Neuroleptic Malignant Syndrome in Children and Adolescents

Neuroleptic malignant syndrome in a 4-year-old girl associated with alimemazine

“…Throughout the world, Silva et al [11] found 77 described paediatric cases from 1966 to 1998 in Medline and from 1994 to 1998 in Psychinfo, with an average age of 15 years. Only a few patients under 6 years were mentioned.…”

Antipsychotic Drugs Rechallenge in Multi-antipsychotic Drug Induced Atypical Neuroleptic Malignant Syndrome: A Case of Cotard’s Syndrome

“…Incidence and mortality of NMS has declined in recent years owing to the awareness on the disorder. Estimated incidence is about 0.01-0.02% for patients treated with anti-psychotics, but it has not yet been clarified for children and adolescents (2,3).…”

Evaluation and Management of Children With Acute Mental Health or Behavioral Problems. Part II: Recognition of Clinically Challenging Mental Health Related Conditions Presenting With Medical or Uncertain Symptoms

“…50,71,72 With the increasing use of antipsychotic medications in the pediatric population, clinicians caring for children and adolescents may encounter this syndrome. 73 Given that NMS can be difficult to recognize and attenuated or incomplete presentations are possible, NMS is challenging to diagnose. 71,74 The incidence of NMS has been difficult to determine, with estimates ranging from 0.02% to 3%.…”