Neurologic Aspects of Inflammatory Bowel Disease

Lossos, Alexander; River, Yaron; Eliakim, Abraham R.; Steiner, Israel

doi:10.1212/wnl.45.3.416

Cited by 228 publications

(201 citation statements)

References 34 publications

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“…Our present results prospectively confirm the fact that peripheral neuropathy is the most consistently reported neurological condition in IBD patients 1,4,8,9,12,13,14 . However, even the subject of peripheral neuropathy in IBD patients has been challenged by a recent retrospective study with important methodological limitations 11 .…”

Section: Discussionsupporting

confidence: 88%

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A Case-Control study of the prevalence of neurological diseases in inflammatory bowel disease (IBD)

Gondim

Oliveira

Teles

et al. 2015

Arq. Neuro-Psiquiatr.

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Neurological diseases are common in inflammatory bowel disease (IBD) patients, but their exact prevalence is unknown. Method: We prospectively evaluated the presence of neurological disorders in 121 patients with IBD [51 with Crohn's disease (CD) and 70 with ulcerative colitis (UC)] and 50 controls (gastritis and dyspepsia) over 3 years. Results: Our standard neurological evaluation (that included electrodiagnostic testing) revealed that CD patients were 7.4 times more likely to develop large-fiber neuropathy than controls (p = 0.045), 7.1 times more likely to develop any type of neuromuscular condition (p = 0.001) and 5.1 times more likely to develop autonomic complaints (p = 0.027). UC patients were 5 times more likely to develop large-fiber neuropathy (p = 0.027) and 3.1 times more likely to develop any type of neuromuscular condition (p = 0.015). Conclusion: In summary, this is the first study to prospectively establish that both CD and UC patients are more prone to neuromuscular diseases than patients with gastritis and dyspepsia.Keywords: Chron's disease, inflammatory bowel disease, peripheral neuropathy, small fiber neuropathy, ulcerative colitis. RESUMO Doenças neurológicas são comuns em pacientes com doença inflamatória intestinal (DII), mas sua prevalência exata é desconhecida. Métodos: Nós estudamos prospectivamente a presença de distúrbios neurológicos em 121 pacientes com DII [51 com doença de Crohn (DC) e 70 com colite ulcerativa (RCU)] e 50 controles (gastrite e dispepsia) ao longo de 3 anos. Resultados: A avaliação neurológica padronizada (que incluiu testes eletrodiagnósticos) demonstrou que pacientes com DC foram 7,4 vezes mais propensos a desenvolver neuropatias de fibras grossas do que os controles (p = 0,045), 7,1 vezes mais propensos a desenvolver qualquer tipo de condição neuromuscular (p = 0,001) e 5,1 vezes mais propensos a desenvolver queixas autonômicas (p = 0,027). Pacientes com RCU foram 5 vezes mais propensos de desenvolver neuropatia de fibras grossas (p = 0,027) e 3,1 vezes mais propensos a desenvolver qualquer tipo de condição neuromuscular (p = 0,015). Conclusão: Em resumo, este é o primeiro estudo prospectivo a estabelecer que os pacientes tanto com DC quanto de RCU são mais propensos a doenças neuromusculares do que os pacientes com gastrite e dispepsia.Palavras-chave: doença de Crohn, doença inflamatória intestinal, neuropatia periférica, neuropatia de fibras grossas, colite ulcerativa.

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Section: Discussionsupporting

confidence: 88%

“…However, there are conflicting reports about the exact prevalence of those neurological conditions due to variable inclusion and disease-definition criteria employed by different retrospective series 5,6,7,8,9,10,11,12 .…”

mentioning

confidence: 99%

A Case-Control study of the prevalence of neurological diseases in inflammatory bowel disease (IBD)

Gondim

Oliveira

Teles

et al. 2015

Arq. Neuro-Psiquiatr.

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“…The global frequency of vasculitis associated with IBD is unknown, but it has been reported that such cases of vasculitis involving the CNS are rare [31]. Furthermore, this manifestation seems to be independent of the activity of the disease in the gastrointestinal tract [30,32]. A correct diagnosis of CNS vasculitis is essential, because it allows the initiation of the appropriate treatment and the prevention of signiicant neurological impairment.…”

Section: Venous and Arterial Thrombotic And Thromboembolic Manifestatmentioning

confidence: 99%

“…Lossos et al reported a prevalence of 1.9% in a cohort of 638 IBD patients, although the majority of these patients had a structural and/or metabolic cause that may lead to epileptic seizures [32]. Other authors have reported an improvement of seizures in CD patients after treatment initiation, suggesting that immunological mechanisms may be associated with the development of this disorder [43].…”

Section: Epilepsymentioning

confidence: 99%

Neurological Manifestations of Inflammatory Bowel Disease

Plata‐Bello¹,

Acosta-López²

2018

New Concepts in Inflammatory Bowel Disease

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The inlammatory bowel disease (IBD) is associated with diferent neurological and psychiatric disorders, which are integrated among the extra-intestinal manifestation of this disease. The physiopathology of neurological manifestations of IBD varies among the diferent kind of complications. The origin and the signiicance of these manifestations must be understood by clinicians who manage IBD patients. Some of them are related to therapeutic agents. The present chapter consists of a review of the most prevalent neurological and psychiatric disorders associated with IBD. The physiopathology of those entities will also be discussed, as well as the appropriate management for their prevention and treatment.

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“…Management of these patients including diagnosis and treatment is generally similar to patients without UC (Pandian, Pawar et al, 2004). O t h e r r a r e n e u r o l o g i c a l c o m p l i c a t i o n s o f U C t h a t h a v e b e e n r e p o r t e d i n c l u d e : a c u t e disseminated encephalomyelitis, optic neuritis, sensorineural hearing loss, myelopathy, peripheral polyneuropathy, Guillain-Barre syndrome, and myasthenia gravis (Gondim et al, 2005;Kanra et al, 2002;Krystallis et al, 2010;Lossos et al, 1995;Scheid & Teich, 2007;Tan, 1974;Yesilova et al, 2006). Many of these complications are autoimmune in nature and respond to steroids and/or immunosuppressive therapy.…”

Section: Immune Mediated Neuropathymentioning

confidence: 99%