Neurologic Complications Caused by Epstein-Barr Virus in Pediatric Patients

Mazur‐Melewska, Katarzyna; Breńska, Iwona; Jończyk‐Potoczna, Katarzyna; Kemnitz, P.; Pieczonka-Ruszkowska, Ilona; Mania, Anna; Służewski, Wojciech; Figlerowicz, Magdalena

doi:10.1177/0883073815613563

Cited by 26 publications

(20 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A Danish study found that EBV infection is common in young children, and children under 3 years of age constitute the largest group of hospitalizations for acute EBV infection 5 . In a study conducted in Poland, age of infection occurred in two peaks, i) in children aged 1 to 5 years (62%), and ii) in teenagers (24.6%) 17 . In most developing countries nearly 70% of patients are seropositive for EBV by the age of 2 years 18 .…”

Section: Discussionmentioning

confidence: 99%

Increasing Epstein-Barr virus infection in Chinese children: A single institutional based retrospective study.

Devkota¹,

He²,

Liu³

et al. 2019

F1000Res

View full text Add to dashboard Cite

The Epstein-Barr virus (EBV) is a common virus in humans and the most common causative agent of Infectious Mononucleosis. EBV primary infection has recently risen in some countries and children below 2 years of age are highly susceptible. The clinical manifestations in children with EB virus infection involve multiple systems, causing severe illness, meaning attention should be paid during diagnosis and treatment. Objective: This single institution based retrospective study was carried out with the aim of estimating the overall prevalence of EBV infection and identifying high-risk age group among children. Methods: This study include total 253 patients under 15 years of age found to be positive for EBV DNA by serum PCR who were admitted to the Pediatrics Department of Renmin Hospital,(Shiyan, China) during a 4-year period from 2014 to 2017. Patients were divided into three groups; 0-<4years, 4-<6years and 6-<15years. We then calculated the percentage and prevalence of EBV DNA-positive cases. Results: The yearly EBV prevalence rate was 4.99 per 1000 admissions in 2014, 6.97 per 1000 admissions in 2015, 10.42 per 1000 admissions in 2016, and 12.16 per 1000 admissions in 2017. Out of 253 EBV-positive cases, those under 4 years had the highest rate of EBV infection (74.7%). The rate drops to 11.06% in the 4-6 years group, and was 14.22% in the 6-15 years group. Those between 6 months and 1 year are those at the highest risk. Conclusion: The rate of hospital admission of children due to EBV infection is increasing day by day. Children under 4 years of age are highly susceptible to infection and children of age between 6 months and 1 year are the high-risk group for EBV infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Increasing Epstein-Barr virus infection in Chinese children: A single institutional based retrospective study.

Devkota¹,

He²,

Liu³

et al. 2019

F1000Res

View full text Add to dashboard Cite

show abstract

“…Twenty-one (6%) of 216 children in the Encephalitis Registry at University of Toronto had positive EBV serology and/or positive PCR, and 48% presented with seizures ( 25 ). In a large Polish registry including 194 children diagnosed with EBV infection with positive serology, febrile seizures occurred in 3.1% of cases younger than 5 years ( 26 ). Seizures during the course of EBV neuroinfection have been described as generalized tonic-clonic ( 27 ), focal ( 28 ), convulsive ( 29 ), and nonconvulsive ( 30 ) status epilepticus, and myoclonic seizures ( 31 ).…”

Section: Introductionmentioning

confidence: 99%

Detection of HHV-6 and EBV and Cytokine Levels in Saliva From Children With Seizures: Results of a Multi-Center Cross-Sectional Study

et al. 2018

View full text Add to dashboard Cite

Background and Objective: One third of children with epilepsy are refractory to medications. Growing data support a role of common childhood infections with neurotropic viruses and inflammation in epileptogenesis. Our objective was to determine the frequency of Human Herpesvirus-6 (HHV-6) and Epstein-Barr Virus (EBV) infection and cytokine levels in saliva from children with seizures compared to healthy controls and to controls with a febrile illness without seizures.Methods: In this cross-sectional multi-center study, we collected saliva from 115 consecutive children with acute seizures (cases), 51 children with a fever and no seizures or underlying neurological disease (fever controls) and 46 healthy children (healthy controls). Specimens were analyzed by a novel droplet digital PCR for HHV-6 and EBV viral DNA and a bead-based immunoassay for neuroinflammatory cytokines.Results: Cases included febrile seizures (n = 30), acute seizures without (n = 53) and with fever (n = 4) in chronic epilepsy, new onset epilepsy (n = 13), febrile status epilepticus (n = 3), and first lifetime seizure (n = 12). HHV-6 DNA was found in 40% of cases vs. 37% fever controls and 35% healthy controls, with no statistically significant differences. EBV DNA was also detected with no differences in 17% cases, 16% fever controls, and 28% healthy controls. IL-8 and IL-1β were increased in saliva of 32 random samples from cases compared with 30 fever controls: IL-8 cases mean (SD): 1158.07 pg/mL (1427.41); controls 604.92 (754.04); p = 0.02. IL-1β 185.76 (230.57); controls 86.99 (187.39); p = 0.0002. IL-1β level correlated with HHV6 viral load (p = 0.007).Conclusion: Increase in inflammatory cytokines may play a role in the onset of acute seizures and saliva could represent an inexpensive and non-invasive method for detection of viral DNA and cytokines.

show abstract

“…In some cases, most commonly, in the presence of the trigger, EBV may be reactivated and cause other disorders including cancers and CNS disorders [51,52]. It has been reported that the rate of neurological complications in EBV infections was 7% [53][54][55][56]. In addition, cases of isolated CN lesions like unilateral or bilateral facial nerve lesions associated with Epstein-Barr virus infection [16], and CN IV lesion with bilateral acute retinal necrosis following HHV6 and EBV infection of the CNS [17] have been reported.…”

Section: Resultsmentioning

confidence: 99%

Cranial nerve III and/or VI function abnormalities associated with active herpesvirus infection: Clinical experience and literature review

Vasilyeva¹,

Zhdanova²,

Chopik³

et al. 2018

Oftalmol Zh

View full text Add to dashboard Cite

The field of oculomotor abnormalities (OMA) is of clinical and social importance. There is a group of OMA of unknown etiology. Purpose: To investigate the presence of DNA of herpesviruses venous blood of patients with OMA resulting from lesions of cranial nerves (CN) III and/or VI. Materials and Methods: Thirty-five patients with OMA of unknown etiology underwent examination. Whole venous blood samples were collected for detection of herpes simplex virus type 1/2 (HSV1/2), cytomegalovirus (CMV), Epstein Barr virus (EBV), human herpes virus 6 (HHV6), HHV7, varicella-zoster virus (VZV), and HHV8 DNA using polymerase chain reaction. Results: HHV7 was most common (16 patients; 45.7%), followed by EBV (5; 14.3%), HHV6 (2; 5.7%), HSV1/2 (1 patient) and CMV (1 patient). Eight patients (22.8%) were found to have two viruses. Of these, 6 had both EBV and HHV7, one had both EBV and HHV6, and one had both HHV6 and HHV7. In addition, 2 patients (5.7%) were found to have three viruses, EBV, HHV6, and HHV7. Conclusion: For patients with OMA of unknown etiology, the venous blood should be tested by PCR for herpesviruses.

show abstract

Neurologic Complications Caused by Epstein-Barr Virus in Pediatric Patients

Cited by 26 publications

References 21 publications

Increasing Epstein-Barr virus infection in Chinese children: A single institutional based retrospective study.

Increasing Epstein-Barr virus infection in Chinese children: A single institutional based retrospective study.

Detection of HHV-6 and EBV and Cytokine Levels in Saliva From Children With Seizures: Results of a Multi-Center Cross-Sectional Study

Cranial nerve III and/or VI function abnormalities associated with active herpesvirus infection: Clinical experience and literature review

Contact Info

Product

Resources

About