Broughan, Thomas A.

doi:10.1097/00007890-198806000-00011

Cited by 102 publications

(59 citation statements)

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“…5 The incidence of NCs after LT reported in the literature varies. [4][5][6][7][8][9][10] Published reports indicate that up to 43% of patients experience severe NCs after the procedure. 1 In our present study, NC frequency was within the limits of previously reported rates.…”

Section: Discussionmentioning

confidence: 99%

Neurologic Complications After Liver Transplant: Experience at a Single Center

Derle

Kibaroğlu²,

Öcal³

et al. 2015

Exp Clin Transplant

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Objectives: Neurologic complications occur frequently after liver transplants. Up to 43% of patients experience severe postsurgical neurologic complications. These complications are significantly associated with longer hospital stay, morbidity, and mortality. The aim of this retrospective study was to evaluate the type and incidence of neurologic complications after liver transplants in adult patients. Materials and Methods:We retrospectively evaluated the medical records of 176 adult patients who had undergone liver transplants between 1995 and 2013. We recorded the demographic data, type of neurologic complications, type, and level of immunosuppressive treatment, and cause of liver failure. Results: Our study sample consisted of 48 deceaseddonor liver transplants and 128 living-donor transplants (n = 176). Fifty-three of the patients (30.1%) were female. The age range of the total sample was 18 to 66 years (mean age, 43.1 ± 13.7 y). As immunosuppressive treatment, most patients received tacrolimus alone (52%) or tacrolimus combined with mycophenolate mofetil (33%). Neurologic complications occurred in 74 of the patients (42%). The most common neurologic complications were diffuse encephalopathy (22.2%) and seizure (14.2%). Other neurologic complications were posterior reversible encephalopathy (1.7%), peripheral neuropathy (1.7%), cerebrovascular disease (1.1%), and central nervous system infection (1.1%). Age, cause of liver failure, and type of transplant were not associated with occurrence of neurologic complications. Conclusions: There was a high incidence of neurologic complications after liver transplants. Diffuse encephalopathy and seizure were common complications. Physicians should be aware of the high risk of neurologic complications after liver transplants. Factors such as immunosuppressive toxicity and metabolic imbalance that predispose patients to neurologic complications after liver transplants should be evaluated immediately, and treatment of postoperative neurologic complications should be initiated as early as possible.

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Section: Discussionmentioning

confidence: 99%

Neurologic Complications After Liver Transplant: Experience at a Single Center

Derle

Kibaroğlu²,

Öcal³

et al. 2015

Exp Clin Transplant

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“…[112][113][114] The incidence of these complications is generally reported to be in the 25-75% range. 112,[115][116][117][118][119][120][121] As mentioned above, some of these "complications" may be attributable to unrecognized pre-existing neural deficits related to malnutrition.…”

Section: Nutrition and Cirrhosis B Emeur And Butterworthmentioning

confidence: 99%

Nutrition in the Management of Cirrhosis and its Neurological Complications

Bémeur

Butterworth

2014

Journal of Clinical and Experimental Hepatology

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“…Three patients with tremor, ataxia, confusion, amnesia, hyporeflexia, and weakness have been described; these symptoms resolved after CsA was discontinued [5]. Two patients were reported to have developed ataxia, weakness, and dysarthria followed by seizures and coma [90]. A single patient with cerebellar edema and secondary brainstem compression requiring decompressive craniotomy has been described [63].…”

Section: Overview Of Csa-associated Neurotoxicitymentioning

confidence: 99%

Neurotoxicity of calcineurin inhibitors: impact and clinical management

Bechstein¹

2000

Transplant Int

475

284

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Between 10 %-28 % of patients who receive the immunosuppressant cyclosporine (CsA) experience some form of neurotoxic adverse event. Both sensorial motoric functions may be adversely affected, and thus patients present with a wide range of neurological and psychiatrical disorders. Mild symptoms are common and include tremor, neuralgia, and peripheral neuropathy. Severe symptoms affect up to 5 % of patients and include psychoses, hallucinations, blindness, seizures, cerebellar ataxia, motoric weakness, or leukoencephalopathy.

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Neurologic Complications of Liver Transplantation

Cited by 102 publications

References 0 publications

Neurologic Complications After Liver Transplant: Experience at a Single Center

Neurologic Complications After Liver Transplant: Experience at a Single Center

Nutrition in the Management of Cirrhosis and its Neurological Complications

Neurotoxicity of calcineurin inhibitors: impact and clinical management

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