Neuroligin fragments as blood-based biomarkers for early detection of Alzheimer’s disease
Milton Guilherme Forestieri Fernandes,
Maxime Pinard,
Esen Sokullu
et al.
Abstract:Biomarkers for early detection of Alzheimer's disease (AD) are essential for improving treatments. Fragments of the synaptic protein neuroligins (NLGNs) are released into the blood due to synaptic degeneration, which occurs in the early stages of AD. Using MS2-targeted mass spectrometry, we assessed the potential of NLGN fragments as blood-based biomarkers for amnestic mild cognitive impairment (aMCI), a prodromal stage of AD. We found higher blood levels of certain NLGN fragments in both aMCI and AD patients … Show more
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